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dc.contributor.authorLadrón de Guevara-Miranda, David
dc.contributor.authorPavón-Morón, Francisco Javier
dc.contributor.authorSerrano, Antonia
dc.contributor.authorRivera, Patricia
dc.contributor.authorEstivill-Torrús, Guillermo
dc.contributor.authorSuárez-Pérez, Juan 
dc.contributor.authorRodriguez-de-Fonseca, Fernando
dc.contributor.authorSantín-Núñez, Luis Javier 
dc.contributor.authorCastilla-Ortega, María Estela 
dc.date.accessioned2016-07-13T06:35:03Z
dc.date.available2016-07-13T06:35:03Z
dc.date.created2016
dc.date.issued2016-07-13
dc.identifier.urihttp://hdl.handle.net/10630/11823
dc.description.abstractAims. The individual susceptibility to cocaine addiction, a factor of interest in the understanding and prevention of this disorder, may be predicted by certain behavioral traits. However, these are not usually taken into account in research, making it difficult to identify whether they are a cause or a consequence of drug use. Methods. Male C57BL/6J mice underwent a battery of behavioral tests (elevated plus maze, hole-board, novelty preference in the Y maze, episodic-like object recognition memory and forced swimming test), followed by a cocaine-conditioned place preference (CPP) training to assess the reinforcing effect of the drug. In a second study, we aimed to determine the existence of neurobiological differences between the mice expressing high or low CPP by studying the number of neurons in certain addiction-related structures: the medial prefrontal cortex, the basolateral amygdala and the ventral tegmental area. Results. Anxiety-like behaviors in the elevated plus maze successfully predicted the cocaine-CPP behavior, so that the most anxious mice were also more likely to search for cocaine in a CPP paradigm. In addition, these mice exhibited an increased number of neurons in the basolateral amygdala, a key structure in emotional response including anxiety expression, without differences in the others regions analyzed. Conclusions. Our results suggest a relevant role of anxiety as a psychological risk factor for cocaine vulnerability, with the basolateral amygdala as potential common neural center for both anxiety and addiction.es_ES
dc.description.sponsorshipUniversidad de Málaga, Campus de Excelencia Internacional Andalucía Tech. PSI2013-44901-P, FPU13/04819, CD12/00455, Red de Trastornos Adictivoses_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectCocaínaes_ES
dc.subjectToxicomaníaes_ES
dc.subject.otherCocaine-conditiones place referencees_ES
dc.subject.otherAnxietyes_ES
dc.subject.otherElevated-plus mazees_ES
dc.subject.otherBasolateral amygdalaes_ES
dc.titleBehavioral traits predicting cocaine-conditioned place reference in mice: role of anxiety adn the basolateral amygdalaes_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Psicología y Logopediaes_ES
dc.relation.eventtitle10th FENS Forum of Neuroscience 2016es_ES
dc.relation.eventplaceCopenhague (Denmark)es_ES
dc.relation.eventdatejulio, 2016es_ES
dc.rights.ccby-nc-nd


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