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Listar por autor "Dorner, Marcus"
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Identification of Broad-Spectrum Antiviral Compounds by Targeting Viral Entry.
Mazzon, Michela; Ortega-Prieto, Ana María; Imrie, Douglas; Luft, Christin; Hess, Lena; Czieso, Stephanie; Grove, Joe; Skelton, Jessica Katy; Farleigh, Laura; Bugert, Joachim; Wright, Edward; Temperton, Nigel; Angell, Richard; Oxenford, Sally; Jacobs, Michael; Ketteler, Robin; Dorner, Marcus; Marsh, Mark[et al.] (MDPI, 2019)Viruses are a major threat to human health and economic well-being. In recent years Ebola, Zika, influenza, and chikungunya virus epidemics have raised awareness that infections can spread rapidly before vaccines or specific ... -
Kinetics of Early Innate Immune Activation during HIV-1 Infection of Humanized Mice.
Skelton, Jessica Katy; Ortega-Prieto, Ana María; Kaye, Steve; Jimenez-Guardeño, Jose Manuel; Turner, Jane; Malim, Michael H.; Towers, Greg J.; Dorner, Marcus[et al.] (ASM Journals, 2019-05-15)Human immunodeficiency virus type 1 (HIV-1) infection is associated with aberrant immune activation; however, most model systems for HIV-1 have been used during established infection. Here, we utilize ultrasensitive HIV-1 ... -
Phosphodiesterase-induced cAMP degradation restricts hepatitis B virus infection.
Evripioti, Antonia Alexandra; Ortega-Prieto, Ana María; Skelton, Jessica Katy; Bazot, Quentin; Dorner, Marcus (The Royal Society, 2019-04-08)Hepatitis B virus (HBV) entry into hepatocytes is mediated via a high-affinity interaction between the preS1 glycoprotein and sodium/bile acid cotransporting polypeptide (NTCP). To date, in vitro model systems rely on high ...