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dc.contributor.authorJiménez-Lara, Antonio Jesús 
dc.contributor.authorOjeda-Pérez, Betsaida
dc.contributor.authorGarcía-Bonilla, María
dc.contributor.authorRuz-Maldonado, Inmaculada
dc.contributor.authorMateos-Grondona, Jesús 
dc.contributor.authorRodríguez-Pérez, Luis Manuel 
dc.contributor.authorPáez-González, Patricia 
dc.date.accessioned2017-06-28T10:50:47Z
dc.date.available2017-06-28T10:50:47Z
dc.date.created2017
dc.date.issued2017-06-28
dc.identifier.urihttp://hdl.handle.net/10630/14061
dc.descriptionComunicación oral. El resumen no se publica por deseo de los autoreses_ES
dc.description.abstractNG2 cells are considered oligodendrocyte precursor cells (OPC). In pathological conditions, NG2 cells contribute to generate oligodendrocytes and reactive astrocytes. This study has been designed to uncover the role of NG2 cells in congenital hydrocephalus using the hyh mouse model. Materials and methods Brain sections and whole mount preparations were obtained from embryos and postnatal hyh and control mice. NG2 positive (NG2+) cells were co-labelled with different IHC markers to deepest identification. Additionally, trying to understand reproducibility of our results in different neurodegenerative conditions, same NG2 identification approach was performed using ventricular walls explants from control mice after mechanical induction of astrocyte reaction. Results A higher number of NG2+ cells were found in the hyh mice compared to the control mice. In addition, NG2+ cells in the hyh mice showed a higher NG2 antigen content compared to the control mice. In the hyh mouse, colocalization results showed that most of NG2+ cells were identified as OPC cells and pericytes, but never as reactive astrocytes o microglial cells. However, in the same approach performed in neurodegenerative conditions, NG2+ cells were mostly identified as reactive astrocytes. Conclusions NG2 progenitors appear to be affected in hyh mutant mice giving rise to a different NG2+population which role in hydrocephalus is still unkown.es_ES
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectHidrocefaliaes_ES
dc.subject.otherGlíaes_ES
dc.titleNG2 cells in an animal model of congenital hydrocephaluses_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Cienciases_ES
dc.relation.eventtitleICCS and SRHSB Joint Conferencees_ES
dc.relation.eventplaceSan Luis, EE.UU.es_ES
dc.relation.eventdate24/06/2017es_ES
dc.rights.ccby-nc-nd


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