Listar BCGF - Artículos por tipo "info:eu-repo/semantics/acceptedVersion"
Mostrando ítems 1-20 de 36
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A Bacterial Effector Protein Hijacks Plant Metabolism to Support Pathogen Nutrition.
(Cell Press, 2020)Many bacterial plant pathogens employ a type III secretion system to inject effector proteins within plant cells to suppress plant immunity. Whether and how effector proteins also co-opt plant metabolism to support extensive ... -
A collagen-targeted biomimetic RGD peptide to promote osteogenesis
Visser, Rick
; Arrabal-García, Pilar María; Santos-Ruiz, Leonor; Fernández-Barranco, Raúl; Becerra-Ratia, José; Cifuentes-Rueda, Manuel[et al.] (MARY ANN LIEBERT, INC, 2014-01)
Osteogenesis is a complex, multifactorial process in which many different signals interact. The bone morphogenetic proteins (BMPs) are the most potent inducers of osteoblastic differentiation, although very high doses of ... -
A Cysteine-Rich Protein Kinase Associates with a Membrane Immune Complex and the Cysteine Residues Are Required for Cell Death
(Oxford University Press, 2017-01)Membrane-localized proteins perceive and respond to biotic and abiotic stresses. We performed quantitative proteomics on plasma membrane-enriched samples from Arabidopsis (Arabidopsis thaliana) treated with bacterial ... -
A Defense Pathway Linking Plasma Membrane and Chloroplasts and Co-opted by Pathogens
(Elsevier, 2020-07)Chloroplasts are crucial players in the activation of defensive hormonal responses during plant-pathogen interactions. Here, we show that a plant virus-encoded protein re-localizes from the plasma membrane to chloroplasts ... -
A virus-targeted plant receptor-like kinase promotes cell-to-cell spread of RNAi
Rosas Díaz; Dan, Zhanga; Fan, Pengfei; Liping, Wang; Xue, Ding; Yuli, Jiang; Jiménez-Góngora, Tamara; Medina-Puche, Laura; Xinyan, Zhao; Zhengyan, Feng; Guiping, Zhang; Xiaokun, Liuc; Rodríguez-Bejarano, Eduardo; Li, Tana; Heng, Zhang; Jian-Kang, Zhua; Weiman, Xinga; Faulkner, Christine; Shingo, Nagawa; Lozano Durán, Rosa[et al.] (PNAS, 2018-01-23)
RNA interference (RNAi) in plants can move from cell to cell, allowing for systemic spread of an antiviral immune response. How this cell-to-cell spread of silencing is regulated is currently unknown. Here, we describe ... -
Adipogenic Impairment of Adipose Tissue-Derived Mesenchymal Stem Cells in Subjects With Metabolic Syndrome: Possible Protective Role of FGF2
Oliva Olivera, Wilfredo; Coín-Aragüez, Leticia I.; Lhamyani, Said; Clemente-Postigo, María Mercedes; Alcaide Torres, Juan; Bernal-López, María Rosa; El-Bekay, Rajaa; Tinahones-Madueño, Francisco José[et al.] (Endocrine Society, 2017)
Context: The decreased expansion capacity of adipose tissue plays a crucial role in the onset of disorders associated with metabolic syndrome. Objetive: The aim of this study was to examine the state of adipose tissue-derived ... -
Arabidopsis thaliana, an experimental host for tomato yellow leaf curl disease-associated begomoviruses by agroinoculation and whitefly transmission.
Cañizares, María del Carmen; Rosas-Díaz, Tábata Victoria; Rodríguez-Negrete, Edgar; Hogenhoutc, S. A; Bedford, I. D.; Rodríguez-Bejarano, Eduardo; Navas-Castillo, Jesús; Moriones, Enrique[et al.] (British Society for Plant Pathology, 2014-07-01)
Tomato yellow leaf curl disease is one of the most devastating viral diseases affecting tomato crops worldwide. This disease is caused by several begomoviruses (genus Begomovirus, family Geminiviridae), such as Tomato ... -
Behavioral phenotype of maLPA1-null mice: increased anxiety-like behavior and spatial memory deficits
Santín-Núñez, Luis Javier; Bilbao, Ainhoa; Pedraza-Benítez, María del Carmen; Matas-Rico, Elisa; López-Barroso, Diana; Castilla-Ortega, María Estela; Sánchez-López, Jorge; Riquelme, Raquel; Varela Nieto, Isabel; de la Villa, P.; Surdiaz, Margarita; Chun, Jerold; Rodríguez de Fonseca, Fernando; Estivill-Torrús, Guillermo[et al.] (Wiley, 2009-11)
Lysophosphatidic acid (LPA) has emerged as a new regulatory molecule in the brain. Recently, some studies have shown a role for this molecule and its LPA1 receptor in the regulation of plasticity and neurogenesis in the ... -
Competitive Index: Mixed Infection-Based Virulence Assays for Genetic Analysis in Pseudomonas syringae-Plant Interactions.
Macho, Alberto P; Rufián, José S.; Ruiz-Albert, Francisco Javier; Beuzón-López, Carmen del Rosario (Humana Press, New York, NY, 2016)
When studying bacterial plant pathogens, the genetic analysis of the contribution of virulence factors to the infection process has traditionally been hindered by their high degree of functional redundancy. In recent years, ... -
Decreased soluble IFN-β receptor (sIFNAR2) in multiple sclerosis patients: A potential serum diagnostic biomarker
Órpez-Zafra, Teresa; Pavía-Molina, José; Hurtado-Guerrero, Isaac; Pinto-Medel, Maria Jesús; Rodríguez-Bada, José Luis; Urbaneja, Patricia; Suardíaz García, Margarita; Villar, Luisa M; Comabella, Manuel; Montalban, Xavier; Alvarez-Cermeño, Jose C; Leyva-Fernández, Laura; Fernández-Fernández, Óscar; Oliver-Martos, Begoña[et al.] (SAGE Journals, 2017)
Background: The soluble isoform of the interferon-β (IFN-β) receptor (sIFNAR2) could modulate the activity of both endogenous and systemically administered IFN-β. Previously, we described lower serum sIFNAR2 levels in ... -
Development and validation of an ELISA for quantification of soluble IFN-β receptor: assessment in multiple sclerosis
Órpez-Zafra, Teresa; Pavía-Molina, José; Pinto-Medel, Maria Jesús; Hurtado-Guerrero, Isaac; Rodríguez-Bada, José Luis; Martín-Montañez, Elisa; Fernández Fernández, Óscar; Leyva-Fernández, Laura; Oliver-Martos, Begoña[et al.] (Taylor & Francis, 2015)
Aim: The soluble isoform of the IFN-β receptor (sIFNAR2) can bind IFN-β and modulate its activity, although its role in autoimmune diseases remains unknown. Methods: A recombinant human sIFNAR2 protein was cloned, ... -
Early development of anti-natalizumab antibodies in MS patients
Oliver-Martos, Begoña; Órpez, Teresa; Urbaneja, Patricia; Maldonado-Sanchez, Rafael; Leyva-Fernández, Laura; Fernández Fernández, Óscar[et al.] (SpringerLink, 2013)
The purpose of this study is to monitor the development of anti-natalizumab antibodies to evaluate their first appearance in multiple sclerosis patients, since their presence has been associated with a reduction in the ... -
Effects of glucagon-like peptide-1 on the differentiation and metabolism of human adipocytes.
El-Bekay, Rajaa; Coín-Aragüez, Leticia I.; Fernandez-García, Diego; Oliva Olivera, Wilfredo; Bernal-López, María Rosa; Clemente-Postigo, María Mercedes; Delgado-Lista, Javier; Díaz-Ruiz, Alberto; Guzmán-Ruiz, Rocio; Vázquez-Martínez, Rafael; Lhamyani, Said; Roca-Rodríguez, María del Mar; Fernández-Veledo, Sonia; Vendrell, Joan; Malagón, Maria M.; Tinahones-Madueño, Francisco José[et al.] (British Pharmacological Society, 2016-03-18)
Glucagon-like peptide-1 (GLP-1) analogues improve glycaemic control in type 2 diabetic (T2D) patients and cause weight loss in obese subjects by as yet unknown mechanisms. We recently demonstrated that the GLP-1 receptor, ... -
Expression of Gls and Gls2 glutaminase isoforms in astrocytes
Cardona, Carolina; Sánchez-Mejías, Elisabeth; Dávila-Cansino, José Carlos; Martín-Rufián, Mercedes; Campos-Sandoval, José Ángel; Vitorica, Javier; Alonso-Carrión, Francisco José; Mates-Sánchez, José Manuel; Segura-Checa, Juan Antonio; Norenberg, Michael D.; Rama Rao, Kakulavarapu V.; Jayakumar, Arumugan R.; Gutiérrez-Pérez, Antonia; Márquez-Gómez, Javier[et al.] (Wiley, 2015-03)
The expression of glutaminase in glial cells has been a controversial issue and matter of debate for many years. Actually, glu-taminase is essentially considered as a neuronal marker in brain. Astrocytes are endowed with ... -
Functional Analysis of Gene-Silencing Suppressors from Tomato Yellow Leaf Curl Disease Viruses
Pérez-Luna, Ana Isabel; Morilla, Gabriel; Voinnet, Olivier; Rodríguez-Bejarano, Eduardo (APS Publications, 2012-06-01)
Tomato yellow leaf curl disease (TYLCD) is caused by a complex of phylogenetically related Begomovirus spp. that produce similar symptoms when they infect tomato plants but have different host ranges. In this work, we ... -
GABAergic deficits in absence of LPA1 receptor, associated anxiety-like and coping behaviors, and amelioration by interneuron precursor transplants into the dorsal hippocampus
Rosell-Valle, Cristina; Martínez-Losa, Magdalena; Matas-Rico, Elisa; Castilla-Ortega, María Estela; Zambrana-Infantes, Emma; Gómez-Conde, Ana Isabel; Sánchez-Salido, Lourdes; Ladrón de Guevara-Miranda, David; Pedraza-Benítez, María del Carmen; Serrano-Castro, Pedro Jesús; Chun, Jerold; Rodríguez de Fonseca, Fernando; Álvarez Dolado, Manuel; Santín-Núñez, Luis Javier; Estivill-Torrús, Guillermo[et al.] (Springer Link, 2021-04-01)
Defects in GABAergic function can cause anxiety- and depression-like behaviors among other neuropsychiatric disorders. Therapeutic strategies using the transplantation of GABAergic interneuron progenitors derived from the ... -
Geminiviruses Subvert Ubiquitination by Altering CSN-Mediated Derubylation of SCF E3 Ligase Complexes and Inhibit Jasmonate Signaling in Arabidopsis thaliana
Lozano-Durán, Rosa; Rosas-Díaz, Tábata Victoria; Gusmaroli, Giuliana; Pérez-Luna, Ana Isabel; Taconnat, Ludivine; Wang Deng, Xing; Rodríguez-Bejarano, Eduardo[et al.] (Oxford Academy, 2011-03)
Viruses must create a suitable cell environment and elude defense mechanisms, which likely involves interactions with host proteins and subsequent interference with or usurpation of cellularmachinery. Here, we describe a ... -
Gene expression in IFNß signalling pathway differs between monocytes, CD4 and CD8 T cells from MS patients
Oliver-Martos, Begoña; Órpez, Teresa; Pinto-Medel, Maria Jesús; Mayorga Mayorga, Cristobalina; García-León, Juan Antonio; Maldonado-Sanchez, Rafael; Suardíaz García, Margarita; Guerrero, Miguel; Luque, Gloria; Leyva-Fernández, Laura; Fernández Fernández, Óscar[et al.] (Elsevier, 2011)
IFNß exerts its activity through the interaction with IFNAR, through activation of the JAK/STAT pathway. We analyzed the changes in IFNAR1, IFNAR2, STAT1, STAT2, Tyk2, JAK1, IRF9 and MxA gene expressions after prolonged ... -
Gene therapy with mesenchymal stem cells expressing IFN-ß ameliorates neuroinflammation in experimental models of multiple sclerosis
Marín Bañasco, Carmen; Benabdellah, K; Melero-Jerez, C; Oliver-Martos, Begoña; Pinto-Medel, Maria Jesús; Hurtado-Guerrero, Isaac; de Castro, Fernando; Clemente, Diego; Fernández-Fernández, Óscar; Martín, F; Leyva-Fernández, Laura; Suardíaz García, Margarita[et al.] (British Pharmacological Society, 2017)
Background and purpose: Recombinant IFN-ß is one of the first-line treatments in multiple sclerosis (MS), despite its lack of efficacy in some patients. In this context, mesenchymal stem cells (MSCs) represent a promising ... -
IFNAR1 and IFNAR2 polymorphisms confer susceptibility to multiple sclerosis but not to interferon-beta treatment response.
Leyva-Fernández, Laura; Fernández-Fernández, Óscar; Fedetz, María; Blanco, Eva; Fernández, Victoria E.; Oliver-Martos, Begoña; León, Antonio; Pinto-Medel, María Jesús; Mayorga Mayorga, Cristobalina; Guerrero, Miguel; Luque, Gloria; Alcina, Antonio; Matesanz, Fuencisla[et al.] (Elsevier, 2005-04-22)
We investigated the role of three polymorphisms in the IFNAR1 (SNPs 18417 and -408) and IFNAR2 (SNP 11876) genes in multiple sclerosis (MS) susceptibility and in the IFNβ treatment response in a group of 147 patients and ...