Listar Biología Molecular y Bioquímica - (BMB) por título
Mostrando ítems 322-341 de 545
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Mammalian Glutaminase Gls2 Gene Encodes Two Functional Alternative Transcripts by a Surrogate Promoter Usage Mechanism.
Martín-Rufián, Mercedes; Tosina, Marta; Campos-Sandoval, José Ángel
; Manzanares, Elisa; Lobo, Carolina; Segura-Checa, Juan Antonio; Alonso-Carrión, Francisco José; Mates-Sánchez, José Manuel; Márquez-Gómez, Javier[et al.] (PLOS, 2012-06-05)
Glutaminase is expressed in most mammalian tissues and cancer cells, but the regulation of its expression is poorly understood. An essential step to accomplish this goal is the characterization of its species- and cell-specific ... -
Manejo de la anemia en el puerperio tras cesárea
(UMA Editorial, 2017-06-05)Según la Organización Mundial de la Salud (OMS) la anemia se define como valores de Hb menores de 12 g/dl en mujeres y de 13 g/dl en hombres (1). La anemia en el post-parto (APP) es una situación especial, y como tal tiene ... -
Manejo del estrés hídrico en aguacate: efectos en la productividad y en el control de la podredumbre blanca radicular
(UMA Editorial, 2022-07-14)España es el primer productor de aguacate en Europa, con más de 15000 hectáreas plantadas en 2020 y una producción de 99125 toneladas. Más del 80% de esta producción se concentra en la denominada Costa Subtropical Andaluza, ... -
MangoBase: a genomics portal and gene expression atlas for Mangifera indica
(MDPI, 2023-03-10)Mango (Mangifera indica L.) (2n = 40) is a member of the Anacardiaceae family, which was domesticated at least 4000 years ago in Asia. Mangoes are delicious fruits with great nutritional value. They are one of the major ... -
Marine sponge as a source of antiangiogenic compounds. The case of aeroplysinin-1
Rodríguez-Quesada, Ana María; Martínez-Póveda, Beatriz Amparo; Rodríguez-Nieto, S; Medina-Torres, Miguel Ángel (2014-04-02)
The vast majority of the natural compounds that have been previously described as inhibitors of angiogenesis have been isolated from plants and terrestrial microorganisms, mainly due to their higher availability and because ... -
Maritime pine PpMYB8 directly co-regulates secondary cell wall architecture and the associated Phe-biosynthesis pathway
De-la-Torre-Fazio, Fernando Nicolás; El-Azaz-Ciudad, Jorge; Pascual-Moreno, María Belén; Trontin, Jean-Francois; Debille, Sandrine; Canlet, Francis; Ávila-Sáez, Concepción; Cánovas-Ramos, Francisco Miguel[et al.] (2018-07-25)
Plants rely on the biosynthesis of L-Phenylalanine as building block for the synthesis of proteins but also as precursor for a tremendous range of plant-derived compounds essential for its grown, development and defense. ... -
Mathematical modeling of cancer metabolism
Medina-Torres, Miguel Ángel (2018-10-19)
Systemic approaches are needed and useful for the study of the very complex issue of cancer. Modeling has a central position in these systemic approaches. Metabolic reprogramming is nowadays acknowledged as an essential ... -
Mathematical Modeling of Polyamine Metabolism in Mammals.
Rodríguez-Caso, Carlos Francisco; Montañez, Raúl; Cascante, Marta; Sánchez-Jiménez, Francisca María; Medina-Torres, Miguel Ángel (Elsevier, 2006)
Polyamines are considered as essential compounds in living cells, since they are involved in cell proliferation, transcription, and translation processes. Furthermore, polyamine homeostasis is necessary to cell survival, ... -
Medida de glucosa en refrescos: una útil herramienta para ilustrar el aprendizaje de los fundamentos del análisis enzimático
Martínez-Póveda, Beatriz Amparo; García-Ponce, Ángel Luis; Blanco-López, Ángel; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María (2016-11-02)
Es indudable la relevancia que el análisis enzimático tiene en el ámbito de la Bioquímica, la Química Clínica y la Química de la Alimentación, entre otras. En la asignatura “Bioquímica Aplicada” de cuarto curso ... -
Metabolic Adjustments following Glutaminase Inhibition by CB-839 in Glioblastoma Cell Lines
De los Santos-Jiménez, Juan; Rosales, Tracy; Ko, Bookyung; Campos-Sandoval, José Ángel; Alonso-Carrión, Francisco José; Márquez-Gómez, Javier; DeBerardinis, Ralph J; Mates-Sánchez, José Manuel[et al.] (IOAP-MDPI, 2023-01-15)
Glioblastoma multiforme is the most common primary brain tumor. Unfortunately, it is also one of the cancer types that has the worst morbidity and mortality ratios, so new targets and treatments need to be found. The ... -
Metabolic changes through a bacterial enzyme Maleate Isomerase in transgenic Tomato plants reveal the role of organic acids in fruit quality and crop growth.
Jiménez, Lidia; Pott, Delphine; Martinez-Ferri, Elsa; Fernie, Alisdair R; Vallarino Castro, José G.; Osorio-Algar, Sonia[et al.] (2019-05-10)
Organic acids are of fundamental importance in all plant species. They have been clearly described to have roles as important as photosynthate, energy production, carbon storage, biosynthesis of amino acids, stomatal ... -
Metabolic changes upon GLS inhibition by CB-839 in glioma cell lines
Santos Jiménez, Juan de los; Rosales, Tracy; Ko, Bookyung; Márquez-Gómez, Javier; Berardinis, Ralph J. de; Mates-Sánchez, José Manuel[et al.] (2012-07-19)
Many tumors use Gln for both energy generation and as a biosynthetic precursor. Glutaminases (GAs) catalyze the first step of glutaminolysis by converting glutamine (Gln) into glutamate and ammonia in the mitochondria. In ... -
Metabolic channeling of phe for lignin biosynthesis in maritime pine
De-la-Torre-Fazio, Fernando Nicolás; El-Azaz-Ciudad, Jorge; Álvarez-Mena, Ana; Pascual-Moreno, María Belén; Trontin, J-F; Debille, Sandrine; Canlet, Francis; Ávila-Sáez, Concepción; Cánovas-Ramos, Francisco Miguel[et al.] (2017-07-14)
Phenylalanine (Phe) is the main precursor of phenylpropanoids biosynthesis in plants. This vast family of Phe-derived compounds can represent more than 30% of captured photosynthetic carbon, playing essential roles in ... -
Metabolic channelingof phe for lignin biosynthesis in maritime pine
El-Azaz-Ciudad, Jorge; De-la-Torre-Fazio, Fernando Nicolás; Pascual-Moreno, María Belén; Ávila-Sáez, Concepción; Cánovas-Ramos, Francisco Miguel (2016-09-02)
METABOLIC CHANNELING OF PHE FOR LIGNIN BIOSYNTHESIS IN MARITIME PINE Jorge El-Azaz, Fernando de la Torre, Belén Pascual, Concepción Ávila and Francisco M. Cánovas Departamento de Biología Molecular y Bioquímica, ... -
Metabolic impact of glutaminase isoenzymes modulation on glioma cell lines
De los Santos-Jiménez, Juan; Rosales, Tracy; Bookyung, Ko; Márquez-Gómez, Javier; DeBerardinis, Ralph J; Mates-Sánchez, José Manuel[et al.] (2022)
Many tumors use glutamine for both energy generation and as a biosynthetic precursor. Glutaminases (GAs) catalyze the first step of glutaminolysis by converting glutamine (Gln) into glutamate and ammonia in the mitochondria. ... -
Metabolic preference studies in cells of the tumor microenvironment
Ocaña Farfán, María del Carmen; Martínez-Póveda, Beatriz Amparo; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel (2016-10-03)
In the last years, the rediscovery of the Warburg effect and high tumoral glutaminolysis has lead to a renewed interest in cancer metabolism. Moreover, recent studies have put some importance in endothelial cells metabolism. ... -
Metabolic Reprogramming in Tumor Endothelial Cells.
(MDPI, 2022-09-21)The dynamic crosstalk between the different components of the tumor microenvironment is critical to determine cancer progression, metastatic dissemination, tumor immunity, and therapeutic responses. Angiogenesis is critical ... -
Metabolic Reprogramming is a Hallmark of Metabolism Itself
Medina-Torres, Miguel Ángel (2020-09-23)
The reprogramming of metabolism has been identified as one of the hallmarks of cancer. It is becoming more and more frequent to connect other diseases with metabolic reprogramming. This article aims to argue that metabolic ... -
Metabolic studies within the angiogenic microenvironment as a potential target for the treatment of cancer and other angiogenesis dependent diseases
(UMA Editorial, 2020-09-24)La angiogénesis es el proceso de formación de vasos sanguíneos a partir del lecho vascular preexistente. Una angiogénesis insuficiente o excesiva puede llevar al desarrollo de diversas patologías, entre las que se incluye ... -
Metabolism within the tumor microenvironment and its implication on cancer progression: an ongoing therapeutic target
Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel; Ocaña Farfán, María del Carmen; Rodríguez-Quesada, Ana María (2018-10-19)
Since reprogramming energy metabolism is considered a new hallmark of cancer, tumor metabolism is again in the spotlight of cancer research. Many studies have been carried out and many possible therapies have been developed ...