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dc.contributor.authorÁvila-Gámiz, Fabiola
dc.contributor.authorMañas-Padilla, María del Carmen
dc.contributor.authorLadrón de Guevara-Miranda, David
dc.contributor.authorGil Rodríguez, Sara
dc.contributor.authorRodriguez-de-Fonseca, Fernando
dc.contributor.authorCastilla-Ortega, María Estela 
dc.contributor.authorSantín-Núñez, Luis Javier 
dc.date.accessioned2019-10-01T10:34:16Z
dc.date.available2019-10-01T10:34:16Z
dc.date.created2019
dc.date.issued2019-10-01
dc.identifier.urihttps://hdl.handle.net/10630/18501
dc.description.abstractAims:Modulation of hippocampal memories related with cocaine addiction such as cocaine-context associations could have important clinical implications. It has been asserted that learning-related experiences promote hippocampal plasticity enhancing adult hippocampal neurogenesis (AHN). Here we aimed to evaluate (1) the stimulation of AHN using a spatial learning task dependent on the hippocampus and (2) whether spatial learning reduces the long-term maintenance and reinstatement of previously acquired cocaine-associated contextual memories. Methods: Male C57BL/6J mice were first submitted to a cocaine induced conditioned place preference paradigm (CPP). Then, bromodeoxyuridine (BrdU) was administered in order to label newborn neurons. One week after the last BrdU injection, a group of mice were trained in a spatial learning task using the Morris water maze while control animals received a non-hippocampal training or stayed undisturbed in their home-cages. Twenty seven days after conditioning, mice were tested for CPP retention and extinction. Finally, a cocaine priming-induced reinstatement of drug seeking was performed. Results: Animals trained in the spatial learning task exhibited a lower long-term CPP retention memory. In addition, cocaine-induced CPP reinstatement was attenuated in trained animals. Immunohistochemistry showed an increment in the BrdU+ cells in the hippocampus of trained animals in contrast with control animals. Conclusions: Spatial memory training using the Morris water maze constitutes a tool to promote the survival of newborn neurons in the hippocampus. Furthermore, stimulation of AHN might be a neurobiological mechanism by which spatial learning reduces the long-term maintenance of previous cocaine-context associative memory. Supported by PSI2017-82604 (MICINN Spain); PSI2015-73156-JIN. Universidad de Málaga.en_US
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectToxicomanía - Tratamientoen_US
dc.subjectCocainaen_US
dc.subjectHipocampo (Cerebro)en_US
dc.subjectExperimentación animalen_US
dc.subject.otherAdult hippocampal neurogenesisen_US
dc.subject.otherSpatial memoryen_US
dc.subject.otherCocaine-context associationsen_US
dc.titleEnhancement of adult hippocampal neurogenesis by spatial memory training and its effect on the maintenance of cocaine-contextual memoryen_US
dc.typeinfo:eu-repo/semantics/conferenceObjecten_US
dc.centroFacultad de Psicología y Logopediaen_US
dc.relation.eventtitle48th Meeting of the European Brain and Behaviour Societyen_US
dc.relation.eventplacePraga, República Checaen_US
dc.relation.eventdate21/09/2019en_US


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