Listar Biología Celular, Genética y Fisiología - (BCGF) por título
Mostrando ítems 1-20 de 546
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18F-THK5351 PET imaging, neuropathology and clinical progression in a tau mouse model
(Alzheimer disease & Parkinson disease Conference 2021, 2021)Aims: Alzheimer’s disease (AD) and other associated dementias remain a consistent and unruly problem for the aging population and health. The neuropathology of AD is characterized by the extracellular deposition of ... -
3D Biomimetic Porous Titanium (Ti6Al4V ELI) Scaffolds for Large Bone Critical Defect Reconstruction: An Experimental Study in Sheep
Crovace, Alberto Maria; Lacitignola, Luca; Monopoli Forleo, Donato; Staffieri, Francesco; Francioso, Edda; Di Meo, Antonio; Becerra-Ratia, José
; Crovace, Antonio; Santos-Ruiz, Leonor[et al.] (MDPI, 2020-08-11)
The main goal in the treatment of large bone defects is to guarantee a rapid loading of the affected limb. In this paper, the authors proposed a new reconstructive technique that proved to be suitable to reach this purpose ... -
41 Cases of Treatment of Cranial Cruciate Ligament Rupture with Porous TTA: Three Years of Follow Up
Trisciuzzi, Rodrigo; Fracassi, Laura; Afonso Martín, Hernando; Monopoli Forleo, Donato; Amat, Daniel; Santos-Ruiz, Leonor; De Palma, Elena; Crovace, Alberto Maria[et al.] (MDPI, 2019-02-20)
Tibial Tuberosity Advancement (TTA) is a surgical technique based on a linear osteotomy that determines a cranial advancement of the tibial tuberosity in patients suffering from cranial cruciate ligament rupture (CCL). The ... -
A bacterial acetyltransferase targets the protein kinase ZIP1, a positive regulator of plant immunity
Rufián Plaza, José Sebastián; Rueda-Blanco, Javier; López-Márquez, Diego; Beuzón-López, Carmen del Rosario; Ruiz-Albert, Francisco Javier (2016-06-27)
Pseudomonas syringae is a model bacterial pathogen that penetrates the leaf to reach the plant apoplast, where it replicates causing disease. In order to do that, the pathogen must interfere and suppress a two-tiered plant ... -
A Bacterial Effector Protein Hijacks Plant Metabolism to Support Pathogen Nutrition.
(Cell Press, 2020)Many bacterial plant pathogens employ a type III secretion system to inject effector proteins within plant cells to suppress plant immunity. Whether and how effector proteins also co-opt plant metabolism to support extensive ... -
A collagen-targeted biomimetic RGD peptide to promote osteogenesis
Visser, Rick; Arrabal-García, Pilar María; Santos-Ruiz, Leonor; Fernández-Barranco, Raúl; Becerra-Ratia, José; Cifuentes-Rueda, Manuel[et al.] (MARY ANN LIEBERT, INC, 2014-01)
Osteogenesis is a complex, multifactorial process in which many different signals interact. The bone morphogenetic proteins (BMPs) are the most potent inducers of osteoblastic differentiation, although very high doses of ... -
A Comparative Transcriptome Analysis of Avocado Embryogenic Lines Susceptible or Resistant to Rosellinia necatrix Exudate.
Moreno-Pérez, Ana; Zumaquero, Adela; Martinez-Ferri, Elsa; López-Herrera, Carlos; Pliego-Alfaro, Fernando; Palomo-Ríos, Elena; Pliego-Prieto, Clara[et al.] (MDPI, 2023-05-12)
Avocado embryogenic cultures were selected for resistance to the culture filtrate (CF) of Rosellinia necatrix, the causal agent of White Root Rot disease. A resistant callus line was obtained through recurrent selections ... -
A Cysteine-Rich Protein Kinase Associates with a Membrane Immune Complex and the Cysteine Residues Are Required for Cell Death
(Oxford University Press, 2017-01)Membrane-localized proteins perceive and respond to biotic and abiotic stresses. We performed quantitative proteomics on plasma membrane-enriched samples from Arabidopsis (Arabidopsis thaliana) treated with bacterial ... -
A Defense Pathway Linking Plasma Membrane and Chloroplasts and Co-opted by Pathogens
(Elsevier, 2020-07)Chloroplasts are crucial players in the activation of defensive hormonal responses during plant-pathogen interactions. Here, we show that a plant virus-encoded protein re-localizes from the plasma membrane to chloroplasts ... -
A lysin motif effector subverts chitin-triggered immunity to facilitate arbuscular mycorrhizal symbiosis
Zeng, Tian; Rodríguez-Moreno, Luis Gabriel; Mansurkhodzaev, Artem; Wang, Peng; van den Berg, Willy; Gasciolli, Virginie; Cottaz, Sylvain; Fort, Sébastien; Thomma, Bart; Bono, Jean-Jaques; Bisseling, Ton; Limpens, Erik[et al.] (Wiley, 2020-01)
Arbuscular mycorrhizal (AM) fungi greatly improve mineral uptake by host plants in nutrient-depleted soil and can intracellularly colonize root cortex cells in the vast majority of higher plants. However, AM fungi possess ... -
A model of maxilla resection to test new hybrid implants:macroporous titanium and tissue engineering elements
Santos-Ruiz, Leonor; Monopoli, Donato; Yáñez Vilas, José Ignacio; Mentado, Belinda; Ruiz, F; Argárate, N; Granados, F; Arrabal-García, Pilar María; Belmonte, Rosa María; Becerra-Ratia, José[et al.] (2015-07-23)
Maxillary bone loss in commonly found in humans, due to bone ageing, tooth loos, periodontal disease and, more severely, to trauma, radiotherapy and tumor resection. Masillofacial reconstructive surgery is a still unmet ... -
A model of neuroinflammation and demyelination by intracerebroventricular injection of microbial neuraminidase
Fernández-Llebrez, Pedro; Granados-Durán, Pablo; Gómez-Roldán, María del Carmen; Cifuentes-Rueda, Manuel; Pérez-Martín, Margarita; Mateos-Grondona, Jesús; Rodriguez-de-Fonseca, Fernando; López-Ávalos, María Dolores[et al.] (2014-07-14)
Neuraminidase from Clostridium perfringens, which cleaves terminal sialic acid from carbohydrate chains, was injected in the lateral ventricle of rats. It diffused in the ipsilateral ventricle, the third ventricle, and ... -
A multidisciplinary approach to investigate plant-pathogen interactions
(Servicio de Publicaciones y Divulgación Científica, 2015)Pseudomonas syringae es una bacteria fitopatógena de gran interés tanto académico como económico, ya que afecta a gran variedad de cultivos hortícolas y ornamentales. Durante la interacción entre P. syringae y la planta ... -
A plant virus causes symptoms through the deployment of a host-mimicking protein domain to attract the insect vector.
Gao, Man; Aguilar Parras, Emmanuel; Garnelo-Gómez, Borja; Medina-Puche, Laura; Fan, Pengfei; Ontiveros, Irene; Pan, Shaojun; Tan, Huang; Von Roepenack-Lahaye, Edda; Chen, Na; Wang, Xiao-Wei; Baulcombe, David C.; Rodríguez-Bejarano, Eduardo; Díaz-Pendón, Juan Antonio; Furutani, Masahiko; Morita, Miyo Terao; Lozano-Durán, Rosa[et al.] (2023)
During compatible plant-virus interactions, viruses can interfere with the normal developmental program of their hosts, leading to the appearance of phenotypes that we usually identify as ‘’symptoms of infection’’ (leaf ... -
A secreted LysM effector protects fungal hyphae through chitin-dependent homodimer polymerization.
Sánchez-Vallet, Andrea; Tian, Hui; Rodríguez-Moreno, Luis Gabriel; Valkenburg, Dirk-Jan; Saleem-Batcha, Raspudin; Wawra, Stephan; Kombrink, Anja; Verhage, Leonie; De Jonge, Ronnie; Van Esse, Peter; Zuccaro, Alga; Croll, Daniel; Mesters, Jeroen; Thomma, Bart[et al.] (Public Library of Science, 2020-06-23)
Plants trigger immune responses upon recognition of fungal cell wall chitin, followed by the release of various antimicrobials, including chitinase enzymes that hydrolyze chitin. In turn, many fungal pathogens secrete LysM ... -
A sensitive method to quantify replicative forms of circular DNA viruses
(2013-12-13)Although real-time PCR diagnostic protocols for detection of geminivirusesare available, none of them are able to discriminate between the two strands generated during an infection: the viral strand (VS) that is encapsidated ... -
A synthetic collagen-binding arg-gly-asp (rgd) biomimetic peptide enhances bone cell differentiation
Visser, Rick; Arrabal-García, Pilar María; Santos-Ruiz, Leonor; Fernández-Barranco, Raúl; Cifuentes-Rueda, Manuel; Becerra-Ratia, José[et al.] (2013-11-27)
RGD (arginine-glycine-aspartic acid) peptides have shown some promising abilities to promote the attachment of cells to biomaterials and to direct their differentiation. However, anchoring these peptides to the biomaterial’s ... -
A virus-targeted plant receptor-like kinase promotes cell-to-cell spread of RNAi
Rosas Díaz; Dan, Zhanga; Fan, Pengfei; Liping, Wang; Xue, Ding; Yuli, Jiang; Jiménez-Góngora, Tamara; Medina-Puche, Laura; Xinyan, Zhao; Zhengyan, Feng; Guiping, Zhang; Xiaokun, Liuc; Rodríguez-Bejarano, Eduardo; Li, Tana; Heng, Zhang; Jian-Kang, Zhua; Weiman, Xinga; Faulkner, Christine; Shingo, Nagawa; Lozano Durán, Rosa[et al.] (PNAS, 2018-01-23)
RNA interference (RNAi) in plants can move from cell to cell, allowing for systemic spread of an antiviral immune response. How this cell-to-cell spread of silencing is regulated is currently unknown. Here, we describe ... -
Abeta from APP/PS1 Alzheimer mice hippocampus induced synaptic damage in vivo and in vitro
Sánchez-Varo, Raquel María; De Castro Carratalá, Vanessa; Trujillo-Estrada, Laura Isabel; Sánchez-Mejías, Elisabeth; Jiménez, Sebastián; Navarro, Victoria; Sanchez-Mico, Maria Virtudes; Gómez-Arboledas, Ángela; Vizuete, María Luisa; Dávila-Cansino, José Carlos; Gutiérrez-Pérez, Antonia[et al.] (2017-10-02)
We aim to investigate the effects of Abeta from young APP/PS1 mouse model of Alzheimer`s disease (AD) on the synaptic integrity, as the loss of synapses strongly correlates with cognitive deficits in patients. Plaque-associated ... -
Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus.
Sánchez-Varo, Raquel María; Trujillo-Estrada, Laura Isabel; Sánchez-Mejías, Elisabeth; Torres, Manuel; Baglietto-Vargas, David; Moreno-González, Inés; De Castro, Vanessa; Jiménez, Sebastián; Ruano, Diego; Vizuete, Marisa; Dávila-Cansino, José Carlos; García-Verdugo, José Manuel; Jiménez-Lara, Antonio Jesús; Vitorica, Javier; Gutiérrez-Pérez, Antonia[et al.] (Springer Nature, 2012)
Dystrophic neurites associated with amyloid plaques precede neuronal death and manifest early in Alzheimer’s disease (AD). In this work we have characterized the plaque-associated neuritic pathology in the hippocampus ...