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Extinction of hepatitis C virus by ribavirin in hepatoma cells involves lethal mutagenesis
Ortega-Prieto, Ana Maria; Sheldon, Julie; Grande-Pérez, Ana; Tejero, Hector; Gregori, Josep; Quer, Josep; Esteban, Juan I.; Domingo, Esteban; Perales, Celia[et al.] (PLOS One, 2013-08)
Lethal mutagenesis, or virus extinction produced by enhanced mutation rates, is under investigation as an antiviral strategy that aims at counteracting the adaptive capacity of viral quasispecies, and avoiding selection ...