Listar BMB - Artículos por fecha de publicación
Mostrando ítems 21-40 de 168
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ReadqPCR and NormqPCR: R packages for the reading, quality checking and normalisation of RT-qPCR quantification cycle (Cq) data
(BMC, 2012-07)Background: Measuring gene transcription using real-time reverse transcription polymerase chain reaction (RT-qPCR) technology is a mainstay of molecular biology. Technologies now exist to measure the abundance of many ... -
Alteration of the Interconversion of Pyruvate and Malate in the Plastid or Cytosol of Ripening Tomato Fruit Invokes Diverse Consequences on Sugar But Similar Effects on Cellular Organic Acid, Metabolism, and Transitory Starch Accumulation.
Osorio-Algar, Sonia
; Vallarino, José G.; Szecowka, Marek; Ufaz, Shai; Tzin, Vered; Angelovici, Ruthie; Galili, Gad; Fernie, Alisdair R.[et al.] (Oxford Academic, 2012-12-18)
The aim of this work was to investigate the effect of decreased cytosolic phosphoenolpyruvate carboxykinase (PEPCK) and plastidic NADP-dependent malic enzyme (NADP-ME) on tomato (Solanum lycopersicum) ripening. Transgenic ... -
Autophagy mediates caloric restriction-induced lifespan extension in Arabidopsis.
Minina, Alyona; Sánchez-Vera, Victoria; Moschou, Panagiotis N.; Suárez-Marín, María Fernanda; Sundberg, Eva; Weih, Martin; Bozhkov, Peter V.[et al.] (Aging Cell/Blackwell publishing Ltd/Anatomical Society of Great Britain and Ireland, 2013-01-17)
Caloric restriction (CR) extends lifespan in various heterotrophic organisms ranging from yeasts to mammals, but whether a similar phenomenon occurs in plants remains unknown. Plants are autotrophs and use their photosynthetic ... -
Anti-angiogenic properties of carnosol and carnosic acid, two major dietary compounds from rosemary.
López-Jiménez, Auxiliadora; García-Caballero, Melissa; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María (Springer, 2013-02-01)
Antecedentes: El uso de las hojas de romero (Rosmarinus officinalis) y sus componentes como fuente de antioxidantes dietéticos y agentes aromatizantes está en continuo crecimiento. El carnosol y el ácido carnósico, dos ... -
The SUD1 Gene Encodes a Putative E3 Ubiquitin Ligase and Is a Positive Regulator of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Activity in Arabidopsis.
G. Doblas, Verónica; Amorim-Silva, Vitor; Posé-Padilla, David; Rosado, Abel; Esteban, Alicia; Arró, Montserrat; Azevedo, Herlânder; Bombarely, Aureliano; Borsani, Omar; Valpuesta-Fernández, Victoriano; Ferrer, Albert; Tavares, Rui M.; Botella-Mesa, Miguel Ángel[et al.] (American Society of Plant Biologists, 2013-02-12)
The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) enzyme catalyzes the major rate-limiting step of the mevalonic acid (MVA) pathway from which sterols and other isoprenoids are synthesized. In contrast with our extensive ... -
Toluquinol, a marine fungus metabolite, is a new angiosuppresor that interferes the Akt pathway.
García-Caballero, Melissa; Mari-Beffa, Manuel; Cañedo, Librada; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María (Elsevier, 2013-06-15)
El toluquinol, una metilhidroquinona producida por un hongo marino, fue seleccionado en el curso de una selección a ciegas de nuevos inhibidores potenciales de la angiogénesis. En el presente estudio proporcionamos la ... -
PainNetworks: A web-based resource for the visualisation of pain related genes in the context of their network associations.
(IASP/Wolters Kluwer, 2013-08-11)We now know of hundreds of genes that have some association with pain. Several genes have been shown to alter pain sensitivity in humans, and can be found in the OMIM database. The Pain Gene Database gives details of genes ... -
Ethylene signaling: simple ligand, complex regulation
(ELSEVIER, 2013-10)The hormone ethylene plays numerous roles in plant development. In the last few years the model of ethylene signaling has evolved from an initially largely linear route to a much more complex pathway with multiple feedback ... -
Ethylene is involved in strawberry fruit ripening in an organ-specific manner.
Merchante, Catharina; Valpuesta, Victoriano; Vallarino, José G.; Osorio-Algar, Sonia; Aragüez, Irene; Villareal, Natalia; Ariza, Maria T.; Martínez, Gustavo A.; Medina-Escobar, Nieves; Civello, Marcos P.; Fernie, Alisdair R.; Botella-Mesa, Miguel Ángel[et al.] (Oxford Academic, 2013-10-05)
The fruit of the strawberry F.ananassa has traditionally been classified as non-climacteric because its ripen- ing process is not governed by ethylene. However, previous studies have reported the timely endogenous ... -
Ethylene is involved in strawberry fruit ripening in an organ-specific manner
Merchante-Berg, Catharina; Vallarino Castro, José G.; Osorio-Algar, Sonia; Aragüez, Irene; Villarreal, Natalia; Ariza, María T.; Martínez, Gustavo A.; Medina-Escobar, Nieves; Civello, Marcos P.; Fernie, Alisdair R; Botella, Miguel A.; Valpuesta-Fernández, Victoriano[et al.] (Oxford University Press [University Publisher], Society for Experimental Biology [Society Publisher], 2013-11)
The fruit of the strawberry F ananassa has traditionally been classified as non-climacteric because its ripening process is not governed by ethylene. However, previous studies have reported the timely endogenous production ... -
Autophagy and metacaspase determine the mode of cell death in plants
Minina, Elena A; Filonova, Lada H; Fukada, Kazutake; Savenkov, Eugene I; Gogvadze, Vladimir; Clapham, David; Sánchez-Vera, Victoria; Suárez-Marín, María Fernanda; Zhivotovsky, Boris; Daniel, Geoffrey; Smertenko, Andrei; Bozhkov, Peter V[et al.] (Rockefeller University Press, 2013-12-16)
Although animals eliminate apoptotic cells using macrophages, plants use cell corpses throughout development and disassemble cells in a cell- autonomous manner by vacuolar cell death. During vacuolar cell death, lytic ... -
Both GLS silencing and GLS2 overexpression synergize with oxidative stress against proliferation of glioma cells.
Martín-Rufián, Mercedes; Nascimento-Gomes, Renata; Higuero, Ana; Crisma, Amanda R.; Campos-Sandoval, José A.; Gómez-García, María C.; Cardona, Carolina; Cheng, Tzuling; Lobo, Carolina; Segura-Checa, Juan Antonio; Alonso-Carrión, Francisco José; Szeliga, Monika; Albrecht, Jan; Curi, Rui; Márquez-Gómez, Javier; Colquhoun, Alison; DeBerardinis, Ralph J; Mates-Sánchez, José Manuel[et al.] (Springer Nature, 2014)
Mitochondrial glutaminase (GA) plays an essential role in cancer cell metabolism, contributing to biosynthesis, bioenergetics, and redox balance. Humans contain several GA isozymes encoded by the GLS and GLS2 genes, but ... -
Abiotic stresses differentially affect the expression of O-methyltransferase genes related to methoxypyrazine biosynthesis in seeded and parthenocarpic fruits of Vitis vinifera (L.)
(Elsevier, 2014-01-08)MPs (3-alkyl-2-methoxypyrazines) are grape-derived aroma compounds that are associated with detrimental herbaceous flavours in some wines. It is well known that several viticultural and environmental parameters can modulate ... -
The Marine Fungal Metabolite, AD0157, Inhibits Angiogenesis by Targeting the Akt Signaling Pathway
García-Caballero, Melissa; Cañedo, Librada; Fernández-Medarde, Antonio; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María (MDPI, 2014-01-16)
En el marco de un programa de selección de inhibidores de la angiogénesis de origen marino, se seleccionó AD0157, un metabolito fúngico de la pirrolidinediona, por sus propiedades angiosupresoras. AD0157 inhibió el crecimiento ... -
A development of chimeric VEGFR2 TK inhibitor based on two ligand conformers from PDB: 1Y6A complex--medicinal chemistry consequences of a TKs analysis
Lintnerová, Lucia; García-Caballero, Melissa; Fridrich, Gregáň; Melicherčík, Milan; Rodríguez-Quesada, Ana María; Dobiaš, Juraj; Lác, Ján; Sališová, Marta; Boháč, Andrej[et al.] (Elsevier, 2014-01-24)
El VEGFR2 es un importante mediador de la angiogénesis e influye en el destino de algunas células madre cancerosas. Aquí analizamos las 34 estructuras de VEGFR2 TK disponibles en la base de datos PDB. De ellas, un complejo ... -
A comparison of RNA-seq and exon arrays for whole genome transcription profiling of the L5 spinal nerve transection model of neuropathic pain in the rat
(SAGE Publications, 2014-01-28)The past decade has seen an abundance of transcriptional profiling studies of preclinical models of persistent pain, predominantly employing microarray technology. In this study we directly compare exon microarrays to ... -
Can a minimal replicating construct be identified as the embodiment of cancer?
Solé, Ricard V.; Valverde, Sergi; Rodríguez-Caso, Carlos Francisco; Sardanyés, Josep (Wiley, 2014-04)
Genomic instability is a hallmark of cancer. Cancer cells that exhibit abnormal chromosomes are characteristic of most advanced tumours, despite the potential threat represented by accumulated genetic damage. Carcinogenesis ... -
Can cell mortality determine division of labor in tissue organization?
Rodríguez-Caso, Carlos Francisco (Elsevier, 2014-06)
Tissue organization comes from the emergence of cell cooperation where cell homeostasis and function are per- formed as a trade-off of two excluding proliferative and differentiated cellular states. By introducing function ... -
A bottom-up characterization of transfer functions for synthetic biology designs: lessons from enzymology
Carbonell-Ballesteros, Max; Durán-Nebreda, Salva; Montañez, Raúl; Macía, Javier; Rodríguez-Caso, Carlos Francisco (Oxfrod University Press, 2014-12-16)
Within the field of synthetic biology, a rational design of genetic parts should include a causal understanding of their input-output responses-the so-called transfer function-and how to tune them. However, a commonly ... -
MiR-2 family regulates insect metamorphosis by controlling the juvenile hormone signaling pathway.
Fernández-Lozano, Jesús; Montañez, Raúl; Bellés, Xavier (National Academy of Sciences, 2015)
In 2009 we reported that depletion of Dicer-1, the enzyme that catalyzes the final step of miRNA biosynthesis, prevents metamorphosis in Blattella germanica. However, the precise regulatory roles of miRNAs in the process ...