Listar por autor "García-León, Juan Antonio"
Mostrando ítems 21-31 de 31
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Kinetics and incidence of anti-natalizumab antibodies in multiple sclerosis patients on treatment for 18 months
Oliver-Martos, Begoña
; Fernández Fernández, Óscar; Órpez, Teresa; Alvarenga, Marcos Papais; Pinto-Medel, Mª Jesús; Guerrero, Miguel; León, Antonio; López-Madrona, José Carlos; Maldonado-Sánchez, Rafael; García-León, Juan Antonio; Luque, Gloria; Fernández Sánchez, Victoria Eugenia; Leyva-Fernández, Laura[et al.] (SAGE Journals, 2011)
Natalizumab is a monoclonal antibody shown to be highly effective in the treatment of relapsing–remitting multiple sclerosis (RRMS). Patients treated with natalizumab can develop antibodies directed against this agent that ... -
Kinetics and incidence of anti-natalizumab antibodies in multiple sclerosis patients on treatment for 18 months.
Oliver-Martos, Begoña; Fernández, Óscar; Orpez, Teresa; Alvarenga, Marco Papais; Pinto-Medel, María Jesús; Guerrero, Miguel; León, Antonio; López-Madrona, José Carlos; Maldonado-Sánchez, Rafael; García-León, Juan Antonio; Luque, Gloria; Fernández, Victoria; Leyva-Fernández, Laura[et al.] (SAGE, 2011-03)
Natalizumab is a monoclonal antibody shown to be highly effective in the treatment of relapsing-remitting multiple sclerosis (RRMS). Patients treated with natalizumab can develop antibodies directed against this agent that ... -
Monocyte-derived cells invade brain parenchyma and amyloid plaques in human Alzheimer’s disease hippocampus.
Muñoz-Castro, Clara; Mejías-Ortega, Marina; Sánchez-Mejías, Elisabeth; Navarro, Victoria; Trujillo-Estrada, Laura Isabel; Jimenez, Sebastian; García-León, Juan Antonio; Fernández-Valenzuela, Juan José; Sanchez-Mico, María Virtudes; Romero-Molina, Carmen; Moreno-González, Inés; Baglietto-Vargas, David; Marisa, Vizuete; Gutiérrez-Pérez, Antonia; Vitorica Ferrández, Javier[et al.] (Biomed Central Ltd, 2023-02-28)
Microglia play a major role in the innate immune responses of the CNS and the pathogenesis of Alzheimer’s disease (AD). However, the contribution of nonparenchymal or brain‑infiltrated myeloid cells to disease progression ... -
Neurons and astrocytes derived from human iPSCs to model Alzheimer´s disease
Cáceres Palomo, Laura; Trujillo Estrada, Laura; López Oliva, Elba; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia; García-León, Juan Antonio[et al.] (2023)
Alzheimer's disease (AD) is characterized by presenting a complex pathology, not fully resolved yet. This fact, together with the lack of reliable models, has impeded the development of effective therapies. Recently, several ... -
SOX10 Single Transcription Factor-Based Fast and Efficient Generation of Oligodendrocytes from Human Pluripotent Stem Cells.
García-León, Juan Antonio; Kumar, Manoj; Boon, Ruben; Chau, David; One, Jennifer; Wolfs, Esther; Eggermont, Kristel; Berckmans, Pieter; Gunhanlar, Nilhan; de Vrij, Femke; Lendemeijer, Bas; Pavie, Benjamin; Corthout, Nikky; Kushner, Steven A; Dávila-Cansino, José Carlos; Lambrichts, Ivo; Hu, Wei-Shou; Verfaillie, Catherine M[et al.] (Elsevier, 2018-02)
Scarce access to primary samples and lack of efficient protocols to generate oligodendrocytes (OLs) from human pluripotent stem cells (hPSCs) are hampering our understanding of OL biology and the development of novel ... -
Stem Cell-Derived Oligodendroglial Cells for Therapy in Neurological Diseases.
García-León, Juan Antonio; Verfaillie, Catherine M. (Bentham Science, 2016-07)
There are an important number of neurological diseases where not neurons but glia are the responsible cells for the degeneration of the nervous system. In the last years, determinant roles for oligodendrocytes (OLs) have ... -
Suitability of human-derived cells as a platform for Alzheimer's disease modeling
Cáceres Palomo, Laura; García-León, Juan Antonio; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia (2021)
Aims: Alzheimer's disease (AD) is characterized by presenting a complex pathology, not fully resolved yet. This fact, together with the lack of reliable models, has impeded the development of effective therapies. Recently, ... -
The CD4+ T-cell subset lacking expression of the CD28 costimulatory molecule is expanded and shows a higher activation state in multiple sclerosis.
Pinto-Medel, María Jesús; García-León, Juan Antonio; Oliver-Martos, Begoña; López-Gómez, Carlos; Luque, Gloria; Arnáiz-Urrutia, Carlos; Órpez, Teresa; Marín-Bañasco, Carmen; Fernández Fernández, Óscar; Leyva-Fernández, Laura[et al.] (Elsevier, 2012-01-18)
Multiple sclerosis (MS) is a chronic debilitating disease, in which T-cells are considered to play a pivotal role. CD28 is the quintessential costimulatory molecule on T-cells and its expression declines progressively ... -
TRAIL/TRAIL receptor system and susceptibility to multiple sclerosis
López-Gómez, Carlos; Fernández, Oscar; García-León, Juan Antonio; Pinto-Medel, María Jesús; Oliver-Martos, Begoña; Ortega-Pinazo, Jesús; Suardíaz-García, Margarita; García-Trujillo, Lucía; Guijarro-Castro, Cristina; Benito-León, Julián; Prat, Isidro; Varadé, Jezabel; Alvarez-Lafuente, Roberto; Urcelay, Elena; Leyva-Fernández, Laura[et al.] (Public Library of Science, 2011-07)
The TNF-related apoptosis inducing ligand (TRAIL)/TRAIL receptor system participates in crucial steps in immune cell activation or differentiation. It is able to inhibit proliferation and activation of T cells and to induce ... -
Transgenic Mouse Models of Alzheimer’s Disease: An Integrative Analysis
Sánchez-Varo, Raquel María; Mejías-Ortega, Marina; Fernández-Valenzuela, Juan José; Núñez-Díaz, Cristina; Cáceres Palomo, Laura; Vegas-Gómez, Laura; Sánchez-Mejías, Elisabeth; Trujillo-Estrada, Laura Isabel; Moreno-González, Inés; García-León, Juan Antonio; Vizuete, María Luisa; Vitorica Ferrández, Javier; Baglietto-Vargas, David; Gutiérrez-Pérez, Antonia[et al.] (IOAP-MPDI, 2022-05-12)
Alzheimer’s disease (AD) constitutes the most prominent form of dementia among elderly individuals worldwide. Disease modeling using murine transgenic mice was first initiated thanks to the discovery of heritable mutations ... -
Use of human pluripotent stem cell-derived cells for neurodegenerative disease modeling and drug screening platform
García-León, Juan Antonio; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia (Taylor and Francis, 2019-06)
Most neurodegenerative diseases are characterized by a complex and mostly still unresolved pathology. This fact, together with the lack of reliable disease models, has precluded the development of effective therapies ...