Biología Celular, Genética y Fisiología - (BCGF)
Estas son las colecciones en las que puede catalogar la producción investigadora del departamento Biología Celular, Genética y Fisiología. Si considera que ninguna de estas se ajusta a su material pida una nueva colección en la sección de sugerencias.
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The Immune-associated nucleotide-binding 9 Protein Is a Regulator of Basal Immunity in Arabidopsis thaliana.
(American Phytopathological Society, 2018)A robust regulation of plant immune responses requires a multitude of positive and negative regulators that act in concert. The immune-associated nucleotide-binding (IAN) gene family members are associated with immunity ... -
Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition.
(Elsevier, 2013-10-22)Recent studies on tauopathy animal models suggest that the concomitant expression of the endogenous murine tau delays the pathological accumulation of human tau, and interferes with the disease progression. To elucidate ... -
Glutaminase activity is confined to the mantle of the islets of Langerhans.
Montero, Fernando; Baglietto-Vargas, David; Moreno-González, Inés; López-Téllez, Juan Félix; Cuesta Muñoz, Antonio L.; Gutiérrez-Pérez, Antonia
; Aledo-Ramos, Juan Carlos[et al.] (Elsevier, 2007)
Glutamatergic signalling plays an important role in the coordination of hormone secretion from the endocrine pancreas. Thus, glutamate production must be a process exquisitely regulated to ensure a proper transmitter ... -
Role of Layer 6 of V2 Visual Cortex in Object-Recognition Memory.
López-Aranda, Manuel Francisco; López-Téllez, Juan Félix; Navarro-Lobato, Irene; Masmudi-Martín, Mariam; Gutiérrez-Pérez, Antonia; Khan, Zafaruddin[et al.] (AAAS, 2009-07-03)
Cellular responses in the V2 secondary visual cortex to simple as well as complex visual stimuli have been well studied. However, the role of area V2 in visual memory remains unexplored. We found that layer 6 neurons of ... -
Basophil activation test positivity decreases with time in immediate allergic reactions to proton pump inhibitors
Fernández-Santamaría, Rubén; Salas, Maria; Ariza Veguillas, Adriana; Jiménez, María A.; González-Mendiola, María R.; Sánchez, María L.; Boteanu, Cosmin; Mayorga Mayorga, Cristobalina; Fernández-Duarte, Tahía Diana; Torres, María José; Laguna, José J.[et al.] (Wiley, 2024-11-27)
Omeprazole is a widely prescribed proton pump inhibitor [1], with 1%–3% of adverse reactions being reported. Up to 86% of these reactions are IgE mediated [2] and half of them anaphylaxis [1]. An accurate diagnosis is ... -
Msx1-deficient mice fail to form prosomere 1 derivatives, subcommissural organ, and posterior commissure and develop hydrocephalus
Fernández-Llebrez, Pedro; Mateos-Grondona, Jesús; Pérez-Rodríguez, Juan; López-Aranda, Manuel Francisco; Estivill-Torrús, Guillermo; Llebrez Zayas, Pedro; Soriano, E.; Ramos, C.; Lallemand, Y.; Bach, A.; Robert, B.[et al.] (Oxford University Press, 2004-06)
Msx1 is a regulatory gene involved in epithelio-mesenchymal interactions in limb formation and organogenesis. In the embryonic CNS, the Msx1 gene is expressed along the dorsal midline. Msx1 mutant mice have been obtained ... -
Molecular and cellular characterization of the age-related neuroinflammatory processes occurring in normal rat hippocampus: potential relation with the loss of somatostatin GABAergic neurons.
Gavilán, M. Paz; Revilla, Elisa; Pintado, Cristina; Castaño, Angélica; Vizuete, María Luisa; Moreno-González, Inés; Baglietto-Vargas, David; Sánchez-Varo, Raquel María; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia; Ruano, Diego[et al.] (Wiley, 2007-06-29)
Increased neuroinflammatory reaction is frequently observed during normal brain aging. However, a direct link between neuroinflammation and neurodegeneration during aging has not yet been clearly shown. Here, we have ... -
Segregation of two glutaminase isoforms in islets of Langerhans.
Baglietto-Vargas, David; López-Téllez, Juan Félix; Moreno-González, Inés; Gutiérrez-Pérez, Antonia; Aledo-Ramos, Juan Carlos (Portland Press, 2004-01-31)
Despite the importance of glutamatergic signalling in the co-ordination of hormone secretion, the identity of the enzyme for the production of glutamate in β-cells is still unresolved. We have found that the endocrine ... -
Early neuropathology of somatostatin/NPY GABAergic cells in the hippocampus of a PS1xAPP transgenic model of Alzheimer's disease.
Ramos, Blanca; Baglietto-Vargas, David; del Rio, Juan Carlos; Moreno-González, Inés; Santa-Maria, Consuelo; Jiménez, Sebastián; Caballero, Cristina; López-Téllez, Juan Félix; Khan, Zafar U.; Ruano, Diego; Gutiérrez-Pérez, Antonia; Vitorica, Javier[et al.] (Elsevier, 2006-11)
At advanced stages, Alzheimer's disease (AD) is characterized by an extensive neuronal loss. However, the early neurodegenerative deficiencies have not been yet identified. Here we report an extensive, selective and early ... -
Reactive astrocyte nomenclature, definitions, and future directions.
Escartin, Carole; Galea, Elena; Lakatos, András; O`Callaghan, James P.; Petzold, Gabor C.; Serrano-Pozo, Alberto; Steinhäuser, Christian; Volterra, Andrea; Carmignoto, Giorgo; Agarwal, Amit; Allen, Nicola J.; Araque, Alfonso; Barbeito, Luis; Barzilai, Ari; Bergles, Dwight E.; Bonvento, Gilles; Butt, Arthur M.; Chen, Wei-Ting; Cohen-Salmon, Martine; Cunningham, Colm; Deneen, Benjamin; De Strooper, Bart; Diaz-Castillo, Blanca; Farina, Cinthia; Freeman, Marc; Gallo, Vittorio; Goldman, James E.; Goldman, Steven A.; Götz, Magdalena; Gutiérrez-Pérez, Antonia; Haydon, Philip G.; Heiland, Dieter H.; Hol, Elly M.; Holt, Matthew G.; Lino, Masamitsu; Kastanenka, Ksenia V.; Kettenmann, Helmut; Khakh, Baljit S.; Koizumi, Schuichi; Lee, Justin C.; Liddelow, Shane A.; MacVicar, Brian A.; Magistretti, Pierre; Messing, Albee; Mishra, Anusha; Molofsky, Anna V.; Mural, Keith K.; Norris, Christopher M.; Okada, Seiji; Oliet, Stéphane H.R.; Oliveira, Joao F.; Panatier, Aude; Parpura, Vladimir; Pekna, Marcela; Pekny, Milos; Pellerin, Luc; Perea, Gertrudis; Perez-Nievas, Beatriz G.; Pfrieger, Frank W.; Poskanzer, Kira E.; Quintana, Francisco J.; Ransohoff, Richard M.; Riquelme-Perez, Miriam; Robel, Stefanie; Rose, Christine R.; Rothstein, Jeffrey D.; Rouach, Nathalie; Rowitch, David H.; Semyanov, Alexey; Sirko, Swetlana; Sontheimer, Harald; Swanson, Raymond A.; Vitorica, Javier; Wanner, Ina-Beate; Wood, Levi B.; Wu, Jiagin; Zheng, Binhai; Zimmer, Eduardo R.; Zorec, Robert; Sofroniew, Michael; Verkhratsky, Alexei[et al.] (Springer Nature, 2021-02-15)
Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional remodeling in response to injury, disease, or infection of the CNS. Although this remodeling was first described over a century ago, ... -
Short-term modern life-like stress exacerbates Aβ-pathology and synapse loss in 3xTg-AD mice
(Wiley, 2015-09)Alzheimer's disease (AD) is a progressive neurological disorder that impairs memory and other cognitive functions in the elderly. The social and financial impacts of AD are overwhelming and are escalating exponentially as ... -
Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology
(Elsevier, 2013-09-01)Background Increased circulating glucocorticoids are features of both aging and Alzheimer’s disease (AD), and increased glucocorticoids accelerate the accumulation of AD pathologies. Here, we analyzed the effects of the ... -
A dynamic expression pattern of sGalpha(i2) protein during early period of postnatal rat brain development.
López-Aranda, Manuel Francisco; López-Téllez, Juan Félix; Blanco-Calvo, Eduardo; Masmudi-Martín, Mariam; Navarro-Lobato, Irene; Khan, Zafaruddin[et al.] (Elsevier, 2008-10-07)
The function of sG alpha i2 protein in central nervous system is not well understood. Therefore to explore the possible role of this protein in postnatal brain development, we have analyzed the protein expression pattern ... -
Basal Sodium-Dependent Vitamin C Transporter 2 polarization in choroid plexus explant cells in normal or scorbutic conditions
Ulloa, Viviana; Saldivia, Natalia; Ferrada, Luciano; Salazar, Katherine; Martínez, Fernando; Silva-Álvarez, Carmen; Magdalena, Rocío; Oviedo, María José; Montecinos, Hernán; Torres-Vergara, Pablo; Cifuentes-Rueda, Manuel; Nualart, Francisco[et al.] (Springer Nature, 2019-10)
Vitamin C is incorporated into the cerebrospinal fluid (CSF) through choroid plexus cells. While the transfer of vitamin C from the blood to the brain has been studied functionally, the vitamin C transporter, SVCT2, has ... -
Dehydroascorbic acid, the oxidized form of vitamin C, improves renal histology and function in old mice
Forman, Katherine; Martínez, Fernando; Cifuentes-Rueda, Manuel; Fernández, Marcos; Bertinar, Romina; Torres, Pablo; Salazar, Katherine; Godoy, Alejandro; Nualart, Francisco[et al.] (Wiley, 2020-12)
Oxidative stress and inflammation are crucial factors that increase with age. In the progression of multiple age-related diseases, antioxidants and bioactive compounds have been recognized as useful antiaging agents. ... -
Biallelic mutations in LAMA5 disrupts a skeletal noncanonical focal adhesion pathway and produces a distinct bent bone dysplasia.
(Elsevier, 2020-11-23)Background Beyond its structural role in the skeleton, the extracellular matrix (ECM), particularly basement membrane proteins, facilitates communication with intracellular signaling pathways and cell to cell interactions ... -
Dominant-negative SOX9 mutations in campomelic dysplasia.
(Wiley, 2019-08-07)Campomelic dysplasia (CD) is an autosomal dominant, perinatal lethal skeletaldysplasia characterized by a small chest and short long bones with bowing of thelower extremities. CD is the result of heterozygosity for mutations ... -
Ascorbic acid and its transporter SVCT2, affect radial glia cells differentiation in postnatal stages
Saldivia, Natalia; Salazar, Katterine; Cifuentes-Rueda, Manuel; Espinoza, F; Harrison, FE; Nualart, Francisco[et al.] (Wiley, 2024-04)
Radial glia (RG) cells generate neurons and glial cells that make up the cerebral cortex. Both in rodents and humans, these stem cells remain for a specific time after birth, named late radial glia (lRG). The knowledge of ... -
Hyperglycemia increases SCO-spondin and Wnt5a secretion into the cerebrospinal fluid to regulate ependymal cell beating and glucose sensing
Nualart, Francisco; Cifuentes-Rueda, Manuel; Ramírez, Eder; Martínez, Fernando; Barahona, M José; Ferrada, Luciano; Saldivia, N; Borgonzone, Ernesto R; Thorens, B; Salazar, Katterine[et al.] (Public Library of Science, 2023-09)
Hyperglycemia increases glucose concentrations in the cerebrospinal fluid (CSF), activating glucose-sensing mechanisms and feeding behavior in the hypothalamus. Here, we discuss how hyperglycemia temporarily modifies ... -
Is IIIG9 a New Protein with Exclusive Ciliary Function? Analysis of Its Potential Role in Cancer and Other Pathologies
Oviedo, MJ; Ramírez, E; Cifuentes-Rueda, Manuel; Farkas, Carlos; Mella, Andy; Bertinat, Romina; Gajardo, Roberto; Ferrada, Luciano; Jara, Nery; De lima, Isabelle; Martínez, Fernando; Nualart, Francisco; Salazar, Katerine[et al.] (MDPI, 2022-10)
The identification of new proteins that regulate the function of one of the main cellular phosphatases, protein phosphatase 1 (PP1), is essential to find possible pharmacological targets to alter phosphatase function in ...