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dc.contributor.authorNieto-Quero, Andrea
dc.contributor.authorGómez-Salas, Francisco Javier
dc.contributor.authorMoreno-Fernández, Román D.
dc.contributor.authorRosell-del-Valle, Cristina
dc.contributor.authorPérez-Martín, Margarita 
dc.contributor.authorCifuentes-Rueda, Manuel 
dc.contributor.authorGarcía-Fernández, María Inmaculada 
dc.contributor.authorChun, Jerold
dc.contributor.authorEstivill-Torrús, Guillermo
dc.contributor.authorRodriguez-de-Fonseca, Fernando
dc.contributor.authorSantín-Núñez, Luis Javier 
dc.contributor.authorPedraza-Benítez, María del Carmen 
dc.date.accessioned2018-07-17T07:15:45Z
dc.date.available2018-07-17T07:15:45Z
dc.date.created2018-07-08
dc.date.issued2018-07-17
dc.identifier.urihttps://hdl.handle.net/10630/16285
dc.description.abstractPrevalence of stress-related disorders, such as depression, is raising in modern societies. Indeed, current neurobiological research aims to elucidate the link between deregulation of the hypothalamic-pituitary-adrenal (HPA) axis among vulnerable individuals and the onset of depressive symptoms, such as social withdrawal. Herein, we seek to determine the role of LPA1 receptor in social behaviour and the performance of maLPA1-null mice, a model of anxious depression, in the dexamethasone (DEX) suppression test. For that purpose, we used the three-chamber test for social preference. Also, we administered vehicle or DEX 0.1mg/kg to wild-type (WT) mice and maLPA1-null mice, analysed corticosterone (CORT) response by ELISA method and determine glucocorticoid receptor (GR) expression and serum/glucocorticoid regulated kinase 1 (SGK1) in the hippocampus by Western-Blot analysis. We found that maLPA1-null mice lack preference for the social chamber as compared to WT animals. Additionally, mice lacking the LPA1 receptor did not suppress CORT after DEX treatment and increased significantly hippocampal SGK1 expression despite unaltered GR protein levels. These results provide further insight on the role of LPA1 receptors in depressive-like behavior and the pathological intracellular signals involved in stress regulation.en_US
dc.description.sponsorshipAndalusian Regional Ministries of Economy, Innovation, Science and Employment (SEJ1863 to CP and CTS-643 to GE-T) and of Health (Nicolas Monardes Programme to GE-T). Spanish Ministry of Economy and Competitiveness (PSI2013-44901-P to LJS and CP; and co-financed with Funds of the European Commission “FEDER” PSI2017-83408-P to CP). Author AN-Q and RDM-F hold Grants of the Spanish Ministry of Education, Culture and Sports (FPU 16/05308; FPU14/01610, respectively). Author FJG-S held a Grant of the First Research and Transfer Plan of the University of Malaga. University of Malaga, Campus de Excelencia Internacional Andalucía Tech, and I Plan Propio de Investigación y Transferencia of the University of Malaga.en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNeurociencias - Congresosen_US
dc.subject.otherLPA1 receptoren_US
dc.subject.otherHypothalamic-pituitary-adrenal (HPA) axisen_US
dc.subject.otherGlucocorticoid receptoren_US
dc.subject.otherCorticosteroneen_US
dc.subject.otherDepressionen_US
dc.titleSocial avoidance and altered stress axis in a mouse model of anxious depressionen_US
dc.typeinfo:eu-repo/semantics/conferenceObjecten_US
dc.centroFacultad de Psicología y Logopediaen_US
dc.relation.eventtitle11th FENS FORUM OF NEUROSCIENCEen_US
dc.relation.eventplaceBERLÍN (ALEMANIA)en_US
dc.relation.eventdate07/07/2018-11/07/2018en_US


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