Listar BMB - Artículos por título
Mostrando ítems 91-110 de 167
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KinFams: De-Novo Classification of Protein Kinases Using CATH Functional Units
Adeyelu, Tolulope; Bordin, Nicola; Waman, Vaishali P.; Sadlej, Marta; Sillitoe, Ian; Moya-García, Aurelio Ángel
; Orengo, Christine A.[et al.] (IOAP-MDPI, 2023-02-02)
Protein kinases are important targets for treating human disorders, and they are the second most targeted families after G-protein coupled receptors. Several resources provide classification of kinases into evolutionary ... -
Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression of lymphatic genes and lymphangiogenesis.
(SpringerNature, 2022-05-19)Autophagy has vasculoprotective roles, but whether and how it regulates lymphatic endothelial cells (LEC) homeostasis and lymphangiogenesis is unknown. Here, we show that genetic deficiency of autophagy in LEC impairs ... -
Lysophosphatidic Acid and Glutamatergic Transmission.
Roza, Carolina; Campos-Sandoval, José Ángel; Gómez García, María del Carmen; Peñalver Alonso, Ana; Márquez-Gómez, Javier (Frontiers, 2019-05-28)
Signaling through bioactive lipids regulates nervous system development and functions. Lysophosphatidic acid (LPA), a membrane-derived lipid mediator particularly enriched in brain, is able to induce many responses in ... -
Mammalian Glutaminase Gls2 Gene Encodes Two Functional Alternative Transcripts by a Surrogate Promoter Usage Mechanism.
Martín-Rufián, Mercedes; Tosina, Marta; Campos-Sandoval, José Ángel; Manzanares, Elisa; Lobo, Carolina; Segura-Checa, Juan Antonio; Alonso-Carrión, Francisco José; Mates-Sánchez, José Manuel; Márquez-Gómez, Javier[et al.] (PLOS, 2012-06-05)
Glutaminase is expressed in most mammalian tissues and cancer cells, but the regulation of its expression is poorly understood. An essential step to accomplish this goal is the characterization of its species- and cell-specific ... -
MangoBase: a genomics portal and gene expression atlas for Mangifera indica
(MDPI, 2023-03-10)Mango (Mangifera indica L.) (2n = 40) is a member of the Anacardiaceae family, which was domesticated at least 4000 years ago in Asia. Mangoes are delicious fruits with great nutritional value. They are one of the major ... -
Mathematical modeling of cancer metabolism
Medina-Torres, Miguel Ángel (2018-10-19)
Systemic approaches are needed and useful for the study of the very complex issue of cancer. Modeling has a central position in these systemic approaches. Metabolic reprogramming is nowadays acknowledged as an essential ... -
Mathematical Modeling of Polyamine Metabolism in Mammals.
Rodríguez-Caso, Carlos Francisco; Montañez, Raúl; Cascante, Marta; Sánchez-Jiménez, Francisca María; Medina-Torres, Miguel Ángel (Elsevier, 2006)
Polyamines are considered as essential compounds in living cells, since they are involved in cell proliferation, transcription, and translation processes. Furthermore, polyamine homeostasis is necessary to cell survival, ... -
Metabolic Adjustments following Glutaminase Inhibition by CB-839 in Glioblastoma Cell Lines
De los Santos-Jiménez, Juan; Rosales, Tracy; Ko, Bookyung; Campos-Sandoval, José Ángel; Alonso-Carrión, Francisco José; Márquez-Gómez, Javier; DeBerardinis, Ralph J; Mates-Sánchez, José Manuel[et al.] (IOAP-MDPI, 2023-01-15)
Glioblastoma multiforme is the most common primary brain tumor. Unfortunately, it is also one of the cancer types that has the worst morbidity and mortality ratios, so new targets and treatments need to be found. The ... -
Metabolic Reprogramming in Tumor Endothelial Cells.
(MDPI, 2022-09-21)The dynamic crosstalk between the different components of the tumor microenvironment is critical to determine cancer progression, metastatic dissemination, tumor immunity, and therapeutic responses. Angiogenesis is critical ... -
Metabolic Reprogramming is a Hallmark of Metabolism Itself
Medina-Torres, Miguel Ángel (2020-09-23)
The reprogramming of metabolism has been identified as one of the hallmarks of cancer. It is becoming more and more frequent to connect other diseases with metabolic reprogramming. This article aims to argue that metabolic ... -
Metabolism within the tumor microenvironment and its implication on cancer progression: an ongoing therapeutic target
Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel; Ocaña Farfán, María del Carmen; Rodríguez-Quesada, Ana María (2018-10-19)
Since reprogramming energy metabolism is considered a new hallmark of cancer, tumor metabolism is again in the spotlight of cancer research. Many studies have been carried out and many possible therapies have been developed ... -
MiR-2 family regulates insect metamorphosis by controlling the juvenile hormone signaling pathway.
Fernández-Lozano, Jesús; Montañez, Raúl; Bellés, Xavier (National Academy of Sciences, 2015)
In 2009 we reported that depletion of Dicer-1, the enzyme that catalyzes the final step of miRNA biosynthesis, prevents metamorphosis in Blattella germanica. However, the precise regulatory roles of miRNAs in the process ... -
Modeling pre-metastatic lymphvascular niche in the mouse ear sponge assay
(2017-01-27)La linfangiogénesis. o formación de nuevos vasos linfáticos, ocurre en tumores primarios y en ganglios linfáticos de drenaje que conducen a la formación de nichos premetastásicos. Los modelos in vivo confiables se están ... -
Modification of plant hormone levels and signaling as a tool in plant biotechnology.
Csukasi, Fabiana; Merchante-Berg, Catharina; Valpuesta-Fernández, Victoriano (Wiley, 2009-09-23)
Plant hormones are signal molecules, present in trace quantities, that act as major regulators of plant growth and development. They are involved in a wide range of processes such as elongation, flowering, root formation ... -
Modulating Vascular Lymphatic Growth in Disease: Current and Potential Pharmacological Approaches for Prevention and Treatment
(Frontiers Media, 2022-04-25)The lymphatic system is part of the circulatory system and it is indispensable for life. In physiological conditions, the main functions assigned to the lymphatic system are the maintenance of the interstitial fluid ... -
Molecular Characterization of ZosmaNRT2, the Putative Sodium Dependent High-Affinity Nitrate Transporter of Zostera marina L.
Rubio-Valverde, Lourdes; Días-García, Jordi; Amorim-Silva, Vitor; Macho, Alberto P.; Botella-Mesa, Miguel Ángel; Fernández-García, José Antonio[et al.] (MDPI, 2019-07-26)
One of the most important adaptations of seagrasses during sea colonization was the capacity to grow at the low micromolar nitrate concentrations present in the sea. In contrast to terrestrial plants that use H+ symporters ... -
MS1/MMD1 homologs in the moss P. patens are required for male and female gametogenesis.
(New Phytologist / Wiley, 2022-07-01)The Arabidopsis Plant HomeoDomain (PHD) proteins AtMS1 and AtMMD1 provide chromatin-mediated transcriptional regulation essential for tapetum-dependent pollen forma-tion. This pollen-based male gametogenesis is a derived ... -
Multi‐gene metabolic engineering of tomato plants results in increased fruit yield up to 23%.
(Springer Nature, 2020-10-14)The capacity to assimilate carbon and nitrogen, to transport the resultant sugars and amino acids to sink tissues, and to convert the incoming sugars and amino acids into storage compounds in the sink tissues, are key ... -
Network-Based Methods for Approaching Human Pathologies from a Phenotypic Point of View
(IOAP-MPDI, 2022-06-17)Network and systemic approaches to studying human pathologies are helping us to gain insight into the molecular mechanisms of and potential therapeutic interventions for human diseases, especially for complex diseases where ... -
Nitric oxide-dependent regulation of sweet pepper fruit ripening
Claros-Díaz, Manuel Gonzalo; González-Gordo, Salvador; Bautista-Moreno, Rocío; Cañas, Amanda; Palma, José M.; Corpas, Francisco J.[et al.] (Journal of Experimental Botany, 2019)
Ripening is a complex physiological process that involves changes in reactive nitrogen and oxygen species that govern the shelf-life and quality of fruits. Nitric oxide (NO)-dependent changes in the sweet pepper fruit ...