Listar BCGF - Artículos por tipo "info:eu-repo/semantics/submittedVersion"
Mostrando ítems 1-3 de 3
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Absence of LPA1 signaling results in defective cortical development
(Oxford academy, 2008-04)Lysophosphatidic acid (LPA) is a simple phospholipid with extracellular signaling properties mediated by specific G protein-coupled receptors. At least 2 LPA receptors, LPA(1) and LPA(2), are expressed in the developing ... -
Exploratory, anxiety and spatial memory impairments are dissociated in mice lacking the LPA1 receptor
(Elsevier, 2010-07)Lysophosphatidic acid (LPA) is a new, intercellular signalling molecule in the brain that has an important role in adult hippocampal plasticity. Mice lacking the LPA1 receptor exhibit motor, emotional and cognitive ... -
GDE2-RECK controls ADAM10 α-secretase-mediated cleavage of amyloid precursor protein
(American Association for the Advancement of Science, 2021-03)A disintegrin and metalloprotease 10 (ADAM10) is the α-secretase for amyloid precursor protein (APP). ADAM10 cleaves APP to generate neuroprotective soluble APPα (sAPPα), which precludes the generation of Aβ, a defining ...