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Listar por autor "Torres-Jaén, María Josefa"
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Estudios de la modulación de la respuesta inmunológica y desarrollo de modelos de tolerancia a alérgenos de origen vegetal utilizando nanoestructuras polifuncionales
Rodriguez Sanchez, Maria Jose (UMA Editorial, 2020)La alergia a alimentos es en la actualidad un problema de salud grave, ya que produce reacciones que pueden comprometer la vida del paciente. Su prevalencia va en aumento, llegando a afectar al 3-5% de la población adulta ... -
Expression of the skin-homing receptor in peripheral blood lymphocytes from subjects with nonimmediate cutaneous allergic drug reactions
Blanca, Miguel; Posadas, Sinforiano Jose; Torres-Jaén, María Josefa; Leyva-Fernández, Laura; Mayorga Mayorga, Cristobalina; González, Lourdes; Juárez, Carlos; Fernández, Javier; Santamaría, Luis F[et al.] (Wiley, 2000)Background: In nonimmediate cutaneous reactions to drugs, the skin is the organ most frequently involved, and T lymphocytes may play a relevant role. T cells related to skin immune responses express the cutaneous ... -
Flow-based basophil activation test in immediate drug hypersensitivity. An EAACI task force position paper
Mayorga Mayorga, Cristobalina; Çelik, G.E.; Pascal, M.; Hoffmann, H.J.; Eberlein, B.; Torres-Jaén, María Josefa; Brockow, K.; Garvey, L.H.; Barbaud, A.; Madrigal-Burgaleta, R.; Caubet, J.C.; Ebo, D.G.[et al.] (Wiley, 2023-11-13)Diagnosing immediate drug hypersensitivity reactions (IDHRs) can pose a significant challenge and there is an urgent need for safe and reliable tests. Evidence has emerged that the basophil activation test (BAT), an in ... -
Genomic variants association with selective hypersensitivityreactions to amoxicillin and clavulanic acid
Nuñez, Rafael; Fernández-Santamaría, Rubén; Salas, María; Bogas, Gador; Diez-Echave, Patricia; Mayorga Mayorga, Cristobalina; Torres-Jaén, María Josefa; Fernández-Duarte, Tahía Diana[et al.] (Wiley, 2024-06-29)In summary, there are rare variants found in our patients that could be related to the development of AX or CLV- induced IDHRs. Interestingly, some of these rare variants could be associated with selective response to ... -
In vitro supporting diagnostic tools in plant‐food allergy.
Céspedes Lagos, José Antonio; Lebrón-Martín, Clara; García-Otón, Reyes; Delgado, María Jesús; Martín Astorga, María del Carmen; Pérez-Sánchez, Natalia Isabel; Gómez, Francisca; Torres-Jaén, María Josefa; Cañas, José Antonio; Aranda, Carlos José; Mayorga Mayorga, Cristobalina[et al.] (Wiley, 2023-04-06) -
In vitro T-cell responses to beta-lactam drugs in immediate and nonimmediate allergic reactions.
Luque, Inmaculada; Leyva-Fernández, Laura; Torres-Jaén, María Josefa; Rosal, Manuel; Mayorga Mayorga, Cristobalina; Segura, José Manuel; Blanca, Miguel; Juárez, Carlos[et al.] (Wiley, 2008)Background: Beta-Lactam drugs may induce both cellular and humoral allergic reactions, and there is evidence that T cells play an important role in the pathogenesis of these reactions. The aim of this work was to assess ... -
Influence of pore size in protein G'-grafted mesoporous silica nanoparticles as a serum pretreatment system for in vitro allergy diagnosis
Paris, Juan Luis; Monío, Cristina; Pérez-Moreno, Ana M.; Jurado-Escobar, Raquel; Bogas Herrera, Gádor; Fernández-Duarte, Tahía Diana; Montañez-Vega, María Isabel; Mayorga Mayorga, Cristobalina; Torres-Jaén, María Josefa[et al.] (Wiley, 2023)Particles with the capacity to bind to immunoglobulin G (IgG) can be used for the purification of IgG or to process clinical samples for diagnostic purposes. For in vitro allergy diagnosis, the high IgG levels in serum can ... -
LPS in combination with amoxicillin increases BAT sensitivity to amoxicillin IgE‐mediated hypersensitivity
Céspedes Lagos, José Antonio; Fernández-Santamaría, Rubén; Bogas Herrera, Gádor; Ariza Veguillas, Adriana; Doña, Inmaculada; Salas, María; Labella, Marina; Fernández-Duarte, Tahía Diana; Mayorga Mayorga, Cristobalina; Torres-Jaén, María Josefa; Frecha, Cecilia[et al.] (Wiley, 2024)β-lactams (BLs), and among them, amoxicillin (AX) are the most current prescribed antibiotics to treat bacterial infections,1 and their use is related to an increasing prevalence of drug hypersensitivity reactions (DHRs),2 ... -
Medical algorithm: Diagnosis and treatment of nonsteroidal antiinflammatory drugs hypersensitivity
Doña, Inmaculada; Pérez-Sánchez, Natalia; Bogas, Gador; Moreno, Esther; Salas, María; Torres-Jaén, María Josefa[et al.] (Wiley, 2020)Diagnosis in suspected hypersensitivity reactions to nonsteroidal anti-inflammatory drugs (NSAIDs) is complex as different mechanisms are involved: specific (selective responders, SRs) and nonspecific immunologically ... -
New approaches for Basophil Activation Tests employing Dendrimeric Antigen-Silica Nanoparticle composites.
Calvo-Serrano, Silvia; Matamoros, Esther; Céspedes, José Antonio; Fernández-Santamaría, Rubén; Gil-Ocaña, Violeta; Pérez-Inestrosa, Ezequiel; Frecha, Cecilia; Montañez-Vega, María Isabel; Vida-Pol, Yolanda; Mayorga Mayorga, Cristobalina; Torres-Jaén, María Josefa[et al.] (MDPI, 2024-08-03)In vitro detection of specific IgE bound to high-affinity receptor on basophils’ surface is 25 a widely used strategy for the evaluation of IgE-mediated immediate hypersensitivity reactions to 26 drugs. Due to the drug ... -
New Approaches in the Manufacture of Biomaterials for Betalactam Allergic Diagnose
Collado-Martín, Daniel; Pérez-de-Inestrosa-Villatoro, Ezequiel; Ruiz-Sanchez, Antonio Jesus; Mayorga Mayorga, Cristobalina; Torres-Jaén, María Josefa (2019-09-11)Betalactams are the most widely utilized drugs against infections but are the primary cause of allergic reactions to antibiotic drugs. REF1 An accurate diagnosis of these allergic reactions to betalactams is crucial to ... -
Organ-specific allergen challenges in airway allergy: Current utilities and future directions
Fauquert, J. L.; Alba-Linero, Carmen; Gherasim, A.; Testera Montes, A.; Bentabol-Ramos, G.; Saenz de Santa María-García, Rocío; Torres-Jaén, María Josefa; Eguiluz-Gracia, Ibón; Rondon, C.[et al.] (Wiley, 2023)Atopy has been long used as the screening method for airway allergy. Nevertheless, aeroallergens can trigger respiratory symptoms not only in atopic patients (atopic res piratory allergy, ARA), but also in non-atopic ... -
Perfil de sensibilización en pacientes con alergia a melocotón, y estudio de los cambios inmunológicos, eficacia y tolerancia a inmunoterapia específica con melocotón
Bogas Herrera, Gádor (UMA Editorial, 2016)Aproximadamente el 2% de la población adulta es alérgica a alimentos, fundamentalmente a vegetales, siendo la familia de las Rosaceae la más frecuentemente implicada (1,2,3,4,5,6,7). La alergia a alimentos tiene un gran ... -
Resensitization in suspected penicillin allergy
Doña, Inmaculada; Guidolin, Lucia; Bogas Herrera, Gádor; Olivieri, Elisa; Labella, Marina; Schiapolli, Michele; Saenz de Santa María-García, Rocío; Dama, Annarita; Salas, María; Senna, Gianenrico; Bonadonna, Patrizia; Torres-Jaén, María Josefa[et al.] (Wiley, 2022-09-06)The diagnosis of allergic reactions to penicillins (AR-PEN) is very complex as there is a loss of sensitization over time, which leads to negative skin tests (STs) and specific IgE in serum, and even to tolerance to the ... -
Role of minor determinants of amoxicillin in the diagnosis of immediate allergic reactions to amoxicillin.
Background: Skin testing of subjects with immediate hypersensitivity to amoxicillin is performed using major and minor determinants of benzylpenicillin plus amoxicillin. However, sensitivity is not optimal, and other ... -
Silica Particle based nanocomposites for Specific IgE Determination to Betalactams
Matamoros Castellano, Esther; Gil-Ocaña, Violeta; Jiménez, Isabel M.; Mayorga Mayorga, Cristobalina; Doña, Inmaculada; Céspedes Lagos, José Antonio; Montañez-Vega, María Isabel; Vida-Pol, Yolanda; Pérez-de-Inestrosa-Villatoro, Ezequiel; Torres-Jaén, María Josefa[et al.] (2023)Current immunoassays for diagnosing betalactam (BL) allergy have limited sensitivity and poor specificity. These include ImmunoCAP, the commercial immunoassay, and the radioallergosorbent test (RAST), a handmade test ... -
Subjects with allergic reactions to drugs show in vivo polarized patterns of cytokine expression depending on the chronology of the clinical reaction
Posadas, Sinforiano Jose; Leyva-Fernández, Laura; Torres-Jaén, María Josefa; Rodríguez-Bada, José Luis; Bravo, Inmaculada; Rosal, Manuel; Fernández, Javier; Juárez, Carlos; Blanca, Miguel[et al.] (Elsevier, 2000-10)Background: The mechanisms involved in adverse drug reactions with an immunologic basis (ADRIB) can be antibody dependent, mainly IgE or T cell dependent (sensitized T cells). These mechanisms are regulated by a number of ... -
Synthesis of fluorescent dendrimeric antigen efficiently internalized by human dendritic cells
Mesa-Antunez, Pablo; Collado-Martín, Daniel; Vida-Pol, Yolanda; Nájera-Albendín, Francisco; Fernández-Duarte, Tahía Diana; Torres-Jaén, María Josefa; Pérez-de-Inestrosa-Villatoro, Ezequiel[et al.] (Servicio de Publicaciones de la Universidad de Huelva, 2016)A new fluorescent dendrimeric antigen (DeAn) based on a dendron with amoxicilloyl terminal groups has been synthetized. The synthesis implies a novel class of all-aliphatic polyamide dendrimer (BisAminoalkylPolyAmide ... -
The value of the basophil activation test in the evaluation of patients reporting allergic reactions to the BNT162b2 mRNA COVID-19 vaccine
Labella, Marina; Céspedes Lagos, José Antonio; Doña, Inmaculada; Shamji, Mohamed H.; Agache, Ioana; Mayorga Mayorga, Cristobalina; Torres-Jaén, María Josefa[et al.] (Wiley, 2021-10-24) -
Transcriptional profiling of dendritic cells in a mouse model of food-antigen induced anaphylaxis reveals the upregulation of multiple immune-related pathways.
Rodríguez, María José; Palomares, Francisca; Bogas, Gador; Torres-Jaén, María Josefa; Díaz-Perales, Araceli; Rojo, Javier; Plaza Serón, María del Carmen; Rodríguez-Nogales, Alba; Orengo, Christine A.; Mayorga, Cristobalina; Perkins, James Richard[et al.] (Wiley, 2018-10-20)Scope Much of our knowledge about gene expression during anaphylaxis comes from candidate gene studies. Despite their potential role, expression changes in dendritic cells (DCs) have not been studied in this context using ...