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Listar por autor "Burgos-Molina, Antonio Manuel"
Mostrando ítems 21-40 de 46
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Mechanisms of cross resistance between cisplatin and bleomycin in saccharomyces cerevisiae
Tumor cells can simultaneously acquire resistance against a diverse group of drugs. This phenomenon is called pleotropic resistance or multidrug resistance. This mechanism could explain the tumor resistance observed in ... -
Metabolism is altered in the process of drug resistance acquisition
Burgos-Molina, Antonio Manuel
; Alamilla Presuel, Juan Carlos; González Vidal, Alejandro; Ruiz-Gómez, Miguel José (Aseica, 2022)
Cells need energy to survive, therefore, they increase the different pathways available to obtain it. This suggests that the cell, due to the cytotoxicity of bleomycin, increases the routes to obtain energy. For this reason, ... -
Methods to study the intestinal microbiota to address the disease in a more precise and personalized way
Burgos-Molina, Antonio Manuel; González Vidal, Alejandro; Mercado-Sáenz, Silvia; Alamilla Presuel, Juan Carlos; Ruiz-Gómez, Miguel José (2022)
FISH, clone collection, DGGE, PCR and metagenomics techniques contribute to the study of the human microbiota in a precise and effective way, constituting very useful diagnostic tools in precision medicine to address patient ... -
Microbiota and body axes as a new therapeutic approach in precision medicine
Burgos-Molina, Antonio Manuel; González Vidal, Alejandro; Alamilla Presuel, Juan Carlos; Mercado-Sáenz, Silvia; Ruiz-Gómez, Miguel José (2022)
There is a marked relationship between the composition and diversity of the microbiota and various diseases distant from the intestine. This relationship occurs through different body axes between the intestine and the ... -
Molecular Mechanisms of Resistance to Ionizing Radiation in S. cerevisiae and Its Relationship with Aging, Oxidative Stress, and Antioxidant Activity.
González Vidal, Alejandro; Mercado-Sáenz, Silvia; Burgos-Molina, Antonio Manuel; Alamilla Presuel, Juan Carlos; Alcaraz, Miguel; Sendra-Portero, Francisco; Ruiz-Gómez, Miguel José[et al.] (MDPI, 2023-08-30)
The repair of the damage produced to the genome and proteome by the action of ionizing radiation, oxidizing agents, and during aging is important to maintain cellular homeostasis. Many of the metabolic pathways influence ... -
New markers of bleomycin resistance
Resistance to chemotherapy is one of the main problems of this type of therapy. Studies carried out determine the usefulness of predictive biomarkers to improve this treatment. The aim of this work is to carry out a ... -
One hundred of cells generations connect the resistance to drugs and the replicative aging mechanisms
There are researchs that reveal a relationship between acquired resistance to antineoplastic drugs and aging. Therefore, the identification of genes involved in senescence could have a potential therapeutic utility for ... -
Presence of radon pollution in buildings and risk of cancer
Burgos-Molina, Antonio Manuel; Ruiz González, Óscar M.; González Vidal, Alejandro; Ruiz-Gómez, Miguel José (2022)
Radon gas present in the ground penetrates into homes through different routes, accumulating especially in rooms close to the ground. The dose received from radioactivity due to inhalation of radon inside houses poses a ... -
Proteins involved in carbon metabolism induce bleomycin resistance
Burgos-Molina, Antonio Manuel; Alamilla Presuel, Juan Carlos; Mercado-Sáenz, Silvia; González Vidal, Alejandro; Ruiz González, Óscar M.; Ruiz-Gómez, Miguel José[et al.] (Aseica, 2022)
S. cerevisiae acquires bleomycin resistance after a long-term exposure to this drug which causes overexpression of TPIS protein. It could be involved in the resistance process. For this reason, it could be good candidates ... -
Proteomic analysis in wild type and cisplatin resistant yeast strain of saccharomyces cerevisiae
Research carried out in oncology has allowed the identification and characterization of molecular markers of resistance to antineoplastic drugs. It supposes a great advance and allows the administration of customized ... -
Pulsed magnetic feld increases the efect of ultraviolet C radiation and thermal shock in aged yeasts
Mercado-Sáenz, Silvia; González-Vidal, Alejandro; Burgos-Molina, Antonio Manuel; López-Díaz, Beatriz; Sendra-Portero, Francisco; Ruiz-Gómez, Miguel José[et al.] (Springer, 2023)
The study of the efects of the magnetic feld (MF) on living matter continues to be a dilemma. Until now, the interaction mechanisms of MF with living matter that explain the observed phenomena are unknown. Despite the ... -
Regulation of AURKA, BIRC5 and PLK1 protein expression in colorectal cancer
Burgos-Molina, Antonio Manuel; Rodríguez-García, M.; González-Vidal, A.; Mercado-Sáenz, Silvia; Ruiz-Gómez, Miguel José (ASEICA, 2024-11)
AURKA, BIRC5 and PLK1 proteins show multiple regulatory transcription factors, highlighting E2F7, DRAP1 and ZNF511. The regulation of these protein is important to modulate the progression of cell cycle, cell proliferation, ... -
Relación entre envejecimiento celular y resistencia adquirida a Cisplatino y Bleomicina en Saccharomyces cerevisiae
Burgos-Molina, Antonio Manuel (UMA Editorial, 2017)
El cáncer es la principal causa de muerte en muchos países del mundo En las próximas décadas se convertirá en la principal causa de morbilidad y mortalidad en todas las regiones, indistintamente del nivel de recursos ... -
Relationship between chronological aging and acquired resistance to cisplatin in the yeast saccharomyces cerevisiae
Burgos-Molina, Antonio Manuel; Mercado-Sáenz, Silvia; Gil-Carmona, Luisa; Ruiz-Gómez, Miguel José (2019-01-17)
The Sir2 gene is associated with an increase in longevity in yeasts, worms, flies and rodents. The human homolog, Sirt1, is also involved in longevity, by inhibiting cellular senescence. Studies carry out in tumor cells ... -
Relationship between heat shock proteins and cellular resistance to drugs and ageing
Peinado-Ruiz, Isabel C.; Burgos-Molina, Antonio Manuel; Sendra-Portero, Francisco; Ruiz-Gómez, Miguel José (Elsevier, 2022-10-01)
Background and aims Ageing is a multifactorial degenerative process which causes a decrease in the cellular capacity for repair and adaptation to external stressors. In this way, it is important to maintain the proper ... -
Resistance acquisition after seven cycles of in vitro bleomycin exposure
Burgos-Molina, Antonio Manuel; Gil-Carmona, Luisa; Lumbreras-Vega, Luis Joaquín; Ruiz-Gómez, Miguel José (2019-01-16)
Bleomycin is an antineoplastic drug that causes DNA damage by intra- and inter-strand crosslink and DNA strand breaks. This drug is used to treat several types of cancer. The aim of this work is to study the effect of ... -
Resistance to bleomycin increases the chronological life of cells
Burgos-Molina, Antonio Manuel; Mercado-Sáenz, Silvia; Gil-Carmona, Luisa; Ruiz-Gómez, Miguel José (2019-01-17)
The identification of genes involved in chronological aging could have a potential utility as molecular markers in the chemotherapy treatment of cancer. The aim of this work is to study the relationship between the ... -
Response of normal human cells to stress causing agents and their relationship with ageing and cellular resistance
Burgos-Molina, Antonio Manuel; Peinado-Ruiz, Isabel C.; González Vidal, Alejandro; Ruiz-Gómez, Miguel José (, 2022)
By applying low doses of a stressor, normal cells increase the number of HSP leading to increased survival. This phenomenon is considered a cellular adaptive response. The results show that treatment with low doses of a ... -
Response to radiation in tumor biopsies from colorectal cancer patients.
Burgos-Molina, Antonio Manuel; Rodríguez-García, Marta; González-Vidal, Alejandro; Mercado-Sáenz, Silvia; Ruiz-Gómez, Miguel José (2024)
Analysis of the response to radiation of tumor biopsies can provide very valuable information about the possible resistance of colorectal cancer to treatment. Resistance mechanisms involve overexpression of the CREB-KDM4B-STAT3 ... -
Role of SODC protein in antineoplastic drug resistance
Alamilla Presuel, Juan Carlos; González Vidal, Alejandro; Ruiz González, Óscar M.; Burgos-Molina, Antonio Manuel; Ruiz-Gómez, Miguel José (Aseica, 2022)
Cells need homeostasis to survive, therefore, they use the different pathways available to obtain it. The SODC protein overexpression, which is implicated in this process, suggests that could be implicated in the process ...