Listar Biología Molecular y Bioquímica - (BMB) por fecha de publicación
Mostrando ítems 21-40 de 544
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Nucleolus size varies with sex, ploidy and gene dosage in insects
Montiel-Jiménez, Eugenia Elisabeth; Manrique-Poyato, María Inmaculada
; Rocha-Sánchez, Sonia María; López-León, María Dolores; Cabrero-Hurtado, Josefa; Perfectti-Álvarez, Francisco; Martínez-Camacho, Juan Pedro[et al.] (Wiley, 2012)
The nucleolus constitutes a cytologically visible phenotype for ribosomal DNA (rDNA). Nucleolar size, as determined by silver staining, is a good indicator of cell proliferation rate and biosynthetic activity. Nevertheless, ... -
Cocaine modulates both glutaminase gene expression and glutaminase activity in the brain of cocaine-sensitized mice
Blanco-Calvo, Eduardo; Campos-Sandoval, José Ángel; Palomino, Ana; Luque-Rojas, María Jesús; Bilbao, Ainhoa; Suárez, Juan; Márquez-Gómez, Javier; Rodriguez-de-Fonseca, Fernando[et al.] (Springer, 2012)
Glutaminase is considered the main Glutamate (Glu) producing enzyme. Two isoforms, liver (LGA) and kidney (KGA) type glutaminases have been identified in neurons. The role of both enzymes in psychopharmacological responses ... -
Attenuation of cocaine-induced conditioned locomotion is associated with altered expression of hippocampal glutamate receptors in mice lacking LPA1 receptors.
Blanco-Calvo, Eduardo; Bilbao, Ainhoa; Luque-Rojas, María Jesús; Palomino, Ana; Bermúdez Silva, Francisco Javier; Suárez-Pérez, Juan; Santín-Núñez, Luis Javier; Estivill-Torrús, Guillermo; Gutiérrez-Pérez, Antonia; Campos-Sandoval, José A.; Márquez-Gómez, Javier; Rodriguez-de-Fonseca, Fernando[et al.] (Springer, 2012)
Lysophosphatidic acid is a phospholipid mediator that modulates neurodevelopment and neurogenesis in the hippocampus through its actions on LPA1 receptors. Emerging evidences support LPA1 as a mediator of learning and ... -
Gene3D: a domain-based resource for comparative genomics, functional annotation and protein network analysis
(Oxford University Press, 2012-01)Gene3D http://gene3d.biochem.ucl.ac.uk is a comprehensive database of protein domain assignments for sequences from the major sequence databases. Domains are directly mapped from structures in the CATH database or predicted ... -
Genetic and genome-wide transcriptomic analyses identify co- regulation of oxidative response and hormone transcript abundance with vitamin C content in tomato fruit.
Lima-Silva, Viviana; Rosado, Abel; Amorim-Silva, Vitor; Muñoz-Mérida, Antonio; Pons, Clara; Bombarely, Aureliano; Trelles, Oswaldo; Fernández Muñoz, Rafael; Granell, Antonio; Valpuesta-Fernández, Victoriano; Botella-Mesa, Miguel Ángel[et al.] (BioMed Central, 2012-05-14)
L-ascorbic acid (AsA; vitamin C) is essential for all living plants where it functions as the main hydrosoluble antioxidant. It has diverse roles in the regulation of plant cell growth and expansion, photosynthesis, and ... -
Mammalian Glutaminase Gls2 Gene Encodes Two Functional Alternative Transcripts by a Surrogate Promoter Usage Mechanism.
Martín-Rufián, Mercedes; Tosina, Marta; Campos-Sandoval, José Ángel; Manzanares, Elisa; Lobo, Carolina; Segura-Checa, Juan Antonio; Alonso-Carrión, Francisco José; Mates-Sánchez, José Manuel; Márquez-Gómez, Javier[et al.] (PLOS, 2012-06-05)
Glutaminase is expressed in most mammalian tissues and cancer cells, but the regulation of its expression is poorly understood. An essential step to accomplish this goal is the characterization of its species- and cell-specific ... -
ReadqPCR and NormqPCR: R packages for the reading, quality checking and normalisation of RT-qPCR quantification cycle (Cq) data
(BMC, 2012-07)Background: Measuring gene transcription using real-time reverse transcription polymerase chain reaction (RT-qPCR) technology is a mainstay of molecular biology. Technologies now exist to measure the abundance of many ... -
Metabolic changes upon GLS inhibition by CB-839 in glioma cell lines
Santos Jiménez, Juan de los; Rosales, Tracy; Ko, Bookyung; Márquez-Gómez, Javier; Berardinis, Ralph J. de; Mates-Sánchez, José Manuel[et al.] (2012-07-19)
Many tumors use Gln for both energy generation and as a biosynthetic precursor. Glutaminases (GAs) catalyze the first step of glutaminolysis by converting glutamine (Gln) into glutamate and ammonia in the mitochondria. In ... -
Alteration of the Interconversion of Pyruvate and Malate in the Plastid or Cytosol of Ripening Tomato Fruit Invokes Diverse Consequences on Sugar But Similar Effects on Cellular Organic Acid, Metabolism, and Transitory Starch Accumulation.
Osorio-Algar, Sonia; Vallarino, José G.; Szecowka, Marek; Ufaz, Shai; Tzin, Vered; Angelovici, Ruthie; Galili, Gad; Fernie, Alisdair R.[et al.] (Oxford Academic, 2012-12-18)
The aim of this work was to investigate the effect of decreased cytosolic phosphoenolpyruvate carboxykinase (PEPCK) and plastidic NADP-dependent malic enzyme (NADP-ME) on tomato (Solanum lycopersicum) ripening. Transgenic ... -
Changes in the nuclear proteomic profiling of human glioblastoma cells after glutaminase overexpression
Márquez-Gómez, Javier; Cardona Ramírez, Carolina; Alonso-Carrión, Francisco José; Lobo, Carolina; Campos-Sandoval, José Ángel; Martín Rufián, Mercedes[et al.] (2013)
Human glutaminase (GA) enzymes are the products of two genes, GLS and GLS2. GA isozymes play markedly different roles in tumour biology: GLS isoforms (KGA and GAC) are related to cell growth and proliferation, whereas GLS2 ... -
Detection and Measurement of Necrosis in Plants.
Minina, Elena A.; Filonova, Lada H; Sánchez-Vera, Victoria; Suárez-Marín, María Fernanda; Daniel, Geoffrey; Bozhkov, Peter V.[et al.] (Humana Press, 2013)
Necrosis plays a fundamental role in plant physiology and pathology. When plants or plant cell cultures are subjected to abiotic stress they initiate rapid cell death with necrotic morphology. Likewise, when plants are ... -
Autophagy mediates caloric restriction-induced lifespan extension in Arabidopsis.
Minina, Alyona; Sánchez-Vera, Victoria; Moschou, Panagiotis N.; Suárez-Marín, María Fernanda; Sundberg, Eva; Weih, Martin; Bozhkov, Peter V.[et al.] (Aging Cell/Blackwell publishing Ltd/Anatomical Society of Great Britain and Ireland, 2013-01-17)
Caloric restriction (CR) extends lifespan in various heterotrophic organisms ranging from yeasts to mammals, but whether a similar phenomenon occurs in plants remains unknown. Plants are autotrophs and use their photosynthetic ... -
Anti-angiogenic properties of carnosol and carnosic acid, two major dietary compounds from rosemary.
López-Jiménez, Auxiliadora; García-Caballero, Melissa; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María (Springer, 2013-02-01)
Antecedentes: El uso de las hojas de romero (Rosmarinus officinalis) y sus componentes como fuente de antioxidantes dietéticos y agentes aromatizantes está en continuo crecimiento. El carnosol y el ácido carnósico, dos ... -
The SUD1 Gene Encodes a Putative E3 Ubiquitin Ligase and Is a Positive Regulator of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Activity in Arabidopsis.
G. Doblas, Verónica; Amorim-Silva, Vitor; Posé-Padilla, David; Rosado, Abel; Esteban, Alicia; Arró, Montserrat; Azevedo, Herlânder; Bombarely, Aureliano; Borsani, Omar; Valpuesta-Fernández, Victoriano; Ferrer, Albert; Tavares, Rui M.; Botella-Mesa, Miguel Ángel[et al.] (American Society of Plant Biologists, 2013-02-12)
The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) enzyme catalyzes the major rate-limiting step of the mevalonic acid (MVA) pathway from which sterols and other isoprenoids are synthesized. In contrast with our extensive ... -
Toluquinol, a marine fungus metabolite, is a new angiosuppresor that interferes the Akt pathway.
García-Caballero, Melissa; Mari-Beffa, Manuel; Cañedo, Librada; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María (Elsevier, 2013-06-15)
El toluquinol, una metilhidroquinona producida por un hongo marino, fue seleccionado en el curso de una selección a ciegas de nuevos inhibidores potenciales de la angiogénesis. En el presente estudio proporcionamos la ... -
Axonal neuregulin 1 is a rate limiting but not essential factor for nerve remyelination
(Oxford University Press, 2013-07)Neuregulin 1 acts as an axonal signal that regulates multiple aspects of Schwann cell development including the survival and migration of Schwann cell precursors, the ensheathment of axons and subsequent elaboration of the ... -
The molecular control of tomato fruit quality traits: the trade off between visual attributes, shelf life and nutritional value
Carneiro, RT; Lytovchenko, A; McQuinn, R; Vallarino Castro, José G.; Giovannoni, James J.; Fernie, Alisdair R; Rose, JKC; Osorio-Algar, Sonia[et al.] (2013-07-19)
Tomato (Solanum lycopersicum) is an established model to study fleshy fruit development and ripening and is an important crop in terms of its economic and nutritional value. Tomato fruit quality is a function of metabolite ... -
PainNetworks: A web-based resource for the visualisation of pain related genes in the context of their network associations.
(IASP/Wolters Kluwer, 2013-08-11)We now know of hundreds of genes that have some association with pain. Several genes have been shown to alter pain sensitivity in humans, and can be found in the OMIM database. The Pain Gene Database gives details of genes ... -
The coffee diterpene kahweol is an antitumoral compound for human estrogen receptor-negative breast cancer cells
Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María; Cárdenas García, Casimiro (SEBBM, 2013-09-04)
Although epidemiological studies indicate that coffee consumption is associated with a low incidence of several kinds of cancer, there are still few studies on the anti-tumoral effects of pure bioactive compounds isolated ... -
Ethylene signaling: simple ligand, complex regulation
(ELSEVIER, 2013-10)The hormone ethylene plays numerous roles in plant development. In the last few years the model of ethylene signaling has evolved from an initially largely linear route to a much more complex pathway with multiple feedback ...