Listar por autor "Andrade-Bellido, Raúl Jesús"
Mostrando ítems 21-40 de 51
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Genetic polymorphisms of CYP2C9 and CYP2C19 are not related to drug-induced idiosyncratic liver injury (DILI)
Pachkoria, K.; Lucena-González, María Isabel
; Ruiz-Cabello, Francisco; Crespo, Esperanza; Cabello-Porras, María Rosario; Andrade-Bellido, Raúl Jesús[et al.] (2007-01-29)
Background and purpose: The general view on the pathogenesis of drug-induced idiosyncratic liver injury (DILI) is that parent compounds are rendered hepatotoxic by metabolism, mainly by cytochrome (CYP) 450, although other ... -
Hepatic safety of atypical antipsychotics: current evidence and future directions
Slim, Mahmoud; Medina-Cáliz, Inmaculada; González-Jiménez, Andrés; Cabello-Porras, María Rosario; Mayoral Cleries, Fermín; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús[et al.] (Springer, ADIS INT LTD, 2016-10)
The newer atypical antipsychotic agents (AAPs) represent an attractive therapeutic option for a wide range of psychotic disorders, including schizophrenia and bipolar mania, because of the reduced risk of disabling ... -
Hepatitis C virus point-of-care microelimination approach in a vulnerable population in the South of Spain.
Pinazo-Bandera, Jose M.; Aranda, Jesús; García-García, Alberto M.; Alcántara, Ramiro; Ortega-Alonso, Aida; Del Campo-Herrera, Enrique; Clavijo-Frutos, Encarnación; García-Escaño, M. Dolores; Ruiz Ruiz, Juan J.; Morales-Herrera, Mónica; Valle-López, Vanesa; Martín-Alarcón, Rosa; Viciana, Isabel; Jiménez, Juan Bautista; Fernández-García, Félix; Toro-Ortiz, Juan Pedro; Sánchez-Yáñez, Elena; Alvarez-Alvarez, Ismael; Andrade-Bellido, Raúl Jesús; Robles-Díaz, María Mercedes; García-Cortés, Miren[et al.] (Oxford Academic, 2024-01-22)
Background: Since the introduction of direct-acting antivirals, thousands of chronic hepatitis C patients have been successfully treated. However, vulnerable populations have a higher prevalence of hepatitis C virus (HCV) ... -
Herbal and dietary supplement-induced liver injuries in the spanish DILI registry
Medina-Cáliz, Inmaculada; García-Cortés, Miren; González-Jiménez, Andrés; Cabello-Porras, María Rosario; Robles-Díaz, María Mercedes; Sanabria-Cabrera, Judith Adriana; Sanjuan-Jimenez, Rocio; Ortega-Alonso, Aida; García-Muñoz, Beatriz; Moreno, Inmaculada; Jiménez-Pérez, Miguel; Fernández, M. Carmen; Ginés, Pere; Prieto, Martin; Conde, Isabel; Hallal, Hacibe; Soriano, German; Roman, Eva; Castiella, Agustin; Blanco-Reina, Encarnación; Montes, Maria R; Quiros-Cano, Marta; Martín-Reyes, Flores; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús[et al.] (Elsevier, 2018-01)
There have been increasing reports of liver injury associated with use of herbal and dietary supplements.We collected and analyzed data on demographic and clinical features, along with biochemical parameters, of 32 patients ... -
Herbal and dietary supplements-induced liver injury in Latin America: Experience from the LATINDILI Network
Bessone, Fernando; García-Cortés, Miren; Medina-Cáliz, Inmaculada; Hernandez, Nelia; Parana, Raymundo; Mendizabal, Manuel; Schinoni, María I.; Ridruejo, Ezequiel; Nunes, Vinicius; Peralta, Mirta; Santos, Genario; Anders, Margarita; Chiodi, Daniela; Tagle, Martin; Montes, Pedro; Carrera, Enrique; Arrese, Marco; Lizarzabal, M. Isabel; Alvarez-Alvarez, Ismael; Caballano-Infantes, Estefanía; Niu, Hao; Pinazo, Jose; Cabello-Porras, María Rosario; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús[et al.] (Elsevier, 2022)
Background: Herbal and dietary supplements (HDS) consumption, a growing cause of hepatotoxicity, is a common practice among Latin-American populations. Objectives: To evaluate clinical, laboratory features and outcome ... -
Histological and serological features of acute liver injury after SARS-CoV-2 vaccination
Codoni, Greta; Kirchner, Theresa; Engel, Bastian; Villamil, Alejandra Maria; Efe, Cumali; Friedrich Stättermayer, Albert; Weltzsch, Jan Philipp; Sebode, Marcial; Bernsmeier, Christine; Lleo, Ana; Gevers, Tom JG.; Kupčinskas, Limas; Castiella, Agustin; Pinazo, Jose; De Martin, Eleonora; Bobis, Ingrid; Damgaard Sandahl, Thomas; Pedica, Federica; Invernizzi, Federica; Del Poggio, Paolo; Bruns, Tony; Kolev, Mirjam; Semmo, Nasser; Bessone, Fernando; Giguet, Baptiste; Poggi, Guido; Ueno, Masayuki; Jang, Helena; Elpek, Gülsüm Özlem; Karadağ Soylu, Neşe; Cerny, Andreas; Wedemeyer, Heiner; Vergani, Diego; Mieli-Vergani, Giorgina; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús; Zen, Yoh; Taubert, Richard; Terziroli Beretta-Piccoli, Benedetta[et al.] (Elsevier, 2022)
Liver injury with autoimmune features after vaccination against Severe Acute Respiratory Syndrome Coronavirus type 2 (SARS-CoV-2) is increasingly reported. We investigated a large international cohort of patients with acute ... -
Incidence and prevalence of acute hepatitis E virus infection in patients with suspected Drug-Induced Liver Injury in the Spanish DILI Registry
Sanabria-Cabrera, Judith Adriana; Sanjuan-Jimenez, Rocio; Clavijo-Frutos, Encarnación; Medina-Cáliz, Inmaculada; González-Jiménez, Andrés; García-Cortés, Miren; Ortega-Alonso, Aida; Jiménez-Pérez, Miguel; González-Grande, Rocío; Stephens, Camilla; Robles-Díaz, María Mercedes; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús[et al.] (2020)
Background and Aims: Drug-induced liver injury (DILI) presents with a wide phenotypic spectrum requiring an extensive differential diagnosis. Hepatitis E virus (HEV) is not systematically ruled out during acute hepatitis ... -
Lymphocyte Profile and Immune Checkpoint Expression in Drug-Induced Liver Injury: An Immunophenotyping Study
Cueto-Sánchez, Alejandro; Niu, Hao; Del Campo-Herrera, Enrique; Robles-Díaz, María Mercedes; Sanabria-Cabrera, Judith Adriana; Ortega-Alonso, Aida; García-Cortés, Miren; González-Grande, Rocío; Jiménez-Pérez, Miguel; Ruiz-Cabello, Francisco; Andrade-Bellido, Raúl Jesús; Lucena-González, María Isabel[et al.] (Wiley, 2021-09-20)
The identification of specific HLA risk alleles in drug-induced liver injury (DILI) points toward an important role of the adaptive immune system in DILI development. In this study, we aimed to corroborate the role of an ... -
Membrane vesicles of toxigenic Clostridioides difficile affect the metabolism of liver hepG2 cells
Caballano-Infantes, Estefanía; Ho-Plágaro, Ailec; López-Gómez, Carlos; Martín-Reyes, Flores; Rodríguez-Pacheco, Francisca; Taminiau, Bernard; Daube, Georges; Garrido Sánchez, Lourdes; Alcaín-Martínez, Guillermo; Andrade-Bellido, Raúl Jesús; García-Cortés, Miren; Lucena-González, María Isabel; García Fuentes, Eduardo; Rodriguez-Diaz, Cristina[et al.] (MDPI, 2023-03-27)
Clostridioides difficile infection (CDI) appears to be associated with different liver diseases. C. difficile secretes membrane vesicles (MVs), which may be involved in the development of nonalcoholic fatty liver disease ... -
Methionine Cycle Rewiring by Targeting miR-873-5p Modulates Ammonia Metabolism to Protect the Liver from Acetaminophen
Rodríguez-Agudo, Rubén; Goikoetxea-Usandizaga, Naroa; Serrano-Maciá, Marina; Fernández-Tussy, Pablo; Fernández-Ramos, David; Lachiondo-Ortega, Sofía; González-Recio, Irene; Gil-Pitarch, Clàudia; Mercado-Gómez, María; Bizkarguenaga, Maider; Lopitz-Otsoa, Fernando; Petrov, Petar; Bravo, Miren; Martijn Van Liempd, Sebastiaan; Falcón-Pérez, Juan Manuel; Zabala-Letona, Amaia; Carracedo, Arkaitz; Vicente Castell, Jose; Jover, Ramiro; Martínez-Cruz, Luis Alfonso; Cardoso Delgado, Teresa; Cubero, Francisco Javier; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús; Mabe, Jon; Simón, Jorge; Martínez-Chantar, María Luz[et al.] (IOAP-MPDI, 2022-04-30)
Drug-induced liver injury (DILI) development is commonly associated with acetaminophen (APAP) overdose, where glutathione scavenging leads to mitochondrial dysfunction and hepatocyte death. DILI is a severe disorder without ... -
Microbiota diversity in nonalcoholic fatty liver disease and in drug-induced liver injury
Rodriguez-Diaz, Cristina; Taminiau, Bernard; García-García, Alberto; Cueto-Sánchez, Alejandro; Robles-Díaz, María Mercedes; Ortega-Alonso, Aida; Martín-Reyes, Flores; Daube, Georges; Sanabria-Cabrera, Judith Adriana; Jiménez-Pérez, Miguel; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús; García Fuentes, Eduardo; García-Cortés, Miren[et al.] (Elsevier, 2022-08)
The gut microbiota could play a significant role in the progression of nonalcoholic fatty liver disease (NAFLD); however, its relevance in drug-induced liver injury (DILI) remains unexplored. Since the two hepatic disorders ... -
Modeling drug-induced liver injury: current status and future prospects.
Di Zeo-Sánchez, Daniel Enrique; Segovia-Zafra, Antonio; Matilla-Cabello, Gonzalo; Pinazo-Bandera, José; Andrade-Bellido, Raúl Jesús; Lucena-González, María Isabel; Villanueva-Paz, Marina[et al.] (Taylor & Francis, 2022-09-16)
Introduction Idiosyncratic drug-induced liver injury (iDILI) is a challenging and unpredictable multifactorial condition. At present, validated preclinical models for the prediction of the hepatotoxic potential of a given ... -
N-acetylcysteine for the management of non-acetaminophen drug-induced liver injury in adults: a systematic review.
Sanabria-Cabrera, Judith Adriana; Tabbai-Amal, Sara; Niu, Hao; Alvarez-Alvarez, Ismael; Licata, Anna; Bjornsson, Einar S.; Andrade-Bellido, Raúl Jesús; Lucena-González, María Isabel[et al.] (Frontiers, 2022)
Introduction: Idiosyncratic drug-induced liver injury (DILI) is a rare adverse reaction to drugs and other xenobiotics. DILI has different grades of severity and may lead to acute liver failure (ALF), for which there is ... -
Nitrofurantoin‑induced liver injury: long‑term follow‑up in two prospective DILI registries
Bessone, Fernando; Ferrari, Antonella; Hernandez, Nelia; Mendizabal, Manuel; Zerega, Alina; Tanno, Federico; Reggiardo, Maria Virginia; Vorobioff, Julio; Tanno, Hugo; Arrese, Marco; Nunes, Vinicius; Tagle, Martin; Medina-Cáliz, Inmaculada; Robles‑Diaz, Mercedes; Niu, Hao; Alvarez-Alvarez, Ismael; Stephens, Camilla; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús[et al.] (Springer Nature, 2022-11-22)
Nitrofurantoin is a synthetic antibiotic that is recommended as first-choice treatment for uncomplicated urinary tract infections. The prescription of this drug has increased dramatically, especially in Latin American ... -
Nomenclature, diagnosis and management of drug-induced autoimmune-like hepatitis (DI-ALH): An expert opinion meeting report
Andrade-Bellido, Raúl Jesús; Aithal, Guruprasad P.; De Boer, Ynto S.; Liberal, Rodrigo; Gerbes, Alexander L; Regev, Arie; Terziroli Beretta-Piccoli, Benedetta; Schramm, Christoph; Kleiner, David E.; De Martin, Eleonora; Kullak-Ublick, Gerd A; Stirnimann, Guido; Devarbhavi, Harshad; Vierling, John M.; Manns, Michael P.; Sebode, Marcial; Londoño, María Carlota; Avigan, Mark; Robles-Díaz, María Mercedes; García-Cortés, Miren; Atallah, Edmond; Heneghan, Michael; Chalasani, Naga; Trivedi, Palak J.; Hayashi, Paul H.; Taubert, Richard; Fontana, Robert J.; Weber, Sabine; Oo, Ye Htun; Zen, Yoh; Licata, Anna; Lucena-González, María Isabel; Mieli-Vergani, Giorgina; Vergani, Diego; Bjornsson, Einar S.[et al.] (Elsevier, 2023)
Drug-induced liver injury (DILI) can mimic almost all other liver disorders. A phenotype increasingly ascribed to drugs is autoimmune-like hepatitis (ALH). This article summarises the major topics discussed at a joint ... -
Oxidative Stress in Drug-Induced Liver Injury (DILI): From Mechanisms to Biomarkers for Use in Clinical Practice
Villanueva-Paz, Marina; Morán, Laura; López-Alcántara, Nuria; Freixo, Cristiana; Andrade-Bellido, Raúl Jesús; Lucena-González, María Isabel; Cubero, Francisco Javier[et al.] (MDPI, 2021-03-05)
Idiosyncratic drug-induced liver injury (DILI) is a type of hepatic injury caused by an uncommon drug adverse reaction that can develop to conditions spanning from asymptomatic liver laboratoryabnormalitiestoacuteliverfa ... -
Pharmacogenomics in Drug Induced Liver Injury.
Andrade-Bellido, Raúl Jesús; Agúndez, José; Lucena-González, María Isabel; Martínez, Carmen; Cueto-Galán, Raquel; García-Martín, Elena[et al.] (Betham Science, 2009)
La lesión hepática inducida por fármacos (DILI) es un efecto adverso grave. La mayoría de los casos de DILI son idiosincrásicos y se han postulado varios mecanismos para explicar por qué algunos sujetos desarrollan DILI ... -
Potential benefit and lack of serious risk from corticosteroids in drug-induced liver injury: an international, multicentre, propensity score-matched analysis
Niu, Hao; Ma, Jiayi; Medina-Cáliz, Inmaculada; Robles-Díaz, María Mercedes; Bonilla-Toyos, Elvira; Ghabril, Marwan; Lucena-González, María Isabel; Alvarez-Alvarez, Ismael; Andrade-Bellido, Raúl Jesús[et al.] (Wiley, 2022-12-22)
Background: The use of corticosteroids to treat patients with idiosyncratic drug-induced liver injury (DILI) relies on empirical clinical decisions. Aim: To investigate the relationship between corticosteroids and ... -
Preclinical models of idiosyncratic drug-induced liver injury (iDILI): Moving towards prediction
Segovia-Zafra, Antonio; Di Zeo-Sánchez, Daniel Enrique; López-Gómez, Carlos; Pérez-Valdés, Zeus; García-Fuentes, Eduardo; Andrade-Bellido, Raúl Jesús; Lucena-González, María Isabel; Villanueva-Paz, Marina[et al.] (Elsevier, 2021-12)
Idiosyncratic drug-induced liver injury (iDILI) encompasses the unexpected harms that pre- scription and non-prescription drugs, herbal and dietary supplements can cause to the liver. iDILI remains a major public health ... -
Prevention and management of idiosyncratic drug-induced liver injury: Systematic review and meta-analysis of randomised clinical trials
Niu, Hao; Sanabria-Cabrera, Judith Adriana; Alvarez-Alvarez, Ismael; Robles-Díaz, María Mercedes; Stankeviciute, Simona; Aithal, Guruprasad P.; Bjornsson, Einar S.; Andrade-Bellido, Raúl Jesús; Lucena-González, María Isabel; Sanabria-Cabrera, Judith Adriana[et al.] (Elsevier, 2021-02)
Conducting randomised clinical trials (RCTs) in idiosyncratic drug-induced liver injury (DILI) is challenging. This systematic review aims to summarise the design and findings of RCTs in the prevention and management of ...