Listar por tema "G protein-coupled receptors"
Mostrando ítems 1-9 de 9
-
Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8+ T cells
(CELLPRESS, 2021)Autotaxin (ATX; ENPP2) produces lysophosphatidic acid (LPA) that regulates multiple biological functions via cognate G protein-coupled receptors LPAR1-6. ATX/LPA promotes tumor cell migration and metastasis via LPAR1 and ... -
Exploratory, anxiety and spatial memory impairments are dissociated in mice lacking the LPA1 receptor
Castilla-Ortega, María Estela
; Sánchez-López, Jorge; Hoyo-Becerra, Carolina; Matas-Rico, Elisa; Zambrana-Infantes, Emma; Chun, Jerold; Rodríguez de Fonseca, Fernando; Pedraza-Benítez, María del Carmen; Estivill-Torrús, Guillermo; Santín-Núñez, Luis Javier[et al.] (Elsevier, 2010-07)
Lysophosphatidic acid (LPA) is a new, intercellular signalling molecule in the brain that has an important role in adult hippocampal plasticity. Mice lacking the LPA1 receptor exhibit motor, emotional and cognitive ... -
Glycerophosphodiesterase GDE2 Promotes Neuroblastoma Differentiation through Glypican Release and Is a Marker of Clinical Outcome
(Elsevier, 2016-10)Neuroblastoma is a pediatric embryonal malignancy characterized by impaired neuronal differentiation. A better understanding of neuroblastoma differentiation is essential for developing new therapeutic approaches. GDE2 ... -
LPA is a chemorepellent for B16 melanoma cells: action through the cAMP-elevating LPA5 receptor
(PLOS One, 2011-12)Lysophosphatidic acid (LPA), a lipid mediator enriched in serum, stimulates cell migration, proliferation and other functions in many cell types. LPA acts on six known G protein-coupled receptors, termed LPA1–6, showing ... -
On the balance of D2R-MOR and D4R-MOR in the dorsal and ventral striatum. Putative link to morphine dependence and addiction
Fores-Pons, Ramón; Narváez-Peláez, Manuel; Vasudevan, Lakshmi; Crespo-Ramírez, Minerva; Rivera-Ramírez, Alicia; Pérez de la Mora, Miguel; Stove, Christophe; Fuxe, Kjell; Borroto Escuela, Dasiel Óscar[et al.] (8th Mediterranean Neuroscience Society (MNS), 2022-05-30)
The widespread distribution of heteroreceptor complexes with allosteric receptor-receptor interactions in the CNS represents a novel integrative molecular mechanism in the plasma membrane of neurons and glial cells. It was ... -
On the role of GPCR heteroreceptor complexes neuromodulation of the Claustrum
(8th Mediterranean Neuroscience Society (MNS), 2022-05-30)G protein-coupled receptors (GPCRs) modulate the synaptic glutamate and GABA transmission of the claustrum. Our work focused on the transmitter-receptor relationships in the claustral catecholamine system and receptor-receptor ... -
On the Role of Neuropeptide Y Receptor 1 (NPY1R)-Galanin Receptor 2 (GALR2) Heteroreceptor Complexes in Enhancing Adult Hippocampal Neurogenesis and Cognitive Function
(UMA Editorial, 2024-09)This PhD thesis investigates the roles of Neuropeptide Y receptor 1 (NPY1R) homo- and heteroreceptor complexes, specifically NPY1R- galanin receptor 2 (GALR2) heteroreceptor complexes, within the Central Nervous System ... -
On the role of the balance of G protein-coupled receptor (GPCR) homo and heteroreceptor complexes and their integration of signals in neurons and astroglia. Relevance for brain disorders
(UMA Editorial, 2022)There exists substantial evidence for the existence of G protein-coupled receptor (GPCR) homo and heteroreceptor complexes with allosteric receptor-receptor interactions in the Central Nervous System (CNS). The formation ... -
Study of g protein-coupled receptor (gpcr) homo- and heteroreceptor complexes interactions in the central nervous system through proximity labelling techniques
(UMA Editorial, 2024)There exists substantial evidence for the existence of GPCR homo and heteroreceptor complexes with allosteric receptor-receptor interactions in the Central Nervous System (CNS). Through the receptor heteromerization the ...