BMB - Artículos
Envíos recientes
-
Regulation of L-ascorbic acid content in Strawberry fruits
Cruz-Rus, Eduardo; Amaya, Iraida; Sánchez Sevilla, José; Botella, Miguel Angel; Valpuesta-Fernández, Victoriano
(Oxford Academy, 2011-05-11)
Plants have several L-ascorbic acid (AsA) biosynthetic pathways, but the contribution of each one to the synthesis of AsA varyies between different species, organs, and developmental stages. Strawberry (Fragaria×ananassa) ... -
Vitamin C content in fruits: Biosynthesis and regulation
Fenech-Torres, Mario; Amaya, Iraida; Valpuesta-Fernández, Victoriano; Botella, Miguel Angel (Frontiers, 2019-01-24)
Throughout evolution, a number of animals including humans have lost the ability to synthesize ascorbic acid (ascorbate, vitamin C), an essential molecule in the physiology of animals and plants. In addition to its main ... -
Glutaminase isoenzymes in the metabolic 1 therapy of cancer
Mates-Sánchez, José Manuel; Campos-Sandoval, José Ángel; Márquez-Gómez, Javier (Elsevier, 2018-07)
Altered cellular metabolism is a hallmark of cancer. Cancer cells express isoforms of metabolic enzymes that may constitute therapeutic targets. Glutaminase controls glutamine metabolism and their expression correlate with ... -
Fruit yield and quality of strawberry plants transformed with a fruit specific strawberry pectate lyase gene.
Youssef, Sabry M.; Jiménez-Bermúdez, Silvia; Bellido, María Luz; Martín-Pizarro, Carmen; Barcelo-Muñoz, Marta; Abdal-Aziz, Samia; Caballero, José Luis; López Aranda, José Manuel; Pliego-Alfaro, Fernando; Muñoz, Juan; Quesada-Felice, Miguel Ángel; Mercado, José A.[et al.] (Elsevier, 2009-01-06)
Two transgenic strawberry lines (Pel 1 and Pel 3) containing the open reading frame of a fruit specific strawberry pectate lyase gene (FaplC) under the control of the CaMV35S promoter have been obtained to evaluate the ... -
Diversity Arrays Technology (DArT) marker platforms for diversity analysis and linkage mapping in a complex crop, the octoploid cultivated strawberry (Fragaria × ananassa)
Sánchez-Sevilla, José Federico; Hovath, Aniko; Botella-Mesa, Miguel Ángel; Gaston, Amèlia; Folta, Kevin; Kilian, Andrzej; Denoyes, Beatrice; Amaya, Iraida[et al.] (PLOS One, 2015-12-16)
Cultivated strawberry (Fragaria × ananassa) is a genetically complex allo-octoploid crop with 28 pairs of chromosomes (2n = 8x = 56) for which a genome sequence is not yet available. The diploid Fragaria vesca is considered ... -
EST-derived polymorphic microsatellites from cultivated strawberry (Fragaria × ananassa) are useful for diversity studies and varietal identification among Fragaria species
Gil-Ariza, David Jesús; Amaya, Iraida; Botella-Mesa, Miguel Ángel; Muñoz-Blanco, Juan; Caballero, José Luis; López Aranda, José Manuel; Valpuesta-Fernández, Victoriano; Sánchez-Sevilla, José F.[et al.] (Wiley, 2006-10-01)
Microsatellite or simple sequence repeat markers derived from expressed sequence tags (ESTs) provide genetic markers within potentially functional genes, which could be very useful for breeding programs. To date, the ... -
Fenretinide derivatives act as disrupters of serum Retinol Binding Protein (sRBP) interactions with Transthyretin (TTR) and the sRBP Receptor
Campos-Sandoval, José Ángel; Redondo, Clara; Kinsella, Gemma; Akos, Pal; Geraint, Jones; Eyre, Gwen; Hirst, Simon; Findlay, John[et al.] (ACS Publications, 2011-05)
Serum retinol binding protein (sRBP) is released from the liver as a complex with transthyretin (TTR), a process under the control of dietary retinol. Elevated levels of sRBP may be involved in reducing cellular responses ... -
Improved germination under osmotic stress of tobacco plantsoverexpressing a cell wall peroxidase
Amaya, Iraida; Botella-Mesa, Miguel Ángel; de la Calle, Mercedes; Medina, María; Heredia-Bayona, Antonio; Bress, Ray; Hasegawa, Paul; Quesada-Felice, Miguel Ángel; Valpuesta-Fernández, Victoriano[et al.] (FEBS Letter, 1999-05-01)
The cell wall is a fundamental component in theresponse of plants to environmental changes. To directly assessthe role of the cell wall we have increased the expression andactivity of a cell wall associated peroxidase ... -
The antiangiogenic compound aeroplysinin-1 induces apoptosis in endothelial cells by activating the mitochondrial pathway.
Martínez-Póveda, Beatriz Amparo; Rodríguez-Nieto, Salvador; García-Caballero, Melissa; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María (MDPI, 2012-09-18)
La aeropolisinina-1 es un metabolito bromado extraído de la esponja marina Aplysina aerophoba que ha sido caracterizado previamente por nuestro grupo como un potente compuesto antiangiogénico in vitro e in vivo. En este ... -
Genetic architecture of nonadditive inheritance in Arabidopsis thaliana hybrids.
(PNAS, 2016-11-01)The ubiquity of nonparental hybrid phenotypes, such as hybrid vigor and hybrid inferiority, has interested biologists for over a century and is of considerable agricultural importance. Although examples of both phenomena ... -
Metabolic reconfiguration of strawberry physiology in response to postharvest practices
Pott, Delphine; De Abreu e Lima, Francisco; Soria, Carmen; Willmitzer, Lothar; Fernie, Alisdair R; Nikoloski, Zoran; Osorio-Algar, Sonia; Vallarino, Jose G[et al.] (2020)
The strawberry fruit is perishable due to its high water content and soft texture, yet exhibits pleasant organo- leptic and nutritional profile. Here we conducted a metabolomics-driven analysis followed by linear modelling ... -
Metabolic Reprogramming of Cancer by Chemicals that Target Glutaminase Isoenzymes.
Mates-Sánchez, José Manuel; Campos-Sandoval, José Ángel; De los Santos-Jiménez, Juan; Segura-Checa, Juan Antonio; Alonso-Carrión, Francisco José; Márquez-Gómez, Javier[et al.] (BenthamScience, 2020)
Background: Metabolic reprogramming of tumours is a hallmark of cancer. Among the changes in the metabolic network of cancer cells, glutaminolysis is a key reaction altered in neoplasms. Glutaminase proteins control the ... -
Glutaminases regulate glutathione and oxidative stress in cancer.
Mates-Sánchez, José Manuel; Campos-Sandoval, José Ángel; De los Santos-Jiménez, Juan; Márquez-Gómez, Javier (Springer Nature, 2020)
Targeted therapies against cancer have improved both survival and quality of life of patients. However, metabolic rewiring evokes cellular mechanisms that reduce therapeutic mightiness. Resistant cells generate more ... -
Dysregulation of glutaminase and glutamine synthetase in cancer.
Mates-Sánchez, José Manuel; Campos-Sandoval, José Ángel; De los Santos-Jiménez, Juan; Márquez-Gómez, Javier (Elsevier, 2019)
Besides fast glucose catabolism, many types of cancers are characterized by elevated glutamine consumption. Medical oncology pursuits to block specific pathways, mainly glycolysis and glutaminolysis, in tumor cells to ... -
Small RNAs control sodium channel expression, nociceptor excitability, and pain thresholds
(Society for Neuroscience, 2010-08-11)To examine the role of small RNAs in peripheral pain pathways, we deleted the enzyme Dicer in mouse postmitotic damage-sensing neurons. We used a Nav1.8-Cre mouse to target those nociceptors important for inflammatory pain. ... -
The role of alpha1-fetoprotein transcription factor/LRH-1 in bile acid biosynthesis: a known nuclear receptor actovator that can act as a suppressor of bile acid biosynthesis
Del Castillo-Olivares, Antonio; Campos-Sandoval, José Ángel; Pandak, William M.; Gil, Gregorio (American Society for Biochemistry and Molecular Biology, 2004)
Two key regulatory enzymes in the bile acid biosynthesis pathway are cholesterol 7alpha-hydroxylase/CYP7A1 (7alpha-hydroxylase) and sterol 12alpha-hydroxylase/CYP8B1 (12alpha-hydroxylase). It has been shown previously that ... -
PGC-1 alpha activates CYP7A1 and bile acid biosynthesis
Shin, Dong-Ju; Campos-Sandoval, José Ángel; Gil, Gregorio; Osborne, Timothy F. (American Society for Biochemistry and Molecular Biology, 2003)
Cholesterol 7-alpha-hydroxylase (CYP7A1) is the key enzyme that commits cholesterol to the neutral bile acid biosynthesis pathway and is highly regulated. In the current studies, we have uncovered a role for the transcriptional ... -
The immunomodulator dimethyl itaconate inhibits several key steps of angiogenesis in cultured endothelial cells
Vidal-Valenzuela, Isabel; Fernández-Florido, Elena; Marrero-Capitán, Ana Dácil; Castilla-Ruiz, Laura; Rodríguez-Quesada, Ana María; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel[et al.] (MDPI, 2022)
The dimethyl derivative of the immunomodulator itaconate has been previously shown to have anti-inflammatory, anti-oxidative, and immunomodulatory effects. In the present work, we evaluate the potential of dimethyl itaconate ... -
Glutaminase-2 Expression Induces Metabolic Changes and Regulates Pyruvate Dehydrogenase Activity in Glioblastoma Cells
De los Santos-Jiménez, Juan; Campos-Sandoval, José Ángel; Rosales, Tracy; Ko, Bookyung; Alonso, Francisco J.; Márquez-Gómez, Javier; DeBerardinis, Ralph J; Mates-Sánchez, José Manuel[et al.] (MDPI, 2025-01-06)
Glutaminase controls the first step in glutaminolysis, impacting bioenergetics, biosynthesis and oxidative stress. Two isoenzymes exist in humans, GLS and GLS2. GLS is considered prooncogenic and overexpressed in many ... -
Axonal neuregulin 1 is a rate limiting but not essential factor for nerve remyelination
(Oxford University Press, 2013-07)Neuregulin 1 acts as an axonal signal that regulates multiple aspects of Schwann cell development including the survival and migration of Schwann cell precursors, the ensheathment of axons and subsequent elaboration of the ...