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dc.contributor.authorMillón-Peñuela, Carmelo 
dc.contributor.authorFlores-Burgess, Antonio 
dc.contributor.authorNarváez-Peláez, Manuel 
dc.contributor.authorBorroto Escuela, Dasiel Óscar
dc.contributor.authorSantín-Núñez, Luis Javier 
dc.contributor.authorNarváez-Bueno, José Ángel 
dc.contributor.authorFuxe, Kjell
dc.contributor.authorDíaz-Cabiale, Zaida 
dc.date.accessioned2015-10-06T08:36:10Z
dc.date.available2015-10-06T08:36:10Z
dc.date.created2015
dc.date.issued2015-10-06
dc.identifier.urihttp://hdl.handle.net/10630/10454
dc.descriptionPonencia Invitadaes_ES
dc.description.abstractGalanin (GAL) is involved in several functions including mood regulation. The GAL N-terminal fragment (1-15) [GAL(1-15)] also participates at central level and a differential role of GAL(1-15) compared with GAL has been proposed. In this work we have analysed if GAL(1-15) contributes to depression- and anxiety -related behaviours using the forced swimming test, tail suspension test, open field and light/dark test. We tested the involvement of the GAL receptor 2 (GALR2) in GAL(1-15) effects with the GAL receptor antagonist M871 and with an in vivo model of siRNA GALR2 knockdown rats. The proximity of GALR1 and GALR1 was also examined with the proximity ligation assay (PLA). GAL(1-15) induced strong depression-like and anxiogenic-like effects in all the tests. The involvement of the GALR2 was demonstrated with M871 and with the siRNA GALR2 knockdown rats. The PLA indicated the existence of GALR1-GALR2 heteroreceptor complexes in the dorsal hippocampus and especially in the dorsal raphe nucleus. Our results indicate that GAL(1-15) exerts strong depression-related and anxiogenic-like effects and may give the basis for the development of drugs targeting GALR1-GALR2 heteroreceptor complexes in the raphe-limbic system for the treatment of depression and anxiety. This study was supported by Junta de Andalucía CVI6476.es_ES
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectNeuropéptidoses_ES
dc.subject.otherGalanines_ES
dc.subject.otherGAL(1-15)es_ES
dc.subject.otherDepressiones_ES
dc.subject.otherAnxietyes_ES
dc.titleA Role For Galanin N-Terminal Fragment (1-15) In Anxiety And Depression in ratses_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Medicinaes_ES
dc.relation.eventtitleNeuropeptides 2015es_ES
dc.relation.eventplaceAberdeen, Escociaes_ES
dc.relation.eventdate28-Sep al 01-Oct 2015es_ES
dc.rights.ccby-nc-nd


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