Mostrar el registro sencillo del ítem

dc.contributor.authorGarcía-Bonilla, María
dc.contributor.authorShumilov, Kirill
dc.contributor.authorPeñalver, Ana
dc.contributor.authorCastilla, Laura
dc.contributor.authorAlonso-Carrión, Francisco José 
dc.contributor.authorMárquez-Gómez, Javier 
dc.contributor.authorGarcía-Martín, María Luisa
dc.contributor.authorMuñoz, Carmen
dc.contributor.authorGutiérrez-Pérez, Antonia 
dc.contributor.authorJiménez-Lara, Antonio Jesús 
dc.date.accessioned2016-07-11T08:39:21Z
dc.date.available2016-07-11T08:39:21Z
dc.date.created2016
dc.date.issued2016-07-11
dc.identifier.urihttp://hdl.handle.net/10630/11797
dc.description.abstractBackground Cerebrospinal fluid accumulation in hydrocephalus produces an elevation of intraventricular pressure with pathological consequences on the periventricular brain parenchyma including ischemia, oedema, oxidative stress, and accumulation of metabolic waste products. Here we studied in the hyh mouse, an animal model of congenital hydrocephalus, the role of reactive astrocytes in this clinical degenerative condition. Materials and Methods Wild type and hydrocephalic hyh mice at 30 days of postnatal age were used. Three metabolites related to the oxidative and neurotoxic conditions were analysed in ex vivo samples (glutathione, glutamine and taurine) using High Resolution Magic Angle Spinning (HR-MAS). Glutathione synthetase and peroxidase, glutamine synthetase, kidney-type glutaminase (KGA), and taurine/taurine transporter were immunolocated in brain sections. Results Levels of the metabolites were remarkably higher in hydrocephalic conditions. Glutathione peroxidase and synthetase were both detected in the periventricular reactive astrocytes and neurons. Taurine was mostly found free in the periventricular parenchyma and in the reactive astrocytes, and the taurine transporter was mainly present in the neurons located in such regions. Glutamine synthetase was found in reactive astrocytes. Glutaminase was also detected in the reactive astrocytes and in periventricular neurons. These results suggest a possible protective response of reactive astrocytes against oxidative stress and neurotoxic conditions. Conclusions Astrocyte reaction seems to trigger an anti-oxidative and anti-neurotoxic response in order to ameliorate pathological damage in periventricular areas of the hydrocephalic mice.es_ES
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. PI15-00619 to AJJ.es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectHidrocefaliaes_ES
dc.subject.otherHydrocephaluses_ES
dc.subject.otherAstrocytees_ES
dc.titlePotential protective role of reactive astrocytes in the periventricular parenchyma in congenital hydrocephaluses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.centroFacultad de Cienciases_ES
dc.relation.eventtitle60th Annual Meeting of the Society for Research into Hydrocephalus and Spina Bifidaes_ES
dc.relation.eventplaceStirling, Escocia, Reino Unidoes_ES
dc.relation.eventdate29 de julio de 2016es_ES
dc.identifier.orcidhttp://orcid.orgorcid.org/0000-0001-5652-3626es_ES
dc.rights.ccby-nc-nd
dc.type.hasVersioninfo:eu-repo/semantics/submittedVersiones_ES


Ficheros en el ítem

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem