Listar por autor "Lucena-González, María Isabel"
Mostrando ítems 41-54 de 54
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Potential benefit and lack of serious risk from corticosteroids in drug-induced liver injury: an international, multicentre, propensity score-matched analysis
Niu, Hao; Ma, Jiayi; Medina-Cáliz, Inmaculada
; Robles-Díaz, María Mercedes; Bonilla-Toyos, Elvira; Ghabril, Marwan; Lucena-González, María Isabel; Alvarez-Alvarez, Ismael; Andrade-Bellido, Raúl Jesús[et al.] (Wiley, 2022-12-22)
Background: The use of corticosteroids to treat patients with idiosyncratic drug-induced liver injury (DILI) relies on empirical clinical decisions. Aim: To investigate the relationship between corticosteroids and ... -
Preclinical models of idiosyncratic drug-induced liver injury (iDILI): Moving towards prediction
Segovia-Zafra, Antonio; Di Zeo-Sánchez, Daniel Enrique; López-Gómez, Carlos; Pérez-Valdés, Zeus; García-Fuentes, Eduardo; Andrade-Bellido, Raúl Jesús; Lucena-González, María Isabel; Villanueva-Paz, Marina[et al.] (Elsevier, 2021-12)
Idiosyncratic drug-induced liver injury (iDILI) encompasses the unexpected harms that pre- scription and non-prescription drugs, herbal and dietary supplements can cause to the liver. iDILI remains a major public health ... -
Prevention and management of idiosyncratic drug-induced liver injury: Systematic review and meta-analysis of randomised clinical trials
Niu, Hao; Sanabria-Cabrera, Judith Adriana; Alvarez-Alvarez, Ismael; Robles-Díaz, María Mercedes; Stankeviciute, Simona; Aithal, Guruprasad P.; Bjornsson, Einar S.; Andrade-Bellido, Raúl Jesús; Lucena-González, María Isabel; Sanabria-Cabrera, Judith Adriana[et al.] (Elsevier, 2021-02)
Conducting randomised clinical trials (RCTs) in idiosyncratic drug-induced liver injury (DILI) is challenging. This systematic review aims to summarise the design and findings of RCTs in the prevention and management of ... -
Prior drug allergies are associated with worse outcome in patients with idiosyncratic drug-induced liver injury: A machine learning approach for risk stratification
Niu, Hao; Solis-Muñoz, Pablo; García-Cortés, Miren; Sanabria-Cabrera, Judith Adriana; Robles-Díaz, María Mercedes; Romero-Flores, Rocío; Bonilla-Toyos, Elvira; Ortega-Alonso, Aida; Pinazo-Bandera, José M.; Cabello-Porras, María Rosario; Bessone, Fernando; Hernandez, Nelia; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús; Medina-Cáliz, Inmaculada; Alvarez-Alvarez, Ismael[et al.] (Elsevier, 2023-12-08)
The impact of prior drug allergies (PDA) on the clinical features and outcomes of patients who develop idiosyncratic drug-induced liver injury (DILI) is largely unknown. We aimed to assess the clinical presentation and ... -
Profile of herbal and dietary supplements induced liver injury in Latin America: A systematic review of published reports
Santos, Genario; Gasca, Jessica; Parana, Raymundo; Nunes, Vinicius; Schinnoni, Maria; Medina-Cáliz, Inmaculada; Cabello-Porras, María Rosario; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús[et al.] (WILEY, 2020-06)
Hepatotoxicity related to HDS is a growing global health issue. We have undertaken a systematic review of published case reports and case series from LA from 1976 to 2020 to describe the clinical features of HDS related ... -
Proteína c activada y polimorfismo genético en la sepsis grave
(Universidad de Málaga, Servicio de Publicaciones, 2011)Introducción: La proteína C activada (APC) tiene propiedades antianticoagulantes, profibrinoliticas, antiinflamatorias, antiapoptósicas y de estabilización de la membrana endotelial en la sepsis. Objetivos: Determinar ... -
Rechallenge in idiosyncratic drug-induced liver injury: An analysis of cases in two large prospective registries according to existing definitions
Pinazo-Bandera, José M.; Niu, Hao; Alvarez-Alvarez, Ismael; Medina-Cáliz, Inmaculada; Del Campo-Herrera, Enrique; Ortega-Alonso, Aida; Robles-Díaz, María Mercedes; Hernandez, Nelia; Parana, Raymundo; Nunes, Vinicius; Girala, M.; Bessone, Fernando; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús; García-Cortés, Miren[et al.] (Elsevier, 2024-05)
Los datos sobre la reexposición positiva en la lesión hepática inducida por fármacos (DILI) idiosincrásica son escasos. Apuntamos a analizar la presentación clínica, el resultado y los fármacos asociados con la reexposición ... -
Rechallenge in idiosyncratic drug-induced liver injury: An analysis of cases in two large prospective registries according to existing definitions.
Pinazo-Bandera, Jose M.; Niu, Hao; Alvarez-Alvarez, Ismael; Medina-Cáliz, Inmaculada; Del Campo-Herrera, Enrique; Ortega-Alonso, Aida; Robles‑Diaz, Mercedes; Hernandez, Nelia; Parana, Raymundo; Nunes, Vinicius; Girala, Marcos; Bessone, Fernando; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús; García-Cortés, Miren[et al.] (Elsevier, 2024)
Introduction: Data on positive rechallenge in idiosyncratic drug-induced liver injury (DILI) are scarce. We aim to analyse the clinical presentation, outcome and drugs associated with positive rechallenge in two DILI ... -
Recreational Drugs and the Risk of Hepatocellular Carcinoma
Pinazo-Bandera, José M.; García-Cortés, Miren; Segovia-Zafra, Antonio; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús (IOAP-MPDI, 2022-11-02)
Hepatocellular carcinoma represents an important contributor to the global cancer-related burden, and liver cirrhosis is the main risk factor for its development. Conventional or illegal drug consumption is a potential but ... -
Roadmap to DILI research in Europe. A proposal from COST action ProEuroDILINet
Lucena-González, María Isabel; Villanueva-Paz, Marina; Alvarez-Alvarez, Ismael; Aithal, Guruprasad P.; Bjornsson, Einar S.; Cakan-Akdogan, G.; Cubero, Francisco Javier; Esteves, Freddy; Falcón-Pérez, Juan Manuel; Fromenty, B.; Garcia-Ruiz, C.; Grove, J.I.; Konu, O.; Kranendonk, M.; Kullak-Ublick, Gerd A; Miranda, J.P.; Remesal-Doblado, A.; Sancho-Bru, P.; Nelson, L.; Andrade-Bellido, Raúl Jesús; Fernandez-Checa, J.C.[et al.] (Elsevier, 2023-12-28)
In the current article the aims for a constructive way forward in Drug-Induced Liver Injury (DILI) are to highlight the most important priorities in research and clinical science, therefore supporting a more informed, ... -
Role of chemical structures and the 1331T>C bile salt export pump polymorphism in idiosyncratic drug-induced liver injury
Ulzurrun, Eugenia; Stephens, Camilla; Crespo, Esperanza; Ruiz-Cabello, Francisco; Ruiz-Nuñez, Julia; Saenz-López, Pablo; Moreno-Herrera, Inmaculada; Robles-Díaz, María Mercedes; Hallal, Hacibe; Moreno-Planas, José María; Cabello-Porras, María Rosario; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús[et al.] (WILEY, 2013-04)
Background & aims: Several pharmaceutical compounds have been shown to exert inhibitory effects on the bile salt export pump (BSEP) encoded by the ABCB11 gene. We analysed the combined effect on drug-induced liver injury ... -
Serious liver injury induced by Nimesulide: an international collaboration study reporting 57 cases
Bessone, Fernando; Hernandez, Nelia; Mendizabal, Manuel; Ridruejo, Ezequiel; Gualano, Gisela; Fassio, Eduardo; Peralta, Mirta; Fainboim, Hugo; Anders, Margarita; Tanno, Hugo; Tanno, Federico; Parana, Raymundo; Medina-Cáliz, Inmaculada; Robles-Díaz, María Mercedes; Alvarez-Alvarez, Ismael; Niu, Hao; Stephens, Camilla; Colombato, Luis; Arrese, Marco; Reggiardo, Maria Virginia; Ono, Suzane Kioko; Carrilho, Flair; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús[et al.] (Springer, 2021-03-24)
Nimesulide is a non-steroidal anti-inflammatory drug still marketed in many countries. We aim to analyze the clinical phenotype, outcome, and histological features of nimesulide-induced liver injury (nimesulide-DILI). We ... -
Statins: Hepatic Disease and Hepatotoxicity Risk.
Cueto-Galán, Raquel; Valdivielso-Felices, Pedro; Lucena-González, María Isabel; García-Arias, Carlota; Andrade-Bellido, Raúl Jesús; González-Santos, Pedro[et al.] (Scientific Research Publishing, 2008)
Los inhibidores de la hidroxi-metil-glutaril coenzima A (HMG-CoA) reductasa, generalmente conocidos como estatinas, tienen un buen perfil de seguridad y son uno de los fármacos más recetados en Europa. Sin embargo, las ... -
Therapeutic management of idiosyncratic drug‑induced liver injury and acetaminophen hepatotoxicity in the paediatric population: a systematic review.
Niu, Hao; Atallah, Edmond; Alvarez-Alvarez, Ismael; Medina-Cáliz, Inmaculada; Aithal, Guruprasad P.; Arikan, Cigdem; Andrade-Bellido, Raúl Jesús; Lucena-González, María Isabel[et al.] (Springer Nature, 2022)
Introduction: Drug-induced liver injury (DILI) is a rare but serious adverse event that can progress to acute liver failure (ALF). The evidence for treatment of DILI in children is scarce. Objective: We aim to comprehensively ...