JavaScript is disabled for your browser. Some features of this site may not work without it.

    Listar

    Todo RIUMAComunidades & ColeccionesPor fecha de publicaciónAutoresTítulosMateriasTipo de publicaciónCentrosDepartamentos/InstitutosEditoresEsta colecciónPor fecha de publicaciónAutoresTítulosMateriasTipo de publicaciónCentrosDepartamentos/InstitutosEditores

    Mi cuenta

    AccederRegistro

    Estadísticas

    Ver Estadísticas de uso

    DE INTERÉS

    Datos de investigaciónReglamento de ciencia abierta de la UMAPolítica de RIUMAPolitica de datos de investigación en RIUMAOpen Policy Finder (antes Sherpa-Romeo)Dulcinea
    Preguntas frecuentesManual de usoContacto/Sugerencias
    Ver ítem 
    •   RIUMA Principal
    • Investigación
    • Ponencias, Comunicaciones a congresos y Pósteres
    • Ver ítem
    •   RIUMA Principal
    • Investigación
    • Ponencias, Comunicaciones a congresos y Pósteres
    • Ver ítem

    Are amyloids infectious? Prions and prion-like proteins: myths and facts

    • Autor
      Morales Loyola, Rodrigo
    • Fecha
      2018-06-01
    • Palabras clave
      Alzheimer, Enfermedad de
    • Resumen
      Transmissible Spongiform Encephalopathies (TSEs) or prion diseases are a group of fatal neurodegenerative disorders affecting mammals. Albeit their low incidence in humans, prion diseases are a subject of passionate research due to their unorthodox mechanisms of transmission mediated by misfolded proteins, and the zoonotic potential of Bovine Spongiform Encephalopathy (BSE or “mad cow” disease). Importantly, prion diseases in deer and sheep can be prevalent and persistent, raising important concerns in terms of public health due to their uncontrolled spread and possible transmission to humans. Importantly, the accumulation of misfolded protein aggregates is not an exclusive feature of TSEs, but also present in several other pathological conditions including Alzheimer’s Disease (AD), Parkinson´s disease, type-2 diabetes, and others. Recent reports suggest that the spread of misfolded proteins and further pathological features in these diseases operates in a similar manner as seen for infectious prions. This has opened controversial and prolific lines of investigation that are currently being explored by several research groups around the world. In this presentation, I will focus on recent advances for prion detection in Chronic Wasting Disease (CWD), a TSE of cervids. In addition, mechanistic aspects of CWD transmission will be discussed, including horizontal and environmental transmission, role of prion protein polymorphisms in prion strain variation, and others. The second part of my talk will center on our research exploring whether features that define prions as infectious agent exist on AD’s amyloid-β. Specifically, the possibility of inter-individual transmission, presence of conformational strain variation, etc. on misfolded amyloid-β will be discussed. My aim in this talk is to highlight the common mechanisms of spread for prions and amyloid-β, and suggest common strategies for early diagnosis based in the prion-principle.
    • URI
      https://hdl.handle.net/10630/15891
    • Compartir
      RefworksMendeley
    Mostrar el registro completo del ítem
    Ficheros
    Abstract Conferencia Malaga 2018 RodrigoMorales.pdf (324.9Kb)
    Cartel Conferencia Rodrigo Morales.pdf (73.02Kb)
    Colecciones
    • Ponencias, Comunicaciones a congresos y Pósteres

    Estadísticas

    Buscar en Dimension
    REPOSITORIO INSTITUCIONAL UNIVERSIDAD DE MÁLAGA
    REPOSITORIO INSTITUCIONAL UNIVERSIDAD DE MÁLAGA
     

     

    REPOSITORIO INSTITUCIONAL UNIVERSIDAD DE MÁLAGA
    REPOSITORIO INSTITUCIONAL UNIVERSIDAD DE MÁLAGA