Listar BMB - Artículos por título
Mostrando ítems 94-113 de 168
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Mammalian Glutaminase Gls2 Gene Encodes Two Functional Alternative Transcripts by a Surrogate Promoter Usage Mechanism.
(PLOS, 2012-06-05)Glutaminase is expressed in most mammalian tissues and cancer cells, but the regulation of its expression is poorly understood. An essential step to accomplish this goal is the characterization of its species- and cell-specific ... -
MangoBase: a genomics portal and gene expression atlas for Mangifera indica
(MDPI, 2023-03-10)Mango (Mangifera indica L.) (2n = 40) is a member of the Anacardiaceae family, which was domesticated at least 4000 years ago in Asia. Mangoes are delicious fruits with great nutritional value. They are one of the major ... -
Mathematical modeling of cancer metabolism
(2018-10-19)Systemic approaches are needed and useful for the study of the very complex issue of cancer. Modeling has a central position in these systemic approaches. Metabolic reprogramming is nowadays acknowledged as an essential ... -
Mathematical Modeling of Polyamine Metabolism in Mammals.
(Elsevier, 2006)Polyamines are considered as essential compounds in living cells, since they are involved in cell proliferation, transcription, and translation processes. Furthermore, polyamine homeostasis is necessary to cell survival, ... -
Metabolic Adjustments following Glutaminase Inhibition by CB-839 in Glioblastoma Cell Lines
(IOAP-MDPI, 2023-01-15)Glioblastoma multiforme is the most common primary brain tumor. Unfortunately, it is also one of the cancer types that has the worst morbidity and mortality ratios, so new targets and treatments need to be found. The ... -
Metabolic Reprogramming in Tumor Endothelial Cells.
(MDPI, 2022-09-21)The dynamic crosstalk between the different components of the tumor microenvironment is critical to determine cancer progression, metastatic dissemination, tumor immunity, and therapeutic responses. Angiogenesis is critical ... -
Metabolic Reprogramming is a Hallmark of Metabolism Itself
(2020-09-23)The reprogramming of metabolism has been identified as one of the hallmarks of cancer. It is becoming more and more frequent to connect other diseases with metabolic reprogramming. This article aims to argue that metabolic ... -
Metabolism within the tumor microenvironment and its implication on cancer progression: an ongoing therapeutic target
(2018-10-19)Since reprogramming energy metabolism is considered a new hallmark of cancer, tumor metabolism is again in the spotlight of cancer research. Many studies have been carried out and many possible therapies have been developed ... -
MiR-2 family regulates insect metamorphosis by controlling the juvenile hormone signaling pathway.
(National Academy of Sciences, 2015)In 2009 we reported that depletion of Dicer-1, the enzyme that catalyzes the final step of miRNA biosynthesis, prevents metamorphosis in Blattella germanica. However, the precise regulatory roles of miRNAs in the process ... -
Modeling pre-metastatic lymphvascular niche in the mouse ear sponge assay
(2017-01-27)La linfangiogénesis. o formación de nuevos vasos linfáticos, ocurre en tumores primarios y en ganglios linfáticos de drenaje que conducen a la formación de nichos premetastásicos. Los modelos in vivo confiables se están ... -
Modification of plant hormone levels and signaling as a tool in plant biotechnology.
(Wiley, 2009-09-23)Plant hormones are signal molecules, present in trace quantities, that act as major regulators of plant growth and development. They are involved in a wide range of processes such as elongation, flowering, root formation ... -
Modulating Vascular Lymphatic Growth in Disease: Current and Potential Pharmacological Approaches for Prevention and Treatment
(Frontiers Media, 2022-04-25)The lymphatic system is part of the circulatory system and it is indispensable for life. In physiological conditions, the main functions assigned to the lymphatic system are the maintenance of the interstitial fluid ... -
Molecular Characterization of ZosmaNRT2, the Putative Sodium Dependent High-Affinity Nitrate Transporter of Zostera marina L.
(MDPI, 2019-07-26)One of the most important adaptations of seagrasses during sea colonization was the capacity to grow at the low micromolar nitrate concentrations present in the sea. In contrast to terrestrial plants that use H+ symporters ... -
MS1/MMD1 homologs in the moss P. patens are required for male and female gametogenesis.
(New Phytologist / Wiley, 2022-07-01)The Arabidopsis Plant HomeoDomain (PHD) proteins AtMS1 and AtMMD1 provide chromatin-mediated transcriptional regulation essential for tapetum-dependent pollen forma-tion. This pollen-based male gametogenesis is a derived ... -
Multi‐gene metabolic engineering of tomato plants results in increased fruit yield up to 23%.
(Springer Nature, 2020-10-14)The capacity to assimilate carbon and nitrogen, to transport the resultant sugars and amino acids to sink tissues, and to convert the incoming sugars and amino acids into storage compounds in the sink tissues, are key ... -
Network-Based Methods for Approaching Human Pathologies from a Phenotypic Point of View
(IOAP-MPDI, 2022-06-17)Network and systemic approaches to studying human pathologies are helping us to gain insight into the molecular mechanisms of and potential therapeutic interventions for human diseases, especially for complex diseases where ... -
Nitric oxide-dependent regulation of sweet pepper fruit ripening
(Journal of Experimental Botany, 2019)Ripening is a complex physiological process that involves changes in reactive nitrogen and oxygen species that govern the shelf-life and quality of fruits. Nitric oxide (NO)-dependent changes in the sweet pepper fruit ... -
Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity
(ELSEVIER, 2021-11)The tropical plant Annona muricata has been widely used for traditional ethnobotanic and pharmacologic applications. Extracts from different parts of this plant have been shown to have a wide range of biological activities. ... -
Novel application assigned to toluquinol: inhibition of lymphangiogenesis by interfering with VEGF-C/VEGFR-3 signalling pathway
(Wiley, 2016)BACKGROUND AND PURPOSE Lymphangiogenesis is an important biological process associated with the pathogenesis of several diseases, including metastatic dissemination, graft rejection, lymphoedema and other inflammatory ... -
Novel dimensionality reduction method, Taelcore, enhances lung transplantation risk prediction
(Elsevier, 2024-01-04)In this work, we present a new approach to predict the risk of acute cellular rejection (ACR) after lung transplantation by using machine learning algorithms, such as Multilayer Perceptron (MLP) or Autoencoder (AE), and ...