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Can a minimal replicating construct be identified as the embodiment of cancer?
Solé, Ricard V.; Valverde, Sergi; Rodríguez-Caso, Carlos Francisco; Sardanyés, Josep (Wiley, 2014-04)
Genomic instability is a hallmark of cancer. Cancer cells that exhibit abnormal chromosomes are characteristic of most advanced tumours, despite the potential threat represented by accumulated genetic damage. Carcinogenesis ... -
Coexistence of nestedness and modularity in host–pathogen infection networks.
Valverde, Sergi; Vidiella, Blai; Montañez, Raúl; Fraile, Aurora; Sacristán, Soledad; García-Arenal, Fernando[et al.] (Springer Nature, 2020)The long-term coevolution of hosts and pathogens in their environment forms a complex web of multi-scale interactions. Understanding how environmental heterogeneity affects the structure of host–pathogen networks is a ... -
Emergence of proto-organisms from bistable stochastic differentiation and adhesion.
Durán-Nebreda, Salva; Bonforti, Adriano; Montañez, Raúl; Valverde, Sergi; Solé, Ricard V. (The Royal Society, 2016-04-13)The rise of multicellularity in the early evolution of life represents a major challenge for evolutionary biology. Guidance for finding answers has emerged from disparate fields, from phylogenetics to modelling and synthetic ...