Listar por autor "Pavía-Molina, José"
Mostrando ítems 1-20 de 23
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Antioxidant and neuroprotective actions of IGF-II against glucocorticoid-induced toxicity in dopaminergic neurons.
Claros-Gil, Silvia
; Valverde Moreno, Nadia; Zamorano-González, Pablo; Romero-Zerbo, Silvana Yanina; Lara Fernández, Estrella; Boraldi, Federica; Pavía-Molina, José; García-Fernández, María Inmaculada; Gago-Calderón, Belén; Martín-Montañez, Elisa[et al.] (2023)
The neurodegenerative Parkinson’s disease (PD) affects 1–3% of the population aged over 65. A wide range of pathways and mechanisms are involved in its pathogenesis, such as oxidative stress, mitochondrial dysfunction, ... -
Antiviral, Immunomodulatory and Antiproliferative Activities of Recombinant Soluble IFNAR2 without IFN-ß Mediation
Hurtado-Guerrero, Isaac; Hernáez, Bruno; Pinto-Medel, Maria Jesús; Calonge, Esther; Rodríguez-Bada, José Luis; Urbaneja, Patricia; Alonso, Ana; Mena-Vázquez, Natalia; Aliaga, Pablo; Issazadeh-Navikas, Shohreh; Pavía-Molina, José; Leyva-Fernández, Laura; Alcamí, José; Alcamí, Antonio; Fernández-Fernández, Óscar; Oliver-Martos, Begoña[et al.] (MDPI, 2020)
Soluble receptors of cytokines are able to modify cytokine activities and therefore the immune system, and some have intrinsic biological activities without mediation from their cytokines. The soluble interferon beta (IFN-ß) ... -
Decreased soluble IFN-β receptor (sIFNAR2) in multiple sclerosis patients: A potential serum diagnostic biomarker
Órpez-Zafra, Teresa; Pavía-Molina, José; Hurtado-Guerrero, Isaac; Pinto-Medel, Maria Jesús; Rodríguez-Bada, José Luis; Urbaneja, Patricia; Suardíaz García, Margarita; Villar, Luisa M; Comabella, Manuel; Montalban, Xavier; Alvarez-Cermeño, Jose C; Leyva-Fernández, Laura; Fernández-Fernández, Óscar; Oliver-Martos, Begoña[et al.] (SAGE Journals, 2017)
Background: The soluble isoform of the interferon-β (IFN-β) receptor (sIFNAR2) could modulate the activity of both endogenous and systemically administered IFN-β. Previously, we described lower serum sIFNAR2 levels in ... -
Development and validation of an ELISA for quantification of soluble IFN-β receptor: assessment in multiple sclerosis
Órpez-Zafra, Teresa; Pavía-Molina, José; Pinto-Medel, Maria Jesús; Hurtado-Guerrero, Isaac; Rodríguez-Bada, José Luis; Martín-Montañez, Elisa; Fernández Fernández, Óscar; Leyva-Fernández, Laura; Oliver-Martos, Begoña[et al.] (Taylor & Francis, 2015)
Aim: The soluble isoform of the IFN-β receptor (sIFNAR2) can bind IFN-β and modulate its activity, although its role in autoimmune diseases remains unknown. Methods: A recombinant human sIFNAR2 protein was cloned, ... -
Efecto neuroprotector de fingolimod fosfato sobre el estrés oxidativo y el daño mitocondrial inducido por menadiona en neuronas dopaminérgicas en cultivo
(UMA Editorial, 2022)Las enfermedades neurodegenerativas se caracterizan por un desequilibrio en el estado oxidativo neuronal junto con un daño mitocondrial, limitando la producción de energía necesaria para realizar sus funciones neuronales. ... -
Efecto neuroprotector de IGF-II en situaciones de estrés neuronal inducido por corticosterona
Aguirre-Gómez, José Ángel; Martinez-Montañez, Elisa; Pavía-Molina, José; Santín-Núñez, Luis Javier; Estivill-Torrús, Guillermo; García-Fernández, María Inmaculada[et al.] (2013-10-02)
El daño por estrés en tejido neuronal mediado por la presencia de elevados niveles de corticosterona, se relaciona con la producción de alteraciones en funciones cognitivas. Así, el estrés agudo induce un aumento importante ... -
Fingolimod phosphate protection against mitochondrial damage in neuronal cells
Martín-Montañez, Elisa; Gil Cebrián, Antonio Jesús; Valverde, Nadia; Lara, Estrella; De Luque, Vanessa; Boraldi, Federica; Urbano, María; García-Fernández, María Inmaculada; Pavía-Molina, José[et al.] (Elsevier, 2019-04-17)
Background: Major role of oxidative stress in the pathogenesis of neurodegenerative diseases have been suggested, being mitochondria one of the main sources of ROS. Aim: In the present work, we have studied the antioxidant ... -
Graphene derivative scaffolds facilitate in vitro cell survival and maturation of dopaminergic SN4741 cells
Rodríguez-Losada, Noela; Wendelbo, Rune; García-Fernández, María Inmaculada; Pavía-Molina, José; Martinez-Montañez, Elisa; Lara-Muñoz, José Pablo; Arenas, Ernest; Aguirre-Gómez, José Ángel[et al.] (2014-11-26)
The emerging carbon nanomaterial Graphene (G), in the form of scaffold structure, has an efficient bioconjugation with common biomolecules and activates cell differentiation of neuronal stem cells, providing a promising ... -
Graphene derivatives as scaffold for ex vivo survival and maturation of dopaminergic SN4741 cells.
Rodríguez-Losada, Noela; Wendelbo, Rune; García-Fernández, María Inmaculada; Pavía-Molina, José; Martín-Montañez, Elisa; Lara-Muñoz, José Pablo; Arenas, Ernest; Aguirre-Gómez, José Ángel[et al.] (2014-09-01)
Carbon nanomaterial Graphene (G) can form a three-dimensional porous structure with efficient bioconjugation and cell differentiation properties, providing a promising scaffold for neural regeneration. Aims: To study this ... -
Helitransporte medicalizado: Situación actual en España y análisis de los últimos doce años de actividad en Andalucía
(Servicio de Publicaciones y Divulgación Científica, 2016)INTRODUCCIÓN • Los servicios de emergencia médica con helicópteros, en adelante HEMS (Helicopter Emergency Medical Service) son una herramienta consolidada en la asistencia sanitaria extra-hospitalaria y un componente ... -
IGF-II as a neuroprotective and neuroplastic factor in an oxidative damage model induced by glucocorticoids
Lara Fernández, Estrella; Valverde, Nadia; De Luque, Vanessa; Boraldi, Federica; Santín-Núñez, Luis Javier; Pavía-Molina, José; Martín-Montañez, Elisa; García-Fernández, María Inmaculada[et al.] (2018-10-11)
IGF-II is a pleiotropic hormone widely distributed in the CNS, which triggers its functions by binding to IGF-IR, InsulinR and IGFII / M6P (IGF-IIR) receptors. Recently, it has been proposed that the effects of IGF-II, ... -
IGF-II treatment prevents the oxidative damage derived by MPP+/MPTP administration in a cellular and animal model of Parkinson’s disease.
Zamorano-González, Pablo; Valverde, Nadia; Claros-Gil, Silvia; López-González, Manuel Víctor; Romero-Zerbo, Silvana Yanina; Lara, Estrella; Boraldi, Federica; Pavía-Molina, José; García-Fernández, María Inmaculada; Gago-Calderón, Belén; Martín-Montañez, Elisa[et al.] (2023)
El factor de crecimiento de la insulina-II (IGF-II) ha mostrado efectos antioxidantes y neuroprotectores en algunos trastornos neurodegenerativos, como es la Enfermedad de Parkinson (EP). Analizamos el efecto de IGF-II ... -
Impacto del aprendizaje-servicio en el estudiantado de Farmacología General en la Universidad de Málaga
Cabello-Porras, María Rosario; Pavía-Molina, José; Leyva-Fernández, Laura; Martín-Montañez, Elisa (Comité organizador XI congreso nacional y V internacional de Aprendizaje-Servicio Universitario, 2023-01-25)
Proyecto de Aprendizaje-Servicio (ApS) en la asignatura obligatoria General Pharmacology del grado en Medicina con la Asociación de Familiares de Enfermos de Alzheimer-Mijas. Se revisaron fichas de tratamiento de pacientes, ... -
Improving oral presentation skills for radiology residents through clinical session meetings in the virtual world Second Life
Pino-Postigo, Alberto; Domínguez-Pinos, Dolores; Lorenzo Álvarez, Rocío; Pavía-Molina, José; Ruiz-Gómez, Miguel José; Sendra-Portero, Francisco[et al.] (MDPI, 2023-03-08)
Background: The objective of this study was to conduct a clinical session meeting in the virtual world of Second Life to improve the oral presentation skills of radiology residents and to assess the perception of the ... -
Insulin-like growth factor II neuroprotective effects against mitochondrial-oxidative and neuronal damage induced by CORT and MPP+ in dopaminergic neurons
Claros-Gil, Silvia; Cabrera García, Pablo; Valverde, Nadia; Romero-Zerbo, Silvana Yanina; Lara, Estrella; López-González, Manuel Víctor; Shumilov, Kirill; Rivera-Ramírez, Alicia; Pavía-Molina, José; Martín-Montañez, Elisa; García-Fernández, María Inmaculada[et al.] (2022-07-12)
Aims: Parkinson’s disease (PD) affects 1–3% of the population aged over 65. Stress seems to contribute to PD neuropathology, probably by dysregulation of the hypothalamic–pituitary–adrenal axis. Key factors are oxidative ... -
Insulin-like Growth Factor II Prevents MPP+ and Glucocorticoid Mitochondrial-Oxidative and Neuronal Damage in Dopaminergic Neurons
Claros-Gil, Silvia; Cabrera, Pablo; Valverde, María; Romero-Zerbo, Silvana Yanina; López-González, Manuel Víctor; Shumilov, Kirill; Rivera-Ramírez, Alicia; Pavía-Molina, José; Martín-Montañez, Elisa; García-Fernández, María Inmaculada[et al.] (MDPI, 2021-12-24)
Stress seems to contribute to Parkinson’s disease (PD) neuropathology, probably by dysregulation of the hypothalamic–pituitary–adrenal axis. Key factors in this pathophysiology are oxidative stress and mitochondrial ... -
Manejo de la anemia en el puerperio tras cesárea
(UMA Editorial, 2017-06-05)Según la Organización Mundial de la Salud (OMS) la anemia se define como valores de Hb menores de 12 g/dl en mujeres y de 13 g/dl en hombres (1). La anemia en el post-parto (APP) es una situación especial, y como tal tiene ... -
Neuroprotective effects of insulin-like growth factor II in a mouse model of Parkinson's disease
Ladrón de Guevara-Miranda, David; Martín-Montañez, Elisa; Valverde, Nadia; Lara, Estrella; Romero-Zerbo, Silvana Yanina; Millón-Peñuela, Carmelo; Boraldi, Federica; Ávila-Gámiz, Fabiola; Pérez-Cano, Ana María; Garrido-Gil, Pablo; Labandeira-García, José Luis; Santín-Núñez, Luis Javier; Pavía-Molina, José; García-Fernández, María Inmaculada[et al.] (2022-07-20)
Progressive degeneration of the nigrostriatal dopaminergic pathway is a core, currently irreversible pathological hallmark of Parkinson’s disease (PD) that leads to a variety of motor and non-motor symptoms. Here, we aimed ... -
New molecular mechanisms to explain the neuroprotective effects of insulin-like growth factor II in a cellular model of Parkinson's disease
Romero-Zerbo, Silvana Yanina; Valverde, Nadia; Claros-Gil, Silvia; Zamorano-González, Pablo; Boraldi, Federica; Lofaro, Francesco-Demetrio; Lara, Estrella; Pavía-Molina, José; García-Fernández, María Inmaculada; Gago-Calderón, Belén; Martín-Montañez, Elisa[et al.] (Elsevier, 2024-02-08)
Introduction One of the hallmarks of Parkinsońs Disease (PD) is oxidative distress, leading to mitochondrial dysfunction and neurodegeneration. Insulin-like growth factor II (IGF-II) has been proven to have antioxidant ... -
Papel del receptor S1P sobre el estrés oxidativo mitocondrial en cultivo neuronal
Valverde, Nadia; Lara, Estrella; Gil Cebrián, Antonio Jesús; De Luque, Vanessa; Boraldi, Federica; Pavía-Molina, José; Fernández, Oscar; Martín-Montañez, Elisa; García-Fernández, María Inmaculada[et al.] (2019-06-25)
Introducción: Fingolimod, fármaco inmunomodulador, presenta propiedades neuroprotectoras que podrían promover la recuperación de la función cognitiva en enfermedades neurodegenerativas. El estrés oxidativo parece tener un ...