Listar por autor "Salas, María"
Mostrando ítems 1-10 de 10
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Amoxicillin Haptenation of Alpha-Enolase is Modulated by Active Site Occupancy and Acetylation.
Vida-Pol, Yolanda
; Pérez-Inestrosa, Ezequiel; González Morena, Juan Manuel; Sanchez Gomez, Francisco J; Salas, María; Montañez-Vega, María Isabel; Altomare, Alessandra; Aldini, Giancarlo; Pajares, Maria Angeles; Pérez-Sala, Dolores[et al.] (Frontiers, 2022)
Allergic reactions to antibiotics are a major concern in the clinic. ß-lactam antibiotics are the class most frequently reported to cause hypersensitivity reactions. One of the mechanisms involved in this outcome is the ... -
Detection of Serum-Specific IgE by Fluoro-Enzyme Immunoassay for Diagnosing Type I Hypersensitivity Reactions to Penicillins
Ariza Veguillas, Adriana; Mayorga Mayorga, Cristobalina; Bogas Herrera, Gádor; Gaeta, Francesco; Salas, María; Valluzzi, Rocco Luigi; Labella, Marina; Pérez-Sánchez, Natalia Isabel; Caruso, Cristiano; Molina, Ana; Fernández-Duarte, Tahía Diana; Torres-Jaén, María Josefa; Romano, Antonino[et al.] (IOAP-MPDI, 2022-06-23)
Diagnosis of type I hypersensitivity reactions (IgE-mediated reactions) to penicillins is based on clinical history, skin tests (STs), and drug provocation tests (DPTs). Among in vitro complementary tests, the fluoro-enzyme ... -
Diagnosis of immediate reactions to amoxicillin: Comparison of basophil activation markers CD63 and CD203c in a prospective study
Céspedes Lagos, José Antonio; Fernández-Santamaría, Rubén; Ariza Veguillas, Adriana; Bogas Herrera, Gádor; Doña, Inmaculada; Rondón, Carmen; Salas, María; Labella, Marina; Frecha, Cecilia; Mayorga Mayorga, Cristobalina; Torres-Jaén, María Josefa; Fernández-Duarte, Tahía Diana[et al.] (Wiley, 2022-12-07)
Amoxicillin (AX) combined or not with clavulanic acid (CLV) is frequently involved in IgE-mediated reactions. Drug provocation test (DPT) is considered as the gold standard for diagnosis, although contraindicated in high-risk ... -
Direct Single-Dose Drug-Provocation Test Is Safe for Delabelling Penicillin Low-Risk Reactions in Adults
Labella, Marina; Rodriguez de Guzmán, Julia; Diez-Echave, Patricia; Salas, María; Fernández-Santamaría, Rubén; Mayorga, Cristobalina; Doña, Inmaculada; Torres-Jaén, María Josefa[et al.] (Wiley, 2025)
Background: Penicillins (PENs) are the most frequent drug-allergic reactions trigger. However, diagnostic work-up is complex and time-consuming: it requires skin testing (ST) and drug-provocation test (DPT), needing faster ... -
Genomic variants association with selective hypersensitivityreactions to amoxicillin and clavulanic acid
Nuñez, Rafael; Fernández-Santamaría, Rubén; Salas, María; Bogas, Gador; Diez-Echave, Patricia; Mayorga Mayorga, Cristobalina; Torres-Jaén, María Josefa; Fernández-Duarte, Tahía Diana[et al.] (Wiley, 2024-06-29)
In summary, there are rare variants found in our patients that could be related to the development of AX or CLV- induced IDHRs. Interestingly, some of these rare variants could be associated with selective response to ... -
LPS in combination with amoxicillin increases BAT sensitivity to amoxicillin IgE‐mediated hypersensitivity
Céspedes Lagos, José Antonio; Fernández-Santamaría, Rubén; Bogas Herrera, Gádor; Ariza Veguillas, Adriana; Doña, Inmaculada; Salas, María; Labella, Marina; Fernández-Duarte, Tahía Diana; Mayorga Mayorga, Cristobalina; Torres-Jaén, María Josefa; Frecha, Cecilia[et al.] (Wiley, 2024)
β-lactams (BLs), and among them, amoxicillin (AX) are the most current prescribed antibiotics to treat bacterial infections,1 and their use is related to an increasing prevalence of drug hypersensitivity reactions (DHRs),2 ... -
Medical algorithm: Diagnosis and treatment of nonsteroidal antiinflammatory drugs hypersensitivity
Doña, Inmaculada; Pérez-Sánchez, Natalia; Bogas, Gador; Moreno, Esther; Salas, María; Torres-Jaén, María Josefa[et al.] (Wiley, 2020)
Diagnosis in suspected hypersensitivity reactions to nonsteroidal anti-inflammatory drugs (NSAIDs) is complex as different mechanisms are involved: specific (selective responders, SRs) and nonspecific immunologically ... -
Resensitization in suspected penicillin allergy
Doña, Inmaculada; Guidolin, Lucia; Bogas Herrera, Gádor; Olivieri, Elisa; Labella, Marina; Schiapolli, Michele; Saenz de Santa María-García, Rocío; Dama, Annarita; Salas, María; Senna, Gianenrico; Bonadonna, Patrizia; Torres-Jaén, María Josefa[et al.] (Wiley, 2022-09-06)
The diagnosis of allergic reactions to penicillins (AR-PEN) is very complex as there is a loss of sensitization over time, which leads to negative skin tests (STs) and specific IgE in serum, and even to tolerance to the ... -
Synthetic antigenic determinants of clavulanic acid induce dendritic cell maturation and specific T cell proliferation in patients with immediate hypersensitivity reactions
Fernández-Santamaría, Rubén; Bogas Herrera, Gádor; Montañez-Vega, María Isabel; Ariza Veguillas, Adriana; Salas, María; Céspedes Lagos, José Antonio; Labella, Marina; Paris, Juan Luis; Pérez-Sánchez, Natalia Isabel; Pérez-de-Inestrosa-Villatoro, Ezequiel; Vida-Pol, Yolanda; Fernández-Duarte, Tahía Diana; Mayorga Mayorga, Cristobalina[et al.] (Wiley, 2022-05-24)
Background Immediate drug hypersensitivity reactions (IDHRs) to clavulanic acid (CLV) have increased in the last decades due to a higher consumption alongside amoxicillin (AX). Due to its chemical instability, diagnostic ... -
Usefulness of myeloid dendritic cells in cellular in vitro assays for evaluating immediate hypersensitivity reactions to betalactams.
Fernández-Santamaría, Rubén; Ariza Veguillas, Adriana; Bogas Herrera, Gádor; Salas, María; Calvo-Serrano, Silvia; Frecha, Cecilia; Mayorga Mayorga, Cristobalina; Torres-Jaén, María Josefa; Fernández-Duarte, Tahía Diana[et al.] (2023)
Introduction Dendritic cells (DCs) are the most potent antigen presenting cells (APCs) with an important role detecting, processing, and presenting antigens to T cells. The analysis of maturation after in vitro stimulation ...