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Listar por autor "Edwards III, George"
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18F-THK5351 PET imaging, neuropathology and clinical progression in a tau mouse model
Vegas-Gómez, Laura; Edwards III, George; Hasan, Omar; Gámez, Nazaret; Schulz, Jonathan; Soto, Claudio; Schulz, Paul; Moreno-González, Inés[et al.] (Alzheimer disease & Parkinson disease Conference 2021, 2021)Aims: Alzheimer’s disease (AD) and other associated dementias remain a consistent and unruly problem for the aging population and health. The neuropathology of AD is characterized by the extracellular deposition of ... -
Evaluation of neuroinflammation as modulator of tau aggregation in response to repetitive mild traumatic brain injury
López del Castillo, Inés; Edwards III, George; Vegas-Gómez, Laura; Moreno-González, Inés (CSHL, 2022)The pathological misfolding and aggregation of hyper-phosphorylated tau (ptau) protein in neurofibrillary tangles (NFTs) is the main hallmark of a group of neurodegenerative diseases called tauopathies. These include ... -
Longitudinal assessment of tau pet imaging and its correlation with neuropathology and clinical signs progression
Vegas-Gómez, Laura; Edwards III, George; Hasan, Omar; Gámez, Nazaret; Schulz, Jonathan; Soto, Claudio; Schulz, Paul; Moreno-González, Inés[et al.] (Cold Spring Harbor Laboratory, 2020-12-02)Alzheimer’s disease (AD) and other associated dementias remain a consistent and unruly problem for the aging population and health. As the world’s population increases, so does the prevalence of age-related dementias. The ... -
Molecular interaction between type 2 diabetes and Alzheimer's disease through cross-seeding of protein misfolding
Moreno-González, Inés; Edwards III, George; Salvadores, N.; Shahnawaz, Mohammad; Diaz-Espinoza, R.; Soto, C.[et al.] (Springer Nature, 2017)Numerous epidemiological studies have shown a significantly higher risk for development of Alzheimer's disease (AD) in patients affected by type 2 diabetes (T2D), but the molecular mechanism responsible for this association ...