Biología Molecular y Bioquímica - (BMB): Envíos recientes
Mostrando ítems 1-20 de 535
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The role of fatty acid β-oxidation in lymphangiogenesis.
(Nature, 2017-02-02)Los vasos linfáticos están revestidos por células endoteliales linfáticas (LEC) y son fundamentales para la salud. Sin embargo, aún no se ha dilucidado el papel del metabolismo en el desarrollo linfático. En este trabajo ... -
Anti-angiogenic properties of carnosol and carnosic acid, two major dietary compounds from rosemary.
López-Jiménez, Auxiliadora; García-Caballero, Melissa; Medina-Torres, Miguel Ángel
; Rodríguez-Quesada, Ana María (Springer, 2013-02-01)
Antecedentes: El uso de las hojas de romero (Rosmarinus officinalis) y sus componentes como fuente de antioxidantes dietéticos y agentes aromatizantes está en continuo crecimiento. El carnosol y el ácido carnósico, dos ... -
Role and therapeutic potential of dietary ketone bodies in lymph vessel growth.
(Nature, 2019-07-19)Los vasos linfáticos (LV), revestidos por células endoteliales linfáticas (LEC), son indispensables para la vida1. Sin embargo, el papel del metabolismo en las LEC no se ha dilucidado por completo. En el presente estudio, ... -
Toluquinol, a marine fungus metabolite, is a new angiosuppresor that interferes the Akt pathway.
García-Caballero, Melissa; Mari-Beffa, Manuel; Cañedo, Librada; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María (Elsevier, 2013-06-15)
El toluquinol, una metilhidroquinona producida por un hongo marino, fue seleccionado en el curso de una selección a ciegas de nuevos inhibidores potenciales de la angiogénesis. En el presente estudio proporcionamos la ... -
Dimethylfumarate Inhibits Angiogenesis In Vitro and In Vivo: A Possible Role for Its Antipsoriatic Effect?
García-Caballero, Melissa; Mari-Beffa, Manuel; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María (Elsevier, 2011-06-02)
Los ésteres de ácido fumárico (FAE) se han utilizado para el tratamiento oral de la psoriasis durante unos 50 años. Dado que una angiogénesis persistente y mantenida está asociada con varias enfermedades cutáneas, incluida ... -
A development of chimeric VEGFR2 TK inhibitor based on two ligand conformers from PDB: 1Y6A complex--medicinal chemistry consequences of a TKs analysis
Lintnerová, Lucia; García-Caballero, Melissa; Fridrich, Gregáň; Melicherčík, Milan; Rodríguez-Quesada, Ana María; Dobiaš, Juraj; Lác, Ján; Sališová, Marta; Boháč, Andrej[et al.] (Elsevier, 2014-01-24)
El VEGFR2 es un importante mediador de la angiogénesis e influye en el destino de algunas células madre cancerosas. Aquí analizamos las 34 estructuras de VEGFR2 TK disponibles en la base de datos PDB. De ellas, un complejo ... -
AMMO-Prot: Amine system project 3D-model finder
Navas-Delgado, Ismael; Pino-Ángeles, Almudena; Montañez, Raúl; Moya-García, Aurelio Ángel; Urdiales-Ruiz, José Luis; Sánchez-Jiménez, Francisca María; Aldana-Montes, José Francisco[et al.] (Springer Nature, 2008-04)
Background: Amines are biogenic amino acid derivatives, which play pleiotropic and very important yet complex roles in animal physiology. For many other relevant biomolecules, biochemical and molecular data are being ... -
Exploring and challenging the network of angiogenesis
Montañez, Raúl; Sánchez-Jiménez, Francisca María; Medina, Miguel Ángel; Rodríguez-Quesada, Ana María (Springer Nature, 2011-08-11)
Angiogenesis is one of the hallmarks of cancer and, as such, one of the alternative general targets for anticancer therapy. Since angiogenesis is a complex process involving a high number of interconnected components, a ... -
Spatial self-organization in hybrid models of multicellular adhesion.
(American Institute of Physics, 2016-10-26)Spatial self-organization emerges in distributed systems exhibiting local interactions when nonlinearities and the appropriate propagation of signals are at work. These kinds of phenomena can be modeled with different ... -
Spatial dynamics of synthetic microbial mutualists and their parasites.
(PLOS, 2017-08-21)A major force contributing to the emergence of novelty in nature is the presence of cooperative interactions, where two or more components of a system act in synergy, sometimes leading to higher-order, emergent phenomena. ... -
A bottom-up characterization of transfer functions for synthetic biology designs: lessons from enzymology
Carbonell-Ballesteros, Max; Durán-Nebreda, Salva; Montañez, Raúl; Macía, Javier; Rodríguez-Caso, Carlos Francisco (Oxfrod University Press, 2014-12-16)
Within the field of synthetic biology, a rational design of genetic parts should include a causal understanding of their input-output responses-the so-called transfer function-and how to tune them. However, a commonly ... -
Population dynamics of synthetic terraformation motifs.
(The Royal Society, 2018-07-04)Ecosystems are complex systems, currently experiencing several threats associated with global warming, intensive exploitation and human-driven habitat degradation. Because of a general presence of multiple stable states, ... -
Synthetic circuit designs for earth terraformation
(Springer Nature, 2015-07-18)Background: Mounting evidence indicates that our planet might experience runaway effects associated to rising temperatures and ecosystem overexploitation, leading to catastrophic shifts on short time scales. Remediation ... -
Emergence of proto-organisms from bistable stochastic differentiation and adhesion.
(The Royal Society, 2016-04-13)The rise of multicellularity in the early evolution of life represents a major challenge for evolutionary biology. Guidance for finding answers has emerged from disparate fields, from phylogenetics to modelling and synthetic ... -
Estudios de colocalización de las proteínas SYT6, ATG18a y EXO70D1 en A. thaliana.
Cardeñas Echevarría, Carlos; Moya-Barrientos, Miriam; Sánchez-Vera, Victoria; Ruiz-López, Noemí (2024)
Estudios recientes han identificado las proteínas SYT6, las cuales se localizan en puntos de contacto entre el retículo endoplasmático y vesículas secretoras gemadas del trans-Golgi network. Estas proteínas se caracterizan ... -
Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson-Gilford Progeria
(EMBO press, 2021-10-07)Inflammation is a hallmark of aging and accelerated aging syndromes such as Hutchinson-Gilford progeria syndrome (HGPS). In this study, we present evidence of increased expression of the components of the NLRP3 inflammasome ... -
Altered insulin secretion dynamics relate to oxidative stress and inflammasome activation in children with obesity and insulin resistance
(Springer Nature, 2023-08-20)Background: Insulin resistance (IR) is considered the main driver of obesity related metabolic complications, and is related to oxidative stress and inflammation, which in turn promote each other. There is currently no ... -
VUS next in rare diseases? Deciphering genetic determinants of biomolecular condensation
(BioMed Central, 2024-09-06)The diagnostic odysseys for rare disease patients are getting shorter as next-generation sequencing becomes more widespread. However, the complex genetic diversity and factors influencing expressivity continue to challenge ... -
Crucial Roles of Brassinosteroids in Cell Wall Composition and Structure Across Species: New Insights and Biotechnological Applications
Percio-Vargas, Francisco; Rubio-Valverde, Lourdes; Amorim-Silva, Vitor; Botella-Mesa, Miguel Ángel (Wiley, 2024)
Brassinosteroids (BR) are steroidal phytohormones essential for plant growth, development, and stress resistance. They fulfil this role partially by modulating cell wall structure and composition through the control of ... -
El papel de las proteínas NTMC2T5 en el desarrollo de plastos.
Las proteínas NTMC2T5 contienen un dominio SMP, por lo que se consideran proteínas transportadoras de lípidos. Recientemente, se ha demostrado que estas proteínas se localizan en la envuelta externa del cloroplasto e ...