Listar BMB - Artículos por título
Mostrando ítems 80-99 de 193
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Gene expression atlas of fruit ripening and transcriptome assembly from RNA-seq data in octoploid strawberry (Fragaria × ananassa)
(Springer Nature, 2017-10-23)RNA-seq has been used to perform global expression analysis of the achene and the receptacle at four stages of fruit ripening, and of the roots and leaves of strawberry (Fragaria × ananassa). About 967 million reads and ... -
Gene-specific translation regulation mediated by the hormone-signaling molecule EIN2
(ELSEVIER, 2015-10-22)The central role of translation in modulating gene activity has long been recognized, yet the systematic exploration of quantitative changes in translation at a genome-wide scale in response to a specific stimulus has only ... -
Gene3D: a domain-based resource for comparative genomics, functional annotation and protein network analysis
(Oxford University Press, 2012-01)Gene3D http://gene3d.biochem.ucl.ac.uk is a comprehensive database of protein domain assignments for sequences from the major sequence databases. Domains are directly mapped from structures in the CATH database or predicted ... -
Generation and analysis of ESTs from strawberry (Fragaria xananassa) fruits and evaluation of their utility in genetic and molecular studies
(BMC, 2010-09-17)Cultivated strawberry is a octoploid species whose fruit is highly appreciated due to its organoleptic properties and health benefits. However, information about the role played by different hormones on these processes ... -
Genetic and genome-wide transcriptomic analyses identify co- regulation of oxidative response and hormone transcript abundance with vitamin C content in tomato fruit.
(BioMed Central, 2012-05-14)L-ascorbic acid (AsA; vitamin C) is essential for all living plants where it functions as the main hydrosoluble antioxidant. It has diverse roles in the regulation of plant cell growth and expansion, photosynthesis, and ... -
Genetic architecture of nonadditive inheritance in Arabidopsis thaliana hybrids.
(PNAS, 2016-11-01)The ubiquity of nonparental hybrid phenotypes, such as hybrid vigor and hybrid inferiority, has interested biologists for over a century and is of considerable agricultural importance. Although examples of both phenomena ... -
Genetic diversity of strawberry germplasm using metabolomic biomarkers.
(Springer Nature, 2018-09-26)High-throughput metabolomics technologies can provide the quantification of metabolites levels across various biological processes in different tissues, organs and species, allowing the identification of genes underpinning ... -
Genome Editing as a Tool for Fruit Ripening Manipulation
(Frontiers, 2018-09-25)Over the last few years, a series of tools for genome editing have been developed, allowing the introduction of precise changes into plant genomes. These have included Zinc-finger nucleases (ZFNs), transcription activator-like ... -
GLS and GLS2 Glutaminase Isoenzymes in the Antioxidant System of Cancer Cells.
(MDPI, 2024-06-20)A pathway frequently altered in cancer is glutaminolysis, whereby glutaminase (GA) catalyzes the main step as follows: the deamidation of glutamine to form glutamate and ammonium. There are two types of GA isozymes, named ... -
Glutaminase and MMP-9 Downregulation in Cortex and Hippocampus of LPA1 Receptor Null Mice Correlate with Altered Dendritic Spine Plasticity
(Frontiers, 2017-09-05)Lysophosphatidic acid (LPA) is an extracellular lipid mediator that regulates nervous system development and functions acting through G protein-coupled receptors (GPCRs). Here we explore the crosstalk between LPA1 receptor ... -
Glutaminase isoenzymes in the metabolic 1 therapy of cancer
(Elsevier, 2018-07)Altered cellular metabolism is a hallmark of cancer. Cancer cells express isoforms of metabolic enzymes that may constitute therapeutic targets. Glutaminase controls glutamine metabolism and their expression correlate with ... -
Glutaminase isoforms expression switches microRNA levels and oxidative status in glioblastoma cells.
(BMC, 2021-02-20)Glutaminase isoenzymes GLS and GLS2 play apparently opposing roles in cancer: GLS acts as an oncoprotein, while GLS2 (GAB isoform) has context specific tumour suppressive activity. Some microRNAs (miRNAs) have been implicated ... -
Glutaminase-2 Expression Induces Metabolic Changes and Regulates Pyruvate Dehydrogenase Activity in Glioblastoma Cells
(MDPI, 2025-01-06)Glutaminase controls the first step in glutaminolysis, impacting bioenergetics, biosynthesis and oxidative stress. Two isoenzymes exist in humans, GLS and GLS2. GLS is considered prooncogenic and overexpressed in many ... -
Glutaminases regulate glutathione and oxidative stress in cancer.
(Springer Nature, 2020)Targeted therapies against cancer have improved both survival and quality of life of patients. However, metabolic rewiring evokes cellular mechanisms that reduce therapeutic mightiness. Resistant cells generate more ... -
High Levels of Variation Within Gene Sequences of Olea europaea L.
(Frontiers Media, 2019-01-08)Gene sequence variation in cultivated olive (Olea europaea L. subsp. europaea var. europaea), the most important oil tree crop of the Mediterranean basin, has been poorly evaluated up to now. A deep sequence analysis of ... -
Hydroxytyrosol targets extracellular matrix remodeling by endothelial cells and inhibits both ex vivo and in vivo angiogenesis
(Elsevier, 2017-04)The health benefits of olive oil are attributed to their bioactive compounds, such as hydroxytyrosol. Previously, we demonstrated that hydroxytyrosol inhibits angiogenesis in vitro. The present study aimed to: i) get further ... -
Identification of key molecular biomarkers involved in reactive and neurodegenerative processes present in inherited congenital hydrocephalus
(BMC, 2021)Periventricular extracellular oedema, myelin damage, inflammation, and glial reactions are common neuropathological events that occur in the brain in congenital hydrocephalus. The periventricular white matter is the most ... -
Identification of quantitative trait loci and candidate genes for primary metabolite content in strawberry fruit
(2019)Improvement of nutritional and organoleptic quality of fruits is a key goal in current strawberry breeding programs. The ratio of sugars to acids is a determinant factor contributing to fruit liking, although different ... -
Improved germination under osmotic stress of tobacco plantsoverexpressing a cell wall peroxidase
(FEBS Letter, 1999-05-01)The cell wall is a fundamental component in theresponse of plants to environmental changes. To directly assessthe role of the cell wall we have increased the expression andactivity of a cell wall associated peroxidase ... -
Inhibition of Endothelial Inflammatory Response by HT-C6, a Hydroxytyrosol Alkyl Ether Derivative.
(MDPI, 2023-07-28)Hydroxytyrosol (HT) is a bioactive phenolic compound naturally present in olives and extra virgin olive oil (EVOO) which is described as an antioxidant, antitumoral and antiangiogenic molecule. Previous studies of ...