Listar por autor "Santos-Ruiz, Leonor"
Mostrando ítems 1-20 de 27
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3D Biomimetic Porous Titanium (Ti6Al4V ELI) Scaffolds for Large Bone Critical Defect Reconstruction: An Experimental Study in Sheep
Crovace, Alberto Maria; Lacitignola, Luca; Monopoli Forleo, Donato; Staffieri, Francesco; Francioso, Edda; Di Meo, Antonio; Becerra-Ratia, José
; Crovace, Antonio; Santos-Ruiz, Leonor[et al.] (MDPI, 2020-08-11)
The main goal in the treatment of large bone defects is to guarantee a rapid loading of the affected limb. In this paper, the authors proposed a new reconstructive technique that proved to be suitable to reach this purpose ... -
41 Cases of Treatment of Cranial Cruciate Ligament Rupture with Porous TTA: Three Years of Follow Up
Trisciuzzi, Rodrigo; Fracassi, Laura; Afonso Martín, Hernando; Monopoli Forleo, Donato; Amat, Daniel; Santos-Ruiz, Leonor; De Palma, Elena; Crovace, Alberto Maria[et al.] (MDPI, 2019-02-20)
Tibial Tuberosity Advancement (TTA) is a surgical technique based on a linear osteotomy that determines a cranial advancement of the tibial tuberosity in patients suffering from cranial cruciate ligament rupture (CCL). The ... -
A collagen-targeted biomimetic RGD peptide to promote osteogenesis
Visser, Rick; Arrabal-García, Pilar María; Santos-Ruiz, Leonor; Fernández-Barranco, Raúl; Becerra-Ratia, José; Cifuentes-Rueda, Manuel[et al.] (MARY ANN LIEBERT, INC, 2014-01)
Osteogenesis is a complex, multifactorial process in which many different signals interact. The bone morphogenetic proteins (BMPs) are the most potent inducers of osteoblastic differentiation, although very high doses of ... -
A model of maxilla resection to test new hybrid implants:macroporous titanium and tissue engineering elements
Santos-Ruiz, Leonor; Monopoli, Donato; Yáñez Vilas, José Ignacio; Mentado, Belinda; Ruiz, F; Argárate, N; Granados, F; Arrabal-García, Pilar María; Belmonte, Rosa María; Becerra-Ratia, José[et al.] (2015-07-23)
Maxillary bone loss in commonly found in humans, due to bone ageing, tooth loos, periodontal disease and, more severely, to trauma, radiotherapy and tumor resection. Masillofacial reconstructive surgery is a still unmet ... -
A synthetic collagen-binding arg-gly-asp (rgd) biomimetic peptide enhances bone cell differentiation
Visser, Rick; Arrabal-García, Pilar María; Santos-Ruiz, Leonor; Fernández-Barranco, Raúl; Cifuentes-Rueda, Manuel; Becerra-Ratia, José[et al.] (2013-11-27)
RGD (arginine-glycine-aspartic acid) peptides have shown some promising abilities to promote the attachment of cells to biomaterials and to direct their differentiation. However, anchoring these peptides to the biomaterial’s ... -
Basic fibroblast growth factor enhances the osteogenic differentiation induced by bone morphogenetic protein-6 in vitro and in vivo
Visser, Rick; Arrabal-García, Pilar María; Santos-Ruiz, Leonor; Becerra-Ratia, José; Cifuentes-Rueda, Manuel (ELSEVIER, 2012-04)
Some members of the bone morphogenetic protein subfamily (BMP-2 and -7) are currently used in orthopedic surgery for several applications. Although their use is considered safe at short term, the high doses of growth factors ... -
Behavior of osteoprogenitor cells on EBM-sintered Ti6Al4V-scaffolds coated RGD-presenting hemidendrons. Implications for prosthesis design
González, Ana; Cabeza, Noemí; Vida-Pol, Yolanda; Pérez-de-Inestrosa-Villatoro, Ezequiel; Santos-Ruiz, Leonor; Becerra-Ratia, José; Monopoli, Donato[et al.] (2017-12-12)
Titanium-based prosthetic implants are commonly used in Traumatology and Maxillofacial Surgery to achieve functional recovery of a severely damaged bones. Prosthetic replacements fail in the long term due to poor ... -
Bone marrow-derived mesenchymal stem cells characterization and transplantation in an animal model of congenital hydrocephalus
García-Bonilla, María; Cifuentes-Rueda, Manuel; Ho-Plágaro, Ailec; Santos-Ruiz, Leonor; Shumilov, Kirill; Pérez-Fígares, José Manuel; Jiménez-Lara, Antonio Jesús[et al.] (2015-10-08)
Congenital hydrocephalus is a disorder presenting a degeneration of the periventricular cerebral parenchyma and the white matter, which causes significant mortality and life-long neurological complications. There are ... -
Células madre : ¿la panacea de la medicina del siglo XXI?
Santos-Ruiz, Leonor (UMA / SEDOC, 2010)
Hemos oído hablar mucho de ellas últimamente. Muchos han puesto en ella su esperanza. Las hay embrionarias, adultas, inducidas e incluso híbridas. Pero ¿qué son y para qué pueden servir este tipo de células? -
Characterization and administration of bone marrow-derived mesenchymal stem cells in an animal model of congenital hydrocephalus
García-Bonilla, María; Cifuentes-Rueda, Manuel; Ho-Plágaro, Ailec; Shumilov, Kirill; Santos-Ruiz, Leonor; Pérez-Fígares, José Manuel; Jiménez-Lara, Antonio Jesús[et al.] (2015-07-08)
Bone marrow-derived mesenchymal stem cells (BM-MSC) are considered as a potential therapeutic tool in neurodegenerative diseases, due to their ability to migrate to degenerated tissues and the production of growth factors. ... -
Combining tissue engineering with metal scaffolds in orthopaedic to improve osseointegration of endoprothesis
Electron Beam Melting (EBM) technology allows the fabrication of free-formed metal scaffolds, thus creating the possibility of manufacturing patient-specific endo-prostheses. It also allows the production of highly-porous ... -
Dendritic scaffold onto titanium implants. A versatile strategy increasing biocompatibility.
Molina, Noemí; González, Ana; Monopoli, Donato; Mentado, Belinda; Becerra-Ratia, José; Santos-Ruiz, Leonor; Vida-Pol, Yolanda; Pérez-Inestrosa, Ezequiel[et al.] (MDPI, 2020-04-01)
Osseointegration of metal prosthetic implants is a yet unresolved clinical need that depends on the interplay between the implant surface and bone cells. The lack of a relationship between bone cells and metal has traditionally ... -
Desarrollo de implantes protesicos personalizados mediante impresión 3D de metales para el tratamiento quirúrgico de defectos maxilares
Santos-Ruiz, Leonor; Ruiz Delgado, Francisco; Yáñez Vilas, José Ignacio; Granados Colocho, Juan Francisco; Monopoli, Donato; Rodríguez Acosta, Antonio Andrés[et al.] (2022)
La osteonecrosis mandibular es una patología que suele presentarse como efecto secundario de la radioterapia con que se tratan los procesos oncológicos de cabeza y cuello, o después de tratamientos prolongados con bifosfonatos. ... -
Evaluación del potencial biomédico de nuevos biomateriales para aplicación en cirugía ortopédica y traumatología
(Universidad de Málaga, Servicio de Publicaciones y Divulgación Científica, 2014)Las situaciones clínicas relacionadas con fracturas de hueso complejas, tales como fracturas no consolidadas o fracturas patológicas, demandan cada vez más el desarrollo de materiales terapéuticos con la capacidad para ... -
Hábitos de lectura en estudiantes de Educación Secundaria
Santos-Ruiz, Leonor (2016-12-19)
Las actuales leyes educativas autonómicas y estatales conceden a la comprensión lectora un carácter transversal que otorga calidad en la enseñanza (Ley Orgánica 8/2013, de 9 de diciembre, para la mejora de la calidad ... -
In Vitro Induction of Tendon-Specific Markers in Tendon Cells, Adipose- and Bone Marrow-Derived Stem Cells is Dependent on TGF3, BMP-12 and Ascorbic Acid Stimulation
Perucca Orfei, Carlotta; Viganò, Marco; Pearson, John R.; Colombini, A.; De Luca, P.; Ragni, E.; Santos-Ruiz, Leonor; De Girolamo, Laura[et al.] (MDPI, 2019-01-01)
Mesenchymal Stem Cells (MSCs) and tissue-specific progenitors have been proposed as useful tools for regenerative medicine approaches in bone, cartilage and tendon-related pathologies. The differentiation of cells towards ... -
In vitro stimulation of MC3T3-E1cells and sustained drug delivery by a hierarchical nanostructured SiO2-CaO-P2O5 scaffold
Ramiro-Gutiérrez, María Lourdes; Santos-Ruiz, Leonor; Borrego-González, Sara; Becerra-Ratia, José; Díaz-Cuenca, Aránzazu (Elsevier, 2016-07-15)
A hierarchical scaffold, SP1_h_HA, consisting of a biomimetic nano-hydroxyapatite surface coating growth onto a reticulated structure having a nano-organized porous texture was fabricated and functionally studied in vitro ... -
Neocortical tissue recovery in severe congenital obstructive hydrocephalus after intraventricular administration of bone marrow-derived mesenchymal stem cells.
García-Bonilla, María; Ojeda-Pérez, Betsaida; García-Martín, María Luisa; Muñoz-Hernández, María del Carmen; Vitorica, Javier; Jiménez, Sebastián; Cifuentes-Rueda, Manuel; Santos-Ruiz, Leonor; Shumilov, Kirill; Claros-Gil, Silvia; Gutiérrez-Pérez, Antonia; Páez-González, Patricia[et al.] (BMC, 2020-03-17)
In obstructive congenital hydrocephalus, cerebrospinal fluid accumulation is associated with high intracranial pressure and the presence of periventricular edema, ischemia/hypoxia, damage of the white matter, and glial ... -
Novel approaches for osteosarcoma treatment: drug combination, nanotechnology and cell therapy
(UMA Editorial, 2023-03-03)Osteosarcoma is one of the most common malignant tumours of bone, primarily affecting children and adolescents. Although the implementation of chemotherapy and radiotherapy has substantially improved survival of patients ... -
On the potential of decidua-derived MSC as therapeutic agents for bone repair
Belmonte, Rosa María; Flores, Ana Isabel; Amat Trujillo, Daniel; González-Luque, Ana; Becerra-Ratia, José; Santos-Ruiz, Leonor[et al.] (2016-10-25)
OBJECTIVE: Adult mesenchymal stem cells derived from fat or bone marrow represent a promising therapeutic treatment to promote tissue regeneration. However, their availability is limited by the number of donors who are ...