Listar BMB - Artículos por título
Mostrando ítems 160-179 de 193
-
Synthetic circuit designs for earth terraformation
(Springer Nature, 2015-07-18)Background: Mounting evidence indicates that our planet might experience runaway effects associated to rising temperatures and ecosystem overexploitation, leading to catastrophic shifts on short time scales. Remediation ... -
Synthetic collective intelligence.
(Elsevier, 2016)Intelligent systems have emerged in our biosphere in different contexts and achieving different levels of complexity. The requirement of communication in a social context has been in all cases a determinant. The human ... -
Targeting VEGFR-3/-2 signaling pathways with AD0157: a potential strategy against tumor-associated lymphangiogenesis and lymphatic metastases
(BMC, 2017-06-19)La metástasis linfática es una de las principales causas de muerte en pacientes con diferentes tipos de cáncer y es el principal factor pronóstico para la supervivencia de la enfermedad. La formación de nuevos vasos ... -
The antiangiogenic compound aeroplysinin-1 induces apoptosis in endothelial cells by activating the mitochondrial pathway.
(MDPI, 2012-09-18)La aeropolisinina-1 es un metabolito bromado extraído de la esponja marina Aplysina aerophoba que ha sido caracterizado previamente por nuestro grupo como un potente compuesto antiangiogénico in vitro e in vivo. En este ... -
The Arabidopsis TETRATRICOPEPTIDE THIOREDOXIN-LIKE 1 Gene Is Involved in Anisotropic Root Growth during Osmotic Stress Ad.aptation
(MDPI, 2021-02-07)Mutations in the Arabidopsis TETRATRICOPEPTIDE THIOREDOXIN-LIKE 1 (TTL1) gene cause reduced tolerance to osmotic stress evidenced by an arrest in root growth and root swelling, which makes it an interesting model to explore ... -
The immunomodulator dimethyl itaconate inhibits several key steps of angiogenesis in cultured endothelial cells
(MDPI, 2022)The dimethyl derivative of the immunomodulator itaconate has been previously shown to have anti-inflammatory, anti-oxidative, and immunomodulatory effects. In the present work, we evaluate the potential of dimethyl itaconate ... -
The Marine Fungal Metabolite, AD0157, Inhibits Angiogenesis by Targeting the Akt Signaling Pathway
(MDPI, 2014-01-16)En el marco de un programa de selección de inhibidores de la angiogénesis de origen marino, se seleccionó AD0157, un metabolito fúngico de la pirrolidinediona, por sus propiedades angiosupresoras. AD0157 inhibió el crecimiento ... -
The NAC transcription factor FaRIF controls fruit ripening in strawberry
(Oxford University Press, 2021-02-24)In contrast to climacteric fruits such as tomato, the knowledge on key regulatory genes controlling the ripening of straw- berry, a nonclimacteric fruit, is still limited. NAC transcription factors (TFs) mediate different ... -
The NAC transcription factor FaRIF controls fruit ripening in strawberry
(Oxford University Press, 2021-02-24)In contrast to climacteric fruits such as tomato, the knowledge on key regulatory genes controlling the ripening of straw- berry, a nonclimacteric fruit, is still limited. NAC transcription factors (TFs) mediate different ... -
The NAC transcription factor FaRIF controls fruit ripening in strawberry.
(Oxford University Press [University Publisher], American Society of Plant Biologists [Society Publisher], 2021-02-24)In contrast to climacteric fruits such as tomato, the knowledge on key regulatory genes controlling the ripening of strawberry, a nonclimacteric fruit, is still limited. NAC transcription factors (TFs) mediate different ... -
The noni anthraquinone damnacanthal is a multi-kinase inhibitor with potent anti-angiogenic effects
(Elsevier, 2017-01)The natural bioactive compound damnacanthal inhibits several tyrosine kinases. Herein, we show that -in fact- damancanthal is a multi kinase inhibitor. A docking and molecular dynamics simulation approach allows getting ... -
The Physcomitrium patens egg cell expresses several distinct epigenetic components and utilizes homologs of BONOBO genes for cell specification
(Wiley, 2022-02-17)Although land plant germ cells have received much attention, knowledge about their speci-fication is still limited. We thus identified transcripts enriched in egg cells of the bryophyte model species Physcomitrium patens, ... -
The role of alpha1-fetoprotein transcription factor/LRH-1 in bile acid biosynthesis: a known nuclear receptor actovator that can act as a suppressor of bile acid biosynthesis
(American Society for Biochemistry and Molecular Biology, 2004)Two key regulatory enzymes in the bile acid biosynthesis pathway are cholesterol 7alpha-hydroxylase/CYP7A1 (7alpha-hydroxylase) and sterol 12alpha-hydroxylase/CYP8B1 (12alpha-hydroxylase). It has been shown previously that ... -
The role of fatty acid β-oxidation in lymphangiogenesis.
(Nature, 2017-02-02)Los vasos linfáticos están revestidos por células endoteliales linfáticas (LEC) y son fundamentales para la salud. Sin embargo, aún no se ha dilucidado el papel del metabolismo en el desarrollo linfático. En este trabajo ... -
The role of GDP-L-galactose phosphorylase in the control of ascorbate biosynthesis
(Oxford University Press in behalf of American Society of Plant Biologists, 2021-01-25)The enzymes involved in l-ascorbate biosynthesis in photosynthetic organisms (the Smirnoff–Wheeler [SW] pathway) are well established. Here, we analyzed their subcellular localizations and potential physical interactions ... -
The Sponge-Derived Brominated Compound Aeroplysinin-1 Impairs the Endothelial Inflammatory Response through Inhibition of the NF-κB Pathway
(MDPI, 2022)Aeroplysinin-1 (Apl-1) is a brominated compound isolated from the marine sponge Aplysina aerophoba that exhibits pleiotropic bioactive effects, impairing cell growth in cancer cells, inhibiting angiogenesis in vitro and ... -
The SUD1 Gene Encodes a Putative E3 Ubiquitin Ligase and Is a Positive Regulator of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Activity in Arabidopsis.
(American Society of Plant Biologists, 2013-02-12)The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) enzyme catalyzes the major rate-limiting step of the mevalonic acid (MVA) pathway from which sterols and other isoprenoids are synthesized. In contrast with our extensive ... -
The synthetic molecule stauprimide impairs cell growth and migration in triple-negative breast cancer
(Elsevier, 2022-12-14)Stauprimide, a semi-synthetic derivative of staurosporine, is known mainly for its potent differentiation-enhancing properties in embryonic stem cells. Here, we studied the effects of stauprimide in cell growth and migration ... -
Therapeutic targeting of glutaminolysis as an essential strategy to combat cancer
(Elsevier, 2020-02)Metabolic reprogramming in cancer targets glutamine metabolism as a key mechanism to provide energy, biosynthetic precursors and redox requirements to allow the massive proliferation of tumor cells. Glutamine is also a ... -
Toluquinol, a marine fungus metabolite, is a new angiosuppresor that interferes the Akt pathway.
(Elsevier, 2013-06-15)El toluquinol, una metilhidroquinona producida por un hongo marino, fue seleccionado en el curso de una selección a ciegas de nuevos inhibidores potenciales de la angiogénesis. En el presente estudio proporcionamos la ...