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dc.contributor.authorSantín-Núñez, Luis Javier 
dc.contributor.authorZambrana-Infantes, Emma
dc.contributor.authorGaleano, Pablo
dc.contributor.authorRosell-del-Valle, Cristina
dc.contributor.authorLadrón de Guevara-Miranda, David
dc.contributor.authorCastilla-Ortega, María Estela 
dc.contributor.authorRodriguez-de-Fonseca, Fernando
dc.contributor.authorBlanco-Calvo, Eduardo 
dc.date.accessioned2016-07-13T06:42:46Z
dc.date.available2016-07-13T06:42:46Z
dc.date.created2016
dc.date.issued2016-07-13
dc.identifier.urihttp://hdl.handle.net/10630/11824
dc.description.abstractAims. Cocaine addiction is a chronically relapsing disorder characterized by the compulsion to seek and take the drug. Previous investigations have demonstrated that several drugs of abuse, as cocaine, can alter the levels of lipid-based signalling molecules such as the N-acylethanolamines (NAEs). In addition, NAEs levels in the brain are sensitive to cocaine self-administration and extinction training. In this context, this study aimed to investigate the effect of repeated and acute palmitoylethanolamide (PEA), an endogenous NAE, on the behavioural effects of cocaine using mouse models of conditioned reward and psychomotor activation. Methods. Using male C57BL/6J mice, the ability of repeated PEA injections (1 or 10 mg/kg i.p) to modulate the development of a conditioned place preference (CPP) and behavioural sensitization (BS) induced by cocaine (20 mg/kg i.p.) was evaluated. In addition, the expression of cocaine-induced CPP and BS after acute PEA administration was also studied. Results. PEA (1 and 10 mg/kg i.p) significantly reduced the development of cocaine-induced BS, but did not modify the acquisition of cocaine-induced CPP. Furthermore, both doses of PEA were able to reduce the expression of BS and CPP. Conclusions. Altogether, these findings show that exogenous administration of PEA attenuated psychomotor activation and impaired the expression of CPP induced by cocaine. Our results may be relevant in order to understand the role of NAEs in the development and treatment of cocaine addiction.es_ES
dc.description.sponsorshipUniversidad de Málaga, Campus de Excelencia Internacional Andalucía Tech. PSI2013-44901-P, AP2010-2044, FPU13/04819, CD12/00455es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectCocaínaes_ES
dc.subjectToxicomaníaes_ES
dc.subject.otherCocainees_ES
dc.subject.otherpalmitoylethanolamidees_ES
dc.subject.otherbehavioural sensitizationes_ES
dc.subject.otherCPPes_ES
dc.titleEffects of palmitoylethanolamide in cocaine-induced behaviourses_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Psicología y Logopediaes_ES
dc.relation.eventtitle10th FENS Forum of Neuroscience 2016es_ES
dc.relation.eventplaceCopenhague (Denmark)es_ES
dc.relation.eventdatejulio, 2016es_ES
dc.rights.ccby-nc-nd


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