Listar BCGF - Artículos por tipo "info:eu-repo/semantics/publishedVersion"
Mostrando ítems 1-20 de 118
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3D Biomimetic Porous Titanium (Ti6Al4V ELI) Scaffolds for Large Bone Critical Defect Reconstruction: An Experimental Study in Sheep
Crovace, Alberto Maria; Lacitignola, Luca; Monopoli Forleo, Donato; Staffieri, Francesco; Francioso, Edda; Di Meo, Antonio; Becerra-Ratia, José
; Crovace, Antonio; Santos-Ruiz, Leonor[et al.] (MDPI, 2020-08-11)
The main goal in the treatment of large bone defects is to guarantee a rapid loading of the affected limb. In this paper, the authors proposed a new reconstructive technique that proved to be suitable to reach this purpose ... -
41 Cases of Treatment of Cranial Cruciate Ligament Rupture with Porous TTA: Three Years of Follow Up
Trisciuzzi, Rodrigo; Fracassi, Laura; Afonso Martín, Hernando; Monopoli Forleo, Donato; Amat, Daniel; Santos-Ruiz, Leonor; De Palma, Elena; Crovace, Alberto Maria[et al.] (MDPI, 2019-02-20)
Tibial Tuberosity Advancement (TTA) is a surgical technique based on a linear osteotomy that determines a cranial advancement of the tibial tuberosity in patients suffering from cranial cruciate ligament rupture (CCL). The ... -
A Comparative Transcriptome Analysis of Avocado Embryogenic Lines Susceptible or Resistant to Rosellinia necatrix Exudate.
Moreno-Pérez, Ana; Zumaquero, Adela; Martinez-Ferri, Elsa; López-Herrera, Carlos; Pliego-Alfaro, Fernando; Palomo-Ríos, Elena; Pliego-Prieto, Clara[et al.] (MDPI, 2023-05-12)
Avocado embryogenic cultures were selected for resistance to the culture filtrate (CF) of Rosellinia necatrix, the causal agent of White Root Rot disease. A resistant callus line was obtained through recurrent selections ... -
A lysin motif effector subverts chitin-triggered immunity to facilitate arbuscular mycorrhizal symbiosis
Zeng, Tian; Rodríguez-Moreno, Luis Gabriel; Mansurkhodzaev, Artem; Wang, Peng; van den Berg, Willy; Gasciolli, Virginie; Cottaz, Sylvain; Fort, Sébastien; Thomma, Bart; Bono, Jean-Jaques; Bisseling, Ton; Limpens, Erik[et al.] (Wiley, 2020-01)
Arbuscular mycorrhizal (AM) fungi greatly improve mineral uptake by host plants in nutrient-depleted soil and can intracellularly colonize root cortex cells in the vast majority of higher plants. However, AM fungi possess ... -
A secreted LysM effector protects fungal hyphae through chitin-dependent homodimer polymerization.
Sánchez-Vallet, Andrea; Tian, Hui; Rodríguez-Moreno, Luis Gabriel; Valkenburg, Dirk-Jan; Saleem-Batcha, Raspudin; Wawra, Stephan; Kombrink, Anja; Verhage, Leonie; De Jonge, Ronnie; Van Esse, Peter; Zuccaro, Alga; Croll, Daniel; Mesters, Jeroen; Thomma, Bart[et al.] (Public Library of Science, 2020-06-23)
Plants trigger immune responses upon recognition of fungal cell wall chitin, followed by the release of various antimicrobials, including chitinase enzymes that hydrolyze chitin. In turn, many fungal pathogens secrete LysM ... -
Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus.
Sánchez-Varo, Raquel María; Trujillo-Estrada, Laura Isabel; Sánchez-Mejías, Elisabeth; Torres, Manuel; Baglietto-Vargas, David; Moreno-González, Inés; De Castro, Vanessa; Jiménez, Sebastián; Ruano, Diego; Vizuete, Marisa; Dávila-Cansino, José Carlos; García-Verdugo, José Manuel; Jiménez-Lara, Antonio Jesús; Vitorica, Javier; Gutiérrez-Pérez, Antonia[et al.] (Springer Nature, 2012)
Dystrophic neurites associated with amyloid plaques precede neuronal death and manifest early in Alzheimer’s disease (AD). In this work we have characterized the plaque-associated neuritic pathology in the hippocampus ... -
Activation of the JAK-STAT Signaling Pathway after In Vitro Stimulation with IFN beta in Multiple Sclerosis Patients According to the Therapeutic Response to IFN beta
Hurtado-Guerrero, Isaac; Pinto-Medel, María-Jesús; Urbaneja, Patricia; Rodríguez-Bada, José Luis; León, Antonio; Guerrero, Miguel; Fernández-Fernández, Óscar; Leyva-Fernández, Laura; Oliver-Martos, Begoña[et al.] (Public Library of Science, 2017)
Interferon beta (IFNß) is a common treatment used for multiple sclerosis (MS) which acts through the activation of the JAK-STAT pathway. However, this therapy is not always effective and currently there are no reliable ... -
Adipose tissue as a therapeutic target for vascular damage in Alzheimer's disease
Bettinetti-Luque, Miriam; Trujillo-Estrada, Laura Isabel; García-Fuentes, Eduardo; Andreo-López, Juana; Sánchez-Varo, Raquel María; Gómez-Mediavilla, Ángela; López, Manuela G.; Gutiérrez, Antonia; Baglietto-Vargas, David; Garrido-Sánchez, Lourdes; García-Caballero, Melissa[et al.] (Wiley, 2023-09-01)
Adipose tissue has recently been recognized as an important endocrine organ that plays a crucial role in energy metabolism and in the immune response in many metabolic tissues. With this regard, emerging evidence indicates ... -
Adipose tissue gene expression of factors related to lipid processing in obesity
Clemente-Postigo, María Mercedes; Queipo Ortuño, María Isabel; Fernandez-García, Diego; Gómez-Huelgas, Ricardo; Tinahones, Francisco J; Cardona, Fernando[et al.] (PLOS One, 2011)
Background Adipose tissue lipid storage and processing capacity can be a key factor for obesity-related metabolic disorders such as insulin resistance and diabetes. Lipid uptake is the first step to adipose tissue lipid ... -
Adipose tissue inflammation and VDR expression and methylation in colorectal cancer
Castellano-Castillo, Daniel; Morcillo Espina, Sonsoles; Clemente-Postigo, María Mercedes; Crujeiras Martínez, Ana Belén; Fernández-García, José Carlos; Torres Sánchez, Esperanza; Tinahones-Madueño, Francisco José; Macías-González, Manuel[et al.] (BMC (Part of Springer Nature), 2018)
Background: Lack of vitamin D (VD) has been associated with colorectal cancer (CRC). VD has anti-inflammatory effects and regulates several cellular pathways by means of its receptor, including epigenetic modifications. ... -
Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer mouse model.
Jiménez, Sebastián; Torres, Manuel; Vizuete, Marisa; Sánchez-Varo, Raquel María; Sánchez-Mejías, Elisabeth; Trujillo-Estrada, Laura Isabel; Carmona-Cuenca, Irene; Caballero, Cristina; Ruano, Diego; Gutiérrez-Pérez, Antonia; Vitorica, Javier[et al.] (Elsevier, 2011-05)
Neurotrophins, activating the PI3K/Akt signaling pathway, control neuronal survival and plasticity. Alterations in NGF, BDNF, IGF-1, or insulin signaling are implicated in the pathogenesis of Alzheimer disease. We have ... -
Amyloid-beta impairs TOM1-mediated IL-1R1 signaling
Cadete Martini, Alessandra; Gomez-Arboledas, Angela; Forner, Stefania; Rodriguez-Ortiz, Carlos; McQuade, Amanda; Danhash, Emma; Phan, Jimmy; Javoncillo, Dominic; Ha, Jordan-Vu; Tram, Melanie; Trujillo-Estrada, Laura Isabel; da Cunha, Celia; Ager, Rahasson; Davila, Jose Carlos; Kitazawa, Masashi; Blurton-Jones, Mathew; Gutierrez, Antonia; Baglietto-Vargas, David; Medeiros, Rodrigo; LaFerla, Frank M[et al.] (National Academy of Sciences, 2019-10)
Defects in interleukin-1β (IL-1β)-mediated cellular responses contribute to Alzheimer's disease (AD). To decipher the mechanism associated with its pathogenesis, we investigated the molecular events associated with the ... -
Amyloid-β impairs the phagocytosis of dystrophic synapses by astrocytes in Alzheimer's disease.
Sanchez-Mico, Maria Virtudes; Jiménez, Sebastián; Gómez-Arboledas, Ángela; Muñoz-Castro, Clara; Romero-Molina, Carmen; Navarro, Victoria; Sánchez-Mejías, Elisabeth; Núñez-Díaz, Cristina; Sánchez-Varo, Raquel María; Galea, Elena; Dávila-Cansino, José Carlos; Vizuete, Marisa; Gutiérrez-Pérez, Antonia; Vitorica, Javier[et al.] (Wiley, 2020-12-07)
Reactive astrocytes and dystrophic neurites, most aberrant presynaptic elements, are found surrounding amyloid-β plaques in Alzheimer's disease (AD). We have previously shown that reactive astrocytes enwrap, phagocytose, ... -
An immune receptor complex evolved in soybean to perceive a polymorphic bacterial flagellin
(Springer Nature, 2020-07-28)In both animals and plants, the perception of bacterial flagella by immune receptors elicits the activation of defence responses. Most plants are able to perceive the highly conserved epitope flg22 from flagellin, the main ... -
Analysis of the role of the type III effector inventory of Pseudomonas syringae pv. phaseolicola 1448a in interaction with the plant.
Zumaquero, Adela; Macho, Alberto P; Rufián Plaza, José Sebastián; Beuzón-López, Carmen del Rosario (American Society for Microbiology, 2010-06-23)
In Pseudomonas syringae, the type III secretion system (T3SS) is essential for disease in compatible hosts and for eliciting the hypersensitive response in incompatible hosts. P. syringae pathovars secrete a variable number ... -
Antiviral, Immunomodulatory and Antiproliferative Activities of Recombinant Soluble IFNAR2 without IFN-ß Mediation
Hurtado-Guerrero, Isaac; Hernáez, Bruno; Pinto-Medel, Maria Jesús; Calonge, Esther; Rodríguez-Bada, José Luis; Urbaneja, Patricia; Alonso, Ana; Mena-Vázquez, Natalia; Aliaga, Pablo; Issazadeh-Navikas, Shohreh; Pavía-Molina, José; Leyva-Fernández, Laura; Alcamí, José; Alcamí, Antonio; Fernández-Fernández, Óscar; Oliver-Martos, Begoña[et al.] (MDPI, 2020)
Soluble receptors of cytokines are able to modify cytokine activities and therefore the immune system, and some have intrinsic biological activities without mediation from their cytokines. The soluble interferon beta (IFN-ß) ... -
Anxiety‑like behavior and microglial activation in the amygdala after acute neuroinflammation induced by microbial neuraminidase.
León-Rodríguez, Ana; Fernández-Arjona, María del Mar; Mateos-Grondona, Jesús; Pedraza-Benítez, María del Carmen; López-Ávalos, María Dolores (Springer Nature, 2022-07-08)
Short-term behavioral alterations are associated with infection and aid the recovery from sickness. However, concerns have raised that sustained behavioral disturbances after acute neuroinflammation could relate to ... -
Arabidopsis NahG Plants as a Suitable and Efficient System for Transient Expression using Agrobacterium tumefaciens
Rosas-Díaz, Tábata Victoria; Cana Quijada, José Francisco; Amorim-Silva, Vitor; Botella-Mesa, Miguel Ángel; Lozano Durán, Rosa; Bejarano, Eduardo R.[et al.] (Science direct, 2017-02)
aken together, our results show that expression of the NahG transgene in Arabidopsis dramatically enhances the efficiency of Agrobacterium-mediated transformation in rosette leaves, enabling the routine use of this technique ... -
Ascorbic acid and its transporter SVCT2, affect radial glia cells differentiation in postnatal stages
Saldivia, Natalia; Salazar, Katterine; Cifuentes-Rueda, Manuel; Espinoza, Francisca; Harrison, Fiona E.; Nualart, Francisco[et al.] (Wiley, 2024-01-05)
Radial glia (RG) cells generate neurons and glial cells that make up the cerebral cortex. Both in rodents and humans, these stem cells remain for a specific time after birth, named late radial glia (lRG). The knowledge of ... -
Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8+ T cells
(CELLPRESS, 2021)Autotaxin (ATX; ENPP2) produces lysophosphatidic acid (LPA) that regulates multiple biological functions via cognate G protein-coupled receptors LPAR1-6. ATX/LPA promotes tumor cell migration and metastasis via LPAR1 and ...