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dc.contributor.authorPiedra-Aguilera, Álvaro
dc.contributor.authorJiao, Chen
dc.contributor.authorEsteve-Codina, Anna
dc.contributor.authorAbad, Marc
dc.contributor.authorPérez-Luna, Ana Isabel 
dc.contributor.authorVillanueva-Montiel, Francisco
dc.contributor.authorDíaz-Pendón, Juan Antonio
dc.contributor.authorFei, Zhangjun
dc.contributor.authorRodríguez-Bejarano, Eduardo 
dc.contributor.authorCastillo-Garriga, Araceli 
dc.date.accessioned2018-01-08T10:49:48Z
dc.date.available2018-01-08T10:49:48Z
dc.date.created2017
dc.date.issued2018-01-08
dc.identifier.urihttps://hdl.handle.net/10630/14985
dc.description.abstractGeminiviruses constitute the largest family of plant-infecting viruses with small, single- stranded DNA genomes that replicate through double-stranded DNA intermediates. Because of their limited coding capacity, geminiviruses use plant nuclear machiney to amplify their genomes, which are packaged into nucleosomes forming chromatin as multiple circular minichromosomes. Thus, viral minichromosomes must encounter the nuclear pathways that regulate host gene expression and chromatin states. DNA methylation and post-transcriptional gene silencing play critical roles in controlling infection of geminiviruses and this pathogen can counteract these host defense mechanisms and promote its infectivity. To better understand this virus-host interaction at a genetic and epigenetic level we have analysed the transcriptome, sRNA profile and methylome of tomato plants infected with the geminivirus, TYLCV (Tomato yellow leaf curl virus). Total RNA and DNA was extracted from tomato–infected plants (three biological replicates) and analysed at 2, 7, 14 and 21 days pots-infection (dpi). Analysis of the changes in host transcription during the infection and its correlation with changes in sRNA profiles and DNA methylation will be discussed/shown. This work represents the first comprehensive study of the genetic and epigenetics interactions established during a geminivirus infection in its natural host.en_US
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectVirus fitopatógenosen_US
dc.subject.otherGeminivirusen_US
dc.subject.otherTranscriptomaen_US
dc.subject.otherMetilomaen_US
dc.subject.othersiRNAen_US
dc.subject.otherTYLCVen_US
dc.titleIntregrated transcriptome, methylome and smallRNA profile analysis of a geminivirus infectionen_US
dc.typeinfo:eu-repo/semantics/conferenceObjecten_US
dc.centroFacultad de Cienciasen_US
dc.relation.eventtitleEpigenetic mechanisms in health and disease. Barcelona conference on epigenetics and canceren_US
dc.relation.eventplaceBarcelonaen_US
dc.relation.eventdate25-10-2017en_US


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