Listar BCGF - Artículos por tipo "info:eu-repo/semantics/publishedVersion"
Mostrando ítems 21-40 de 132
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Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8+ T cells
(CELLPRESS, 2021)Autotaxin (ATX; ENPP2) produces lysophosphatidic acid (LPA) that regulates multiple biological functions via cognate G protein-coupled receptors LPAR1-6. ATX/LPA promotes tumor cell migration and metastasis via LPAR1 and ... -
Basal Sodium-Dependent Vitamin C Transporter 2 polarization in choroid plexus explant cells in normal or scorbutic conditions
Ulloa, Viviana; Saldivia, Natalia; Ferrada, Luciano; Salazar, Katherine; Martínez, Fernando; Silva-Álvarez, Carmen; Magdalena, Rocío; Oviedo, María José; Montecinos, Hernán; Torres-Vergara, Pablo; Cifuentes-Rueda, Manuel
; Nualart, Francisco[et al.] (Springer Nature, 2019-10)
Vitamin C is incorporated into the cerebrospinal fluid (CSF) through choroid plexus cells. While the transfer of vitamin C from the blood to the brain has been studied functionally, the vitamin C transporter, SVCT2, has ... -
Basic fibroblast growth factor enhances the osteogenic differentiation induced by bone morphogenetic protein-6 in vitro and in vivo
Visser, Rick; Arrabal-García, Pilar María; Santos-Ruiz, Leonor; Becerra-Ratia, José; Cifuentes-Rueda, Manuel (ELSEVIER, 2012-04)
Some members of the bone morphogenetic protein subfamily (BMP-2 and -7) are currently used in orthopedic surgery for several applications. Although their use is considered safe at short term, the high doses of growth factors ... -
Biallelic mutations in LAMA5 disrupts a skeletal noncanonical focal adhesion pathway and produces a distinct bent bone dysplasia.
(Elsevier, 2020-11-23)Background Beyond its structural role in the skeleton, the extracellular matrix (ECM), particularly basement membrane proteins, facilitates communication with intracellular signaling pathways and cell to cell interactions ... -
Calretinin Interneurons are Early Targets of Extracellular Amyloid-beta Pathology in PS1/AbetaPP Alzheimer Mice Hippocampus.
Baglietto-Vargas, David; Moreno-González, Inés; Sánchez-Varo, Raquel María; Jiménez, Sebastián; Trujillo-Estrada, Laura Isabel; Sánchez-Mejías, Elisabeth; Torres, Manuel; Romero-Acebal, Manuel; Ruano, Diego; Vizuete, Marisa; Vitorica, Javier; Gutiérrez-Pérez, Antonia[et al.] (IOS Press, 2010-07-08)
Specific neuronal networks are preferentially affected in the early stages of Alzheimer’s disease (AD). The distinct subpopulations of hippocampal inhibitory GABAergic system have been shown to display differential ... -
Characterization of Curtovirus V2 Protein, a Functional Homolog of Begomovirus V2
Pérez-Luna, Ana Isabel; Romero-Rodríguez, Beatriz; Rosas-Díaz, Tábata Victoria; Cerero, Laura; Rodríguez Negrete, Edgar A.; Castillo-Garriga, Araceli; Rodríguez-Bejarano, Eduardo[et al.] (Frontiers, 2020-06-19)
Geminiviruses are single-stranded DNA plant viruses with circular genomes packaged within geminate particles. Among the Geminiviridae family, Begomovirus and Curtovirus comprise the two best characterized genera. Curtovirus ... -
Comparative analysis and characterization of soluble factors and exosomes from cultured adipose tissue and bone marrow mesenchymal stem cells in canine species
Villatoro, Antonio J; Alcoholado Cueto, Cristina; Martín Astorga, María del Carmen; Fernández, V.; Cifuentes-Rueda, Manuel; Becerra-Ratia, José[et al.] (Elsevier, 2019-02)
The two main sources of mesenchymal stem cell (MSCs) in the canine species are bone marrow (cBM-MSCs) and adipose tissue (cAd-MSCs). The secretion of multitude bioactive molecules, included under the concept of secretome ... -
Comprehensive Tissue-Specific Transcriptome Analysis Reveals Distinct Regulatory Programs during Early Tomato Fruit Development
(Oxford Academy, 2015-06-22)Fruit formation and early development involve a range of physiological and morphological transformations of the various constituent tissues of the ovary. These developmental changes vary considerably according to tissue ... -
Confocal microscopy reveals in planta dynamic interactions between pathogenic, avirulent and non-pathogenic Pseudomonas syringae strains.
Rufián Plaza, José Sebastián; Macho, Alberto P; Corry, David S; Mansfield, John W; Ruiz-Albert, Francisco Javier; Arnold, Dawn L.; Beuzón-López, Carmen del Rosario[et al.] (Wiley, 2018)
Recent advances in genomics and single-cell analysis have demonstrated the extraordinary complexity reached by microbial populations within their hosts. Communities range from complex multispecies groups to homogeneous ... -
Correction to: Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease.
Boza-Serrano, Antonio; Ruiz, Rocío; Sánchez-Varo, Raquel María; García-Revilla, Juan; Yang, Yiyi; Jiménez-Ferrer, Itzia; Paulus, Agnes; Wennström, Malin; Vilalta, Anna; Allendorf, David; Dávila-Cansino, José Carlos; Stegmayr, John; Jiménez, Sebastián; Roca-Ceballos, Maria A.; Navarro-Garrido, Victoria; Swanberg, Maria; Hsieh, Christine L; Real-Navarrete, Luis Miguel; Englund, Elisabeth; Linse, Sara; Leffler, Hakon; Nilsson, Ulf J.; Brown, Guy C; Gutiérrez-Pérez, Antonia; Vitorica, Javier; Venero, José Luis; Deierborg, Thomas[et al.] (Springer, 2023-02-15)
Alzheimer's disease (AD) is a progressive neurodegenerative disease in which the formation of extracellular aggregates of amyloid beta (Aβ) peptide, fibrillary tangles of intraneuronal tau and microglial activation are ... -
Cross-reactivity of antibodies against interferon beta in multiple sclerosis patients and interference of the JAK-STAT signaling pathway
Hurtado-Guerrero, Isaac; Pinto-Medel, Maria Jesus; Urbaneja, Patricia; Rodríguez-Bada, José Luis; Ortega-Pinazo, Jesús; Serrano-Castro, Pedro Jesús; Fernández-Fernández, Óscar; Leyva-Fernández, Laura; Oliver-Martos, Begoña[et al.] (Nature, 2017)
Interferon beta (IFNβ) therapy has immunogenic properties and induces the development of neutralizing antibodies (NAbs). From the extensive literature focused in the development of NAbs in multiple sclerosis (MS) patients, ... -
Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus.
Torres, Manuel; Jiménez, Sebastián; Sánchez-Varo, Raquel María; Navarro, Victoria; Trujillo-Estrada, Laura Isabel; Sánchez-Mejías, Elisabeth; Carmona, Irene; Dávila-Cansino, José Carlos; Vizuete, Marisa; Gutiérrez-Pérez, Antonia; Vitorica, Javier[et al.] (Springer Nature, 2012-11-22)
Axonal pathology might constitute one of the earliest manifestations of Alzheimer disease. Axonal dystrophies were observed in patients and transgenic models. These dystrophies could reflect the disruption of axonal transport ... -
Dendritic scaffold onto titanium implants. A versatile strategy increasing biocompatibility.
Molina, Noemí; González, Ana; Monopoli, Donato; Mentado, Belinda; Becerra-Ratia, José; Santos-Ruiz, Leonor; Vida-Pol, Yolanda; Pérez-Inestrosa, Ezequiel[et al.] (MDPI, 2020-04-01)
Osseointegration of metal prosthetic implants is a yet unresolved clinical need that depends on the interplay between the implant surface and bone cells. The lack of a relationship between bone cells and metal has traditionally ... -
Diagnosis of immediate reactions to amoxicillin: Comparison of basophil activation markers CD63 and CD203c in a prospective study
Céspedes Lagos, José Antonio; Fernández-Santamaría, Rubén; Ariza Veguillas, Adriana; Bogas Herrera, Gádor; Doña, Inmaculada; Rondón, Carmen; Salas, María; Labella, Marina; Frecha, Cecilia; Mayorga Mayorga, Cristobalina; Torres-Jaén, María Josefa; Fernández-Duarte, Tahía Diana[et al.] (Wiley, 2022-12-07)
Amoxicillin (AX) combined or not with clavulanic acid (CLV) is frequently involved in IgE-mediated reactions. Drug provocation test (DPT) is considered as the gold standard for diagnosis, although contraindicated in high-risk ... -
Dietary administration of D-chiro-inositol attenuates sex-specific metabolic imbalances in the 5xFAD mouse model of Alzheimer’s disease
López-Gambero, Antonio J.; Pacheco-Sánchez, Beatriz; Rosell-del-Valle, Cristina; Medina-Vera, Dina; Navarro, Juan Antonio; Fernández-Arjona, María del Mar; De Ceglia, Marialuisa; Sanjuán-Solís, Jesús Carlos; Simon, Vincent; Cota, Daniela; Rivera, Patricia; Rodriguez-de-Fonseca, Fernando; Suárez-Pérez, Juan[et al.] (Elsevier, 2022-06)
Increasing evidence shows that hypothalamic dysfunction, insulin resistance, and weight loss precede and progress along with the cognitive decline in sporadic Alzheimer’s Disease (AD) with sex differences. This study aimed ... -
Discovering Host Genes Involved in the Infection by the Tomato Yellow Leaf Curl Virus Complex and in the Establishment of Resistance to the Virus Using Tobacco Rattle Virus-based Post Transcriptional Gene Silencing
Henryk Czosnek; Assaf Eybishtz; Dagan Sade; Rena Gorovits; Iris Sobol; Rodríguez-Bejarano, Eduardo; Rosas-Díaz, Tábata Victoria; Lozano Durán, Rosa[et al.] (MDPI, 2013-02)
The development of high-throughput technologies allows for evaluating gene expression at the whole-genome level. Together with proteomic and metabolomic studies, these analyses have resulted in the identification of plant ... -
Distinct disease-sensitive GABAergic neurons in the perirhinal cortex of Alzheimer's mice and patients
Sánchez-Mejías, Elisabeth; Núñez-Díaz, Cristina; Sánchez-Varo, Raquel María; Gómez-Arboledas, Ángela; García-León, Juan Antonio; Fernández-Valenzuela, Juan José; Mejías-Ortega, Marina; Trujillo-Estrada, Laura Isabel; Baglietto-Vargas, David; Moreno-González, Inés; Dávila-Cansino, José Carlos; Vitorica, Javier; Gutiérrez-Pérez, Antonia[et al.] (Wiley, 2020-03)
Neuronal loss is the best neuropathological substrate that correlates with cortical atrophy and dementia in Alzheimer's disease (AD). Defective GABAergic neuronal functions may lead to cortical network hyperactivity and ... -
Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology.
Romero-Molina, Carmen; Navarro, Victoria; Sánchez-Varo, Raquel María; Jiménez, Sebastián; Fernández-Valenzuela, Juan José; Sanchez-Mico, Maria Virtudes; Muñoz-Castro, Clara; Gutiérrez-Pérez, Antonia; Vitorica, Javier; Vizuete, Marisa[et al.] (Frontiers, 2018-11-14)
Microglial cells are crucial players in the pathological process of neurodegenerative diseases, such as Alzheimer's disease (AD). Microglial response in AD has been principally studied in relation to amyloid-beta pathology ... -
Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer's disease.
Baglietto-Vargas, David; Sánchez-Mejías, Elisabeth; Navarro, Victoria; Jiménez, Sebastián; Trujillo-Estrada, Laura Isabel; Gómez-Arboledas, Ángela; Sanchez-Mico, Maria Virtudes; Sánchez-Varo, Raquel María; Vizuete, Marisa; Dávila-Cansino, José Carlos; García-Verdugo, José Manuel; Vitorica, Javier; Gutiérrez-Pérez, Antonia[et al.] (Springer Nature, 2017)
Alzheimer's disease is a major neurodegenerative disorder that leads to severe cognitive deficits in the elderly population. Over the past two decades, multiple studies have focused on elucidating the causative factors ... -
Early neuronal loss and axonal/presynaptic damage is associated with accelerated amyloid-β accumulation in AβPP/PS1 Alzheimer's disease mice subiculum.
Trujillo-Estrada, Laura Isabel; Dávila-Cansino, José Carlos; Sánchez-Mejías, Elisabeth; Sánchez-Varo, Raquel María; Gómez-Arboledas, Ángela; Vizuete, Marisa; Vitorica, Javier; Gutiérrez-Pérez, Antonia[et al.] (IOS Press, 2014)
The progressive cognitive decline leading to dementia in Alzheimer’s disease (AD) patients is the consequence of a severe loss of synapses and neurons affecting particular cell subpopulations in selected brain areas, with ...