Listar BMB - Artículos por tipo "info:eu-repo/semantics/article"
Mostrando ítems 21-40 de 168
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Antiangiogenic potential of an olive oil extract: insights from a proteomic study
Marrero Capitán, Ana Dácil; Cárdenas García, Casimiro; Castilla, Laura; Ortega Vidal, Juan; Rodríguez-Quesada, Ana María
; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel[et al.] (ACS, 2024)
Extra virgin olive oil (EVOO), a staple of the Mediterranean diet, is rich in phenolic compounds recognized for their potent bioactive effects, including anticancer and anti-inflammatory properties. However, its effects ... -
Antioxidant responses related to temozolomide resistance in glioblastoma
Campos-Sandoval, José Ángel; Gómez-García, María C.; Santos-Jiménez, Juan de los; Mates-Sánchez, José Manuel; Alonso-Carrión, Francisco José; Márquez-Gómez, Javier[et al.] (Elsevier, 2021)
Glioblastoma remains one of the most challenging and devastating cancers, with only a very small proportion of patients achieving 5-year survival. The current standard of care consists of surgery, followed by radiation ... -
Antioxidant, Immunomodulatory and Potential Anticancer Capacity of Polysaccharides (Glucans) from Euglena gracilis G.A. Klebs
Casas Arrojo, Virginia; Arrojo-Agudo, María Ángeles; Cárdenas García, Casimiro; Carrillo Fernández, Paloma; Pérez Manríquez, Claudia; Martínez-Manzanares, Eduardo; Abdala-Díaz, Roberto Teófilo[et al.] (IOAP-MDPI, 2022-11-10)
The present study was carried out to determine the bioactivity of polysaccharides extracted from Euglena gracilis (EgPs). These were characterized by FT-IR and GC-MS. Cytotoxicity analyses (MTT) were performed on healthy ... -
Arabidopsis Squalene Epoxidase 3 (SQE3) Complements SQE1 and Is Important for Embryo Development and Bulk Squalene Epoxidase Activity
Laranjeira, Sara; Amorim-Silva, Vitor; Esteban del Valle, Alicia; Arró, Montserrat; Ferrer, Albert; Tavares, Rui M.; Botella-Mesa, Miguel Ángel; Rosado, Abel; Azevedo, Herlânder[et al.] (ScienceDirect, 2015-07-06)
The existence of multigenic families in the mevalonate pathway suggests divergent functional roles for pathway components involved in the biosynthesis of plant sterols. Squalene epoxidases (SQEs) are key components of this ... -
Attenuation of cocaine-induced conditioned locomotion is associated with altered expression of hippocampal glutamate receptors in mice lacking LPA1 receptors.
Blanco-Calvo, Eduardo; Bilbao, Ainhoa; Luque-Rojas, María Jesús; Palomino, Ana; Bermúdez Silva, Francisco Javier; Suárez-Pérez, Juan; Santín-Núñez, Luis Javier; Estivill-Torrús, Guillermo; Gutiérrez-Pérez, Antonia; Campos-Sandoval, José A.; Márquez-Gómez, Javier; Rodriguez-de-Fonseca, Fernando[et al.] (Springer, 2012)
Lysophosphatidic acid is a phospholipid mediator that modulates neurodevelopment and neurogenesis in the hippocampus through its actions on LPA1 receptors. Emerging evidences support LPA1 as a mediator of learning and ... -
Autophagy and metacaspase determine the mode of cell death in plants
Minina, Elena A; Filonova, Lada H; Fukada, Kazutake; Savenkov, Eugene I; Gogvadze, Vladimir; Clapham, David; Sánchez-Vera, Victoria; Suárez-Marín, María Fernanda; Zhivotovsky, Boris; Daniel, Geoffrey; Smertenko, Andrei; Bozhkov, Peter V[et al.] (Rockefeller University Press, 2013-12-16)
Although animals eliminate apoptotic cells using macrophages, plants use cell corpses throughout development and disassemble cells in a cell- autonomous manner by vacuolar cell death. During vacuolar cell death, lytic ... -
Autophagy is required for gamete differentiation in the moss Physcomitrella patens.
(Autophagy / Landes Biosciences, 2017-09-25)Autophagy, a major catabolic process in eukaryotes, was initially related to cell tolerance to nutrient depletion. In plants autophagy has also been widely related to tolerance to biotic and abiotic stresses (through the ... -
Autophagy is required for strawberry fruit ripening
Sánchez-Sevilla, José F; Botella-Mesa, Miguel Ángel; Valpuesta-Fernández, Victoriano; Sánchez-Vera, Victoria (Frontiers Media SA, 2021-08-27)
Autophagy is a catabolic and recycling pathway that maintains cellular homeostasis under normal growth and stress conditions. Two major types of autophagy, microautophagy and macroautophagy, have been described in plants. ... -
Autophagy mediates caloric restriction-induced lifespan extension in Arabidopsis.
Minina, Alyona; Sánchez-Vera, Victoria; Moschou, Panagiotis N.; Suárez-Marín, María Fernanda; Sundberg, Eva; Weih, Martin; Bozhkov, Peter V.[et al.] (Aging Cell/Blackwell publishing Ltd/Anatomical Society of Great Britain and Ireland, 2013-01-17)
Caloric restriction (CR) extends lifespan in various heterotrophic organisms ranging from yeasts to mammals, but whether a similar phenomenon occurs in plants remains unknown. Plants are autotrophs and use their photosynthetic ... -
Biomarker potential of repetitive-element transcriptome in lung cancer
Claros-Díaz, Manuel Gonzalo; Arroyo, Macarena; Bautista-Moreno, Rocío; Larrosa-Jiménez, Rafael; Cobo, Manuel Ángel (PeerJ, 2019)
Since repetitive elements (REs) account for nearly 53% of the human genome, profiling its transcription after an oncogenic change might help in the search for new biomarkers. Lung cancer was selected as target since it is ... -
Both GLS silencing and GLS2 overexpression synergize with oxidative stress against proliferation of glioma cells.
Martín-Rufián, Mercedes; Nascimento-Gomes, Renata; Higuero, Ana; Crisma, Amanda R.; Campos-Sandoval, José A.; Gómez-García, María C.; Cardona, Carolina; Cheng, Tzuling; Lobo, Carolina; Segura-Checa, Juan Antonio; Alonso-Carrión, Francisco José; Szeliga, Monika; Albrecht, Jan; Curi, Rui; Márquez-Gómez, Javier; Colquhoun, Alison; DeBerardinis, Ralph J; Mates-Sánchez, José Manuel[et al.] (Springer Nature, 2014)
Mitochondrial glutaminase (GA) plays an essential role in cancer cell metabolism, contributing to biosynthesis, bioenergetics, and redox balance. Humans contain several GA isozymes encoded by the GLS and GLS2 genes, but ... -
Bringing Light to Science Undergraduate Students: A Successful Laboratory Experiment Illustrating the Principles and Applications of Bioluminescence
García-Ponce, Ángel Luis; Torres-Vargas, José Antonio; García-Caballero, Melissa; Medina-Torres, Miguel Ángel; Blanco-López, Ángel; Rodríguez-Quesada, Ana María[et al.] (ACS Publications, 2021)
Although many laboratory experiments are available to illustrate spectrophotometric or fluorometric methods, few of them introduce the use of luminometry to students. Bioluminescence, a subtype of chemiluminescence, ... -
Can a minimal replicating construct be identified as the embodiment of cancer?
Solé, Ricard V.; Valverde, Sergi; Rodríguez-Caso, Carlos Francisco; Sardanyés, Josep (Wiley, 2014-04)
Genomic instability is a hallmark of cancer. Cancer cells that exhibit abnormal chromosomes are characteristic of most advanced tumours, despite the potential threat represented by accumulated genetic damage. Carcinogenesis ... -
Can cell mortality determine division of labor in tissue organization?
Rodríguez-Caso, Carlos Francisco (Elsevier, 2014-06)
Tissue organization comes from the emergence of cell cooperation where cell homeostasis and function are per- formed as a trade-off of two excluding proliferative and differentiated cellular states. By introducing function ... -
Causes of B chromosome variant substitution in the grasshopper Eyprepocnemis plorans
Manrique-Poyato, María Inmaculada; Muñoz-Pajares, Antonio Jesús; Loreto, Vilma; López-León, María Dolores; Cabrero-Hurtado, Josefa; Martínez-Camacho, Juan Pedro[et al.] (Springer, 2006)
We have analysed B chromosome frequency for three consecutive years, B transmission rate at population and individual levels, clutch size, egg fertility and embryoYadult viability in a natural population of the ... -
Characterisation of non-coding genetic variation in histamine receptors using AnNCR-SNP.
Rojano, Elena; García-Ranea, Juan Antonio; Perkins, James Richard (Springer, 2016-06-06)
Almost 90 % of disease-associated genetic variants found using genome wide association studies (GWAS) are located in non-coding regions of the genome. Such variants can affect phenotype by altering important regulatory ... -
Characterization of the activity and the mechanism of action of a new toluquinol derivative with improved potential as an antiangiogenic drug.
Torres-Vargas, José Antonio; Cheng-Sánchez, Iván; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel; Sarabia-García, Francisco Ramón; García-Caballero, Melissa; Rodríguez-Quesada, Ana María[et al.] (Elsevier, 2022-09-30)
The inhibition of sustained angiogenesis is an attractive approach for the treatment of cancer, blindness and other angiogenesis-dependent diseases. Encouraged by our previous finding that toluquinol, a methyl hydroquinone ... -
Characterizing the involvement of FaMADS9 in the regulation of strawberry fruit receptacle development
Vallarino Castro, José G.; Merchante-Berg, Catharina; Sánchez-Sevilla, José F; De Luis Balaguer, María Angels; Pott, Delphine; Ariza Fernández, María Teresa; Casañal, Ana; Posé-Padilla, David; Vioque, Amalia; Amaya Saavedra, Iraida; Willmitzer, Lothar; Solano, Roberto; Sozzani, Rosangela; Fernie, Alisdair R; Botella-Mesa, Miguel Ángel; Giovannoni, James J.; Valpuesta-Fernández, Victoriano; Osorio-Algar, Sonia[et al.] (Wiley Online Library, 2019-09-18)
FaMADS9 is the strawberry (Fragaria x ananassa) gene that exhibits the highest homology to the tomato (Solanum lycopersicum) RIN gene. Transgenic lines were obtained in which FaMADS9 was silenced. The fruits of these lines ... -
Characterizing the involvement of FaMADS9 in the regulation of strawberry fruit receptacle development
Vallarino, JG; Merchante, C; Sanchez-Sevilla, JF; De Luis Balaguer, MA; Pott, DM; Ariza, MT; Casañal, A; Posé-Padilla, David; Vioque, A; Amaya, I; Willmitzer, L; Solano, R; Sozzani, R; Fernie, AR; Botella, MA; Giovannoni, JJ; Valpuesta, V; Osorio-Algar, Sonia[et al.] (2020)
FaMADS9 is the strawberry (Fragaria x ananassa) gene that exhibits the highest homology to the tomato (Solanum lycopersicum) RIN gene. Transgenic lines were obtained in which FaMADS9 was silenced. The fruits of these lines ... -
Cocaine modulates both glutaminase gene expression and glutaminase activity in the brain of cocaine-sensitized mice
Blanco-Calvo, Eduardo; Campos-Sandoval, José Ángel; Palomino, Ana; Luque-Rojas, María Jesús; Bilbao, Ainhoa; Suárez, Juan; Márquez-Gómez, Javier; Rodriguez-de-Fonseca, Fernando[et al.] (Springer, 2012)
Glutaminase is considered the main Glutamate (Glu) producing enzyme. Two isoforms, liver (LGA) and kidney (KGA) type glutaminases have been identified in neurons. The role of both enzymes in psychopharmacological responses ...