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Galanin (1-15) potentiates the antidepres-sant-like effects induced by Escitalopram in a rat model of depression
García-Durán, Laura; Flores-Burgess, Antonio
; Cantero-García, Noelia; Puigcerver-Martínez, Araceli
; Narváez-Bueno, José Ángel
; Fuxe, Kjell; Santín-Núñez, Luis Javier
; Millón-Peñuela, Carmelo
; Díaz-Cabiale, Zaida
[et al.] (2021-10-07)
Selective 5-HT reuptake inhibitor antidepressants (SSRIs) are the first choice in major depressive disorder (MDD), but 50% of affected patients do not show improvement. Galanin(1-15) [GAL(1-15)] enhanced Fluoxetine ... -
Galanin (1–15) enhances the antidepressant effects of the 5-HT1A receptor agonist 8-OH-DPAT: involvement of the raphe-hippocampal 5-HT neuron system
Millón-Peñuela, Carmelo; Flores-Burgess, Antonio
; Narváez-Peláez, Manuel
; Borroto Escuela, Dasiel Óscar; Santín-Núñez, Luis Javier
; Gago-Calderón, Belén
; Narváez-Bueno, José Ángel
; Fuxe, Kjell; Díaz-Cabiale, Zaida
[et al.] (Springer Nature, 2016-01-20)
Galanin N-terminal fragment (1–15) [GAL(1–15)] is associated with depression-related and anxiogenic-like effects in rats. In this study, we analyzed the ability of GAL(1–15) to modulate 5-HT1A receptors (5-HT1AR), a key ... -
Galanin (1–15)-fluoxetine interaction in the novel object recognition test. Involvement of 5-HT1A receptors in the prefrontal cortex of the rats
Flores-Burgess, Antonio; Millón-Peñuela, Carmelo
; Gago-Calderón, Belén
; García-Durán, Laura
; Coveñas, Rafael; Narváez-Bueno, José Ángel
; Fuxe, Kjell; Santin, Luis; Díaz-Cabiale, Zaida
[et al.] (Elsevier, 2019)
Galanin (1-15) [GAL(1–15)] participates in mood regulation and depression. GAL(1–15) is also able to enhance the antidepressant effects induced by Fluoxetine (FLX) in the forced swimming test through interaction between ... -
Galanin (1–15)-fluoxetine interaction in the novel object recognition test. Involvement of 5-HT1A receptors in the prefrontal cortex of the rats.
Flores-Burgess, Antonio; Millón-Peñuela, Carmelo
; Gago-Calderón, Belén
; García-Durán, Laura
; Cantero-García, Noelia; Caveñas, Rafael; Narváez-Bueno, José Ángel
; Fuxe, Kjell; Santín-Núñez, Luis Javier
; Díaz-Cabiale, Zaida
[et al.] (Elsevier, 2019-09-01)
Galanin (1-15) [GAL(1–15)] participates in mood regulation and depression. GAL(1–15) is also able to enhance the antidepressant effects induced by Fluoxetine (FLX) in the forced swimming test through interaction between ... -
Galanin and galanin fragment 1-15 modulate antidepressant responses by targeting 5-HT1AR-GALR heteroreceptor complexes of the ascending midbrain serotonin pathways.
Millón-Peñuela, Carmelo; Flores-Burgess, Antonio
; Narváez-Peláez, Manuel
; Borroto Escuela, Dasiel Óscar; Santín-Núñez, Luis Javier
; Narváez-Bueno, José Ángel
; Fuxe, Kjell; Díaz-Cabiale, Zaida
[et al.] (Cinp, 2016-07-03)
Mood disorders, including depression and anxiety, are among the most prevalent mental illnesses with high socioeconomic impact. Although the underlying mechanisms have not yet been clearly defined in the last decade the ... -
Galanin and Neuropeptide Y Interaction Enhances Proliferation of Granule Precursor Cells and Expression of Neuroprotective Factors in the Rat Hippocampus with Consequent Augmented Spatial Memory
Mirchandani-Duque, Marina; Barbancho-Fernández, Miguel Ángel; López-Salas, Alexander; Álvarez-Contino, José Erik; García-Casares, Natalia
; Fuxe, Kjell; Borroto Escuela, Dasiel Óscar; Narváez-Peláez, Manuel
[et al.] (IOAP-MPDI, 2022-06-01)
Dysregulation of hippocampal neurogenesis is linked to several neurodegenereative diseases, where boosting hippocampal neurogenesis in these patients emerges as a potential therapeutic approach. Accumulating evidence for ... -
Galanin and Neuropeptide Y Interaction Enhances Proliferation of Granule Precursor Cells and Expression of Neuroprotective Factors in the Rat Hippocampus: Role in depression and memory
Mirchandani-Duque, Marina; Barbancho-Fernández, Miguel Ángel; López-Salas, Alexander; Álvarez-Contino, José Erik; García-Casares, Natalia
; Fuxe, Kjell; Borroto Escuela, Dasiel Óscar; Narváez-Peláez, Manuel
[et al.] (2022-09-22)
Neuropeptide Y(NPY) Y1 receptor (Y1R) and galanin (GAL) receptor 2 (GALR2) interact in brain regions responsible for mood control and learning and memory processes, emphasizing the hippocampus. The current study assesses ... -
Galanin and Neuropeptide Y interaction leads to antidepressant effects through hippocampal cell proliferation.
Narváez-Peláez, Manuel; Fores-Pons, Ramón; Pita-Rodríguez, Mariana; Fuxe, Kjell; Borroto Escuela, Dasiel Óscar (2020-09-01)
Galanin (GAL) interacts with Neuropeptide Y Y1 receptors (NPYY1R) in several regions of the central nervous system associated with mood and motivation, through GAL receptor 2 and NPYY1 receptor 1 (GALR2/NPYY1R) heterodimers. ... -
Galanin and neuropeptide Y interactions elicit antidepressant activity linked to neuronal precursor cells of the dentate gyrus in the ventral hippocampus
Borroto-Escuela, Dasiel O.; Pita-Rodríguez, Mariana; Fores-Pons, Ramón; Barbancho-Fernández, Miguel Ángel; Fuxe, Kjell; Narváez-Peláez, Manuel
[et al.] (Wiley, 2021-02-21)
A need for new antidepressants is necessary since traditional antidepressants have several flaws. Neuropeptide Y(NPY) Y1 receptor (NPYY1R) and galanin (GAL) receptor 2 (GALR2) interact in several regions of the limbic ... -
Galanin and neuropeptide Y interactions linked to neuronal precursor cells of the dentate gyrus in the hippocampus. Role in depression and cognitive impairment.
Fores-Pons, Ramón; Borroto Escuela, Dasiel Óscar; Pita-Rodríguez, Mariana; Barbancho-Fernández, Miguel Ángel; López-Salas, Alexander; Rosas-Marqués, Paloma; Zamorano-González, Pablo; Fuxe, Kjell; García-Casares, Natalia
; Narváez-Peláez, Manuel
[et al.] (2021-11-05)
Galanin (GAL) interacts with Neuropeptide Y Y1 receptors (NPYY1R) in several regions of the central nervous system associated with mood and motivation, through GAL receptor 2 and NPYY1 receptor 1 (GALR2/NPYY1R) heterodimers. ... -
Galanin and neuropeptide y Y1 receptor agonist coinjection increases newborn cells proliferation on hippocampal dentate gyrus in rats
Narváez-Peláez, Manuel; Borroto Escuela, Dasiel Óscar; Santín-Núñez, Luis Javier
; Fuxe, Kjell (2018-07-13)
The hippocampus is a region in which neurogenesis persists throughout the lifespan in a wide variety of species including humans. Within the dentate gyrus of the hippocampus, the subgranular zone (SGZ) is maintained as a ... -
Galanin decreases NPYY1R internalization and β- Arrestin2 recruitment
Narváez-Peláez, Manuel; Borroto Escuela, Dasiel Óscar; Millón-Peñuela, Carmelo
; Flores-Burgess, Antonio
; Gago-Calderón, Belén
; Santín-Núñez, Luis Javier
; Fuxe, Kjell; Narváez-Bueno, José Ángel
; Díaz-Cabiale, Zaida
[et al.] (2015-10-05)
We have recently described a Galanin receptor 2(GALR2) and Neuropeptide Y Y1 receptor(NPYY1R) interaction at behavioural, cellular and receptor levels through GALR2/NPYY1R heterodimers. The aim of this work was to study ... -
Galanin interacts with Neuropeptide Y Y1 receptor in the dentate gyrus of the hippocampus through GALR2/NPYY1R heterodimers
Narváez-Peláez, Manuel; Borroto Escuela, Dasiel Óscar; Millón-Peñuela, Carmelo
; Flores-Burgess, Antonio
; Gago-Calderón, Belén
; Santín-Núñez, Luis Javier
; Fuxe, Kjell; Narváez-Bueno, José Ángel
; Díaz-Cabiale, Zaida
[et al.] (2016-07-11)
We have shown Galanin(GAL) and Neuropeptide Y Y1(NPYY1) interactions at behavioural, cellular and receptor levels through GALR2/NPYY1R heterodimers in the amygdala. The aim of this work was to analyze GAL/NPYY1R interactions ... -
Galanin n-terminal fragment (1-15) decreases the voluntary alcohol intake in rats
Millón-Peñuela, Carmelo; Flores-Burgess, Antonio
; Castilla-Ortega, María Estela
; Gago-Calderón, Belén
; Serrano, Antonia; Sturla, Antonella; García-Durán, Laura
; Narváez-Bueno, José Ángel
; Fuxe, Kjell; Santín-Núñez, Luis Javier
; Díaz-Cabiale, Zaida
[et al.] (2018-06-28)
Galanin (GAL) is involved in drug abuse and addiction including alcohol intake. In this work, we have analysed the role of the N-terminal GAL fragment (1-15) [GAL(1-15)] in voluntary ethanol consumption in rats using the ... -
Galanin N-Terminal fragment (1-15) enhances the antidepressant effects of the 5-HT1A receptor agonist 8-OH-DPAT in the Forced Swimming Test.
Millón-Peñuela, Carmelo; Flores-Burgess, Antonio
; Narváez-Peláez, Manuel
; Borroto Escuela, Dasiel Óscar; Santín-Núñez, Luis Javier
; Gago-Calderón, Belén
; Parrado-Romero, Concepción
; Gomez de Travecedo, Isabel; Narváez-Bueno, José Ángel
; Fuxe, Kjell; Díaz-Cabiale, Zaida
[et al.] (2016-07-27)
Galanin and Galanin (1-15) [GAL(1-15)] are implicated in anxiety- and depression related behaviors. Moreover, Galanin modulates 5-HT1A receptor (5-HT1AR) function at autorreceptor and postsynaptic level in the brain. In ... -
Galanin N-Terminal fragment (1-15) induces a stronger effect than Galanin in depression- and anxiety- like related behavioural tests in rats.
Millón-Peñuela, Carmelo; Narváez-Peláez, Manuel
; Flores-Burgess, Antonio
; Parrado-Romero, Concepción
; Puigcerver-Martínez, Araceli
; Coveñas, Rafael; Santín-Núñez, Luis Javier
; Borroto Escuela, Dasiel Óscar; Fuxe, Kjell; Narváez-Bueno, José Ángel
; Díaz-Cabiale, Zaida
[et al.] (2014-07-16)
Galanin (GAL) and GAL Receptors are implicated in anxiety- and depression- related behaviours. The GAL N-terminal fragment (1-15) [GAL(1-15)] also induces depressant- and anxiogenic- like actions. In this work, we have ... -
Galanin n-terminal gragment (1-15) modifies the 5-HT1A receptor against [H3]-8-OH-DPAT binding in the dorsal raphe and hippocampus of the rat
Flores-Burgess, Antonio; Millón-Peñuela, Carmelo
; Narváez-Peláez, Manuel
; Barroto-Escuela, Dasiel; Santín-Núñez, Luis Javier
; Gago-Calderón, Belén
; Gomez de Travecedo, Isabel; Narváez-Bueno, José Ángel
; Fuxe, Kjell; Díaz-Cabiale, Zaida
[et al.] (2016-09-09)
We have described that Galanin N-terminal fragment (1-15) [GAL(1-15)] is associated with depressive effects and also modulates the antidepressant effects induced by the 5-HT1A receptor (5-HT1AR) agonist 8-OH-DPAT. The aim ... -
Galanin receptor 2 modifies neuropeptide Y Y1 receptor internalization and β-Arrestin recruitment
Narváez-Peláez, Manuel; Borroto Escuela, Dasiel Óscar; Millón-Peñuela, Carmelo
; Flores-Burgess, Antonio
; Gago-Calderón, Belén
; Santín-Núñez, Luis Javier
; Fuxe, Kjell; Narváez-Bueno, José Ángel
; Díaz-Cabiale, Zaida
[et al.] (2015-10-05)
We have recently described a Galanin receptor 2(GALR2) and Neuropeptide Y Y1 receptor(NPYY1R) interaction at behavioural, cellular and receptor levels through GALR2/NPYY1R heterodimers. The aim of this work was to study ... -
Galanin receptor 2-neuropeptide Y Y1 receptor interactions in the amygdala lead to increased anxiolytic actions
Narváez-Peláez, Manuel; Millón-Peñuela, Carmelo
; Borroto Escuela, Dasiel Óscar; Flores-Burgess, Antonio
; Santín-Núñez, Luis Javier
; Parrado-Romero, Concepción
; Gago-Calderón, Belén
; Puigcerver-Martínez, Araceli
; Fuxe, Kjell; Narváez-Bueno, José Ángel
; Díaz-Cabiale, Zaida
[et al.] (Springer Nature, 2014-05-20)
Galanin (GAL) and Neuropeptide Y (NPY) are neuropeptides involved in behaviors associated with anxiety. Both neuropeptides interact in several central functions. However, the potential behavioral and cellular ...