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dc.contributor.authorMacho, Alberto P.
dc.date.accessioned2017-05-08T09:29:03Z
dc.date.available2017-05-08T09:29:03Z
dc.date.created2017
dc.date.issued2017-05-08
dc.identifier.urihttp://hdl.handle.net/10630/13603
dc.descriptionSeminario Docentees_ES
dc.description.abstractDeciphering the interaction between plants and the bacterial pathogen Ralstonia solanacearum Alberto P. Macho Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences; Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 201602, China. Most bacterial plant pathogens employ a type-III secretion system to inject type-III effector (T3E) proteins directly inside plant cells. The complex infection process of Ralstonia solanacearum is supported by a large number of T3Es, although the function of most of them is still unknown. In order to understand the plant infection by R. solanacearum, we are performing screens aimed at identifying T3Es that target diverse plant functions, including immunity, responses to other environmental cues, and development. Following this strategy, we have found that R. solanacearum employs different T3Es to manipulate the immune responses to bacterial elicitors and hormone signalling. One of these T3E, RipAY, is a strong suppressor of immune responses. Transient expression of RipAY in Nicotiana benthamiana leaves severely compromises the plant response to bacterial elicitors and to exogenous treatment with salicylic acid. Biochemical analysis shows that RipAY associates with several different cytosolic thioredoxins in plant cells. Additionally, RipAY has a domain with predicted gamma-glutamyl cyclotransferase activity, usually involved in the degradation of glutathione, a major determinant of cellular redox state. Consistent with this, we found that RipAY degrades glutathione in plant cells, and this biochemical activity is required for the suppression of immunity. Our results suggest that R. solanacearum employs RipAY to manipulate the redox regulation of host cells, displaying a novel virulence strategy that has a severe impact on immune responses.es_ES
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectBacterias fitopatógenases_ES
dc.subject.otherPlant Pathogenes_ES
dc.titleDeciphering the interaction between plants and the bacterial pathogen Ralstonia solanacearumes_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Cienciases_ES
dc.relation.eventtitleSeminario Máster en Biotecnología Avanzadaes_ES
dc.relation.eventplaceSO6es_ES
dc.relation.eventdateAbril 2017es_ES
dc.rights.ccby-nc-nd


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