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Cross-Linking Mass Spectrometry Uncovers Interactions Between High-Density Lipoproteins and the SARS-CoV-2 Spike Glycoprotein.
Burnap, Sean A.; Ortega-Prieto, Ana María; Jimenez-Guardeño, Jose Manuel; Ali, Hashim; Takov, Kaloyan; Fish, Matthew; Shankar-Hari, Manu; Giacca, Mauro; Malim, Michael H.; Mayr, Manuel[et al.] (Elsevier, 2023)High-density lipoprotein (HDL) levels are reduced in patients with coronavirus disease 2019 (COVID-19), and the extent of this reduction is associated with poor clinical outcomes. While lipoproteins are known to play a key ... -
Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia
Braga, Luca; Ali, Hashim; Secco, Ilaria; Chiavacci, Elena; Neves, Guilherme; Goldhill, Daniel; Penn, Rebecca; Jimenez-Guardeño, Jose Manuel; Ortega-Prieto, Ana María; Bussani, Rossana; Cannata, Antonio; Rizzari, Giorgia; Collesi, Chiara; Scheider, Edoardo; Arosio, Daniele; Ajay M, Shah; Barclay, Wendy S; Malim, Michael H.; Burrone, Juan; Giacca, Mauro[et al.] (Springer Nature, 2021)COVID-19 is a disease with unique characteristics that include lung thrombosis1, frequent diarrhoea2, abnormal activation of the inflammatory response3 and rapid deterioration of lung function consistent with alveolar ...