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Listar por autor "Aguilella, Vicente M"
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Role of severe acute respiratory syndrome Coronavirus Viroporins E, 3a, and 8a in replication and pathogenesis
Castaño-Rodriguez, Carlos; Honrubia, José M.; Gutiérrez-Álvarez, Javier; DeDiego, Marta L.; Nieto-Torres, Jose Luis; Jimenez-Guardeño, Jose Manuel; Regla-Nava, Jose Angel; Fernandez-Delgado, Raul; Verdiá-Báguena, Carmina; Queralt-Martín, María; Kochan, Grazyna; Perlman, Stanley; Aguilella, Vicente M; Sola, Isabel; Enjuanes, Luis[et al.] (American Society for Microbiology, 2018)Viroporins are viral proteins with ion channel (IC) activity that play an important role in several processes, including virus replication and pathogenesis. While many coronaviruses (CoVs) encode two viroporins, severe ... -
Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome
Nieto-Torres, Jose Luis; Verdiá-Báguena, Carmina; Jimenez-Guardeño, Jose Manuel; Regla-Nava, Jose Angel; Castaño-Rodriguez, Carlos; Fernandez-Delgado, Raul; Torres, Jaume; Aguilella, Vicente M; Enjuanes, Luis[et al.] (Elsevier, 2015)Severe acute respiratory syndrome coronavirus (SARS-CoV) envelope (E) protein is a viroporin involved in virulence. E protein ion channel (IC) activity is specifically correlated with enhanced pulmonary damage, edema ... -
Severe acute respiratory syndrome coronavirus envelope protein ion channel activity promotes virus fitness and pathogenesis
Nieto-Torres, Jose Luis; DeDiego, Marta L.; Verdiá-Báguena, Carmina; Jimenez-Guardeño, Jose Manuel; Regla-Nava, Jose Angel; Fernandez-Delgado, Raul; Castaño-Rodriguez, Carlos; Alcaraz, Antonio; Torres, Jaume; Aguilella, Vicente M; Enjuanes, Luis[et al.] (2014)Deletion of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) envelope (E) gene attenuates the virus. E gene encodes a small multifunctional protein that possesses ion channel (IC) activity, an important function ...