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dc.contributor.authorCheng-Sánchez, Iván
dc.contributor.authorCarrillo Fernández, Paloma
dc.contributor.authorGarcía-Ruiz, Cristina
dc.contributor.authorMartínez-Póveda, Beatriz Amparo 
dc.contributor.authorRodríguez-Quesada, Ana María 
dc.contributor.authorMedina-Torres, Miguel Ángel 
dc.contributor.authorSarabia-García, Francisco Ramón 
dc.date.accessioned2019-09-18T07:27:09Z
dc.date.available2019-09-18T07:27:09Z
dc.date.created2019
dc.date.issued2019-09-18
dc.identifier.urihttps://hdl.handle.net/10630/18378
dc.description.abstract(-)-Depudecin (1) (Figure 1), isolated from the culture broths of the fungus Alternaria brassicicola,1 and later, from the weed pathogen Nimbya scirpicola,2 has been identified as a selective inhibitor of histone deacetylases (HDAC) with an IC50 in the low M range.3 In contrast to representative HDAC inhibitors, depudecin represents a unique inhibitor of these enzymes by virtue of its molecular structure, featuring the presence of two oxirane rings separated by a trans double bond. Originally discovered as part of a biological screening directed towards the identification of antitumour agents with detransforming activity,4 depudecin was identified as a bioactive metabolite capable of reverting the transformed morphology of tumor cells. This biological activity elicited a great biomedical and biological interest by virtue of its potential as an antitumor agent as well as for further understanding the biological roles of HDACs. Depudecin induced not only morphological changes but also cell cycle arrest and cellular differentiation,5 and also exhibited remarkable anti-angiogenesis activity.6 Prompted by its striking biological properties and enticing structure, we decided to initiate a research program directed towards the synthesis of natural depudecin. Our synthetic plan has recently culminated with linear and convergent total syntheses.7en_US
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Techen_US
dc.language.isospaen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTumores - Crecimientoen_US
dc.subjectCáncer - Tratamientoen_US
dc.subject.otherDepudecinen_US
dc.subject.otherNatural producten_US
dc.subject.otherStereoselective synthesisen_US
dc.subject.otherAnaloguesen_US
dc.subject.otherAntitumoralen_US
dc.titleSynthesis and Biological Evaluation of Depudecin Analoguesen_US
dc.typeinfo:eu-repo/semantics/conferenceObjecten_US
dc.centroFacultad de Cienciasen_US
dc.relation.eventtitleVIII International Symposium on Advances in Synthetic and Medicinal Chemistryen_US
dc.relation.eventplaceAtenas, Greciaen_US
dc.relation.eventdateSeptiembre 2019en_US


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