Listar por autor "Núñez-Díaz, Cristina"
Mostrando ítems 21-26 de 26
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Microtubule stabilization reduces amyloid pathology and improves synaptic/memory deficits in APP/PS1 mice
Sánchez-Varo, Raquel María
; Fernández-Valenzuela, Juan José; Muñoz-Castro, Clara; De Castro Carratalá, Vanessa; Sánchez-Mejías, Elisabeth; Navarro, Victoria; Jiménez, Sebastián; Núñez-Díaz, Cristina; Gómez-Arboledas, Ángela; Moreno-González, Inés; Moyano, F; Vizuete, María Luisa; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (Alzheimer disease & Parkinson disease Conference 2021, 2021)
Aims: Cognitive decline in Alzheimer's disease (AD) is highly related to synaptic/neuronal loss. Tau hyperphosphorylation destabilizes microtubules leading to axonal transport failure and generation of dystrophic neurites, ... -
Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease
Gómez-Arboledas, Ángela; Davila, Jose Carlos; Sánchez-Mejías, Elisabeth; Navarro, Victoria; Núñez-Díaz, Cristina; Sánchez-Varo, Raquel María; Sanchez-Mico, Maria Virtudes; Trujillo-Estrada, Laura Isabel; Fernández-Valenzuela, Juan José; Vizuete, Marisa; Comella, Joan X.; Galea, Elena; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (Wiley, 2018-03)
Reactive astrogliosis, a complex process characterized by cell hypertrophy and upregulation of components of intermediate filaments, is a common feature in brains of Alzheimer's patients. Reactive astrocytes are found in ... -
Soluble phospho-tau from Alzheimer's disease hippocampus drives microglial degeneration.
Sánchez-Mejías, Elisabeth; Navarro, Victoria; Jiménez, Sebastián; Sanchez-Mico, Maria Virtudes; Sánchez-Varo, Raquel María; Núñez-Díaz, Cristina; Trujillo-Estrada, Laura Isabel; Dávila-Cansino, José Carlos; Vizuete, Marisa; Gutiérrez-Pérez, Antonia; Vitorica Ferrández, Javier[et al.] (Springer Nature, 2016-10-14)
El papel de la microglía en la enfermedad de Alzheimer (AD) aún no ha sido esclarecido. En este trabajo demostramos la existencia de una débil respuesta microglial en el hipocampo de pacientes, en contraste con la masiva ... -
The effect of different amyloid seeds and animal hosts on amyloid propagation in Alzheimer's Disease
Andreo-López, Juana; Cantero-Molina, Francisco; Bettinetti-Luque, Miriam; Do Huynh, Kelly; Thu Nguyen, Marie Minh; Cheung, Alwin; Pham Tran, Janine; Trujillo-Estrada, Laura Isabel; Núñez-Díaz, Cristina; Martini, Alessandra C.; Forner, Stefania; Gutiérrez-Pérez, Antonia; LaFerla, Frank; Baglietto-Vargas, David[et al.] (2022-07-13)
Abstract text: Alzheimer's Disease is a neurodegenerative proteinopathy in which recent evidence indicates that Aβ can misfold and aggregate into seeds that structurally corrupt native proteins, mimicking a prion-like ... -
Transgenic Mouse Models of Alzheimer’s Disease: An Integrative Analysis
Sánchez-Varo, Raquel María; Mejías-Ortega, Marina; Fernández-Valenzuela, Juan José; Núñez-Díaz, Cristina; Cáceres Palomo, Laura; Vegas-Gómez, Laura; Sánchez-Mejías, Elisabeth; Trujillo-Estrada, Laura Isabel; Moreno-González, Inés; García-León, Juan Antonio; Vizuete, María Luisa; Vitorica Ferrández, Javier; Baglietto-Vargas, David; Gutiérrez-Pérez, Antonia[et al.] (IOAP-MPDI, 2022-05-12)
Alzheimer’s disease (AD) constitutes the most prominent form of dementia among elderly individuals worldwide. Disease modeling using murine transgenic mice was first initiated thanks to the discovery of heritable mutations ... -
Understanding microglial responses in the frontal cortex of alzheimer´s disease patients
Mejías-Ortega, Marina; Sánchez-Mejías, Elisabeth; Navarro, Victoria; Núñez-Díaz, Cristina; Sánchez-Varo, Raquel María; Jiménez, Sebastián; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2021-03-09)
Microglial cells, the immune cells of the brain, and the neuroinflammatory process associated, have been postulated as a critical factor in AD pathogenesis, since the identification of genetic risk factors related ...