Listar por autor "Alamilla Presuel, Juan Carlos"
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Acquisition resistance to bleomycin deregulates HSP77 and HSP60 proteins in response to stress
Burgos-Molina, Antonio Manuel
; Alamilla Presuel, Juan Carlos; Mercado-Sáenz, Silvia; González Vidal, Alejandro; Ruiz-Gómez, Miguel José (Aseica, 2022)
The HSP77 and HSP60 protein overexpression is implicated in bleomycin resistance. The resistant adquisition to antineoplastic drugs deregulate proteins involved in response to stress factors. -
Analysis of Immunotherapy in hepatocellular carcinoma
Burgos-Molina, Antonio Manuel; Alamilla Presuel, Juan Carlos; González Vidal, Alejandro; Ruiz-Gómez, Miguel José (Aseica, 2022)
One reason immunotherapy is important for Hepatocellular carcinoma, it’s because there are many immune cells in that organ. Because HCC is very aggressive, immunotherapy must be applied correctly. There are a lot of ... -
Analysis of Immunotherapy in Lung cancer
Burgos-Molina, Antonio Manuel; Alamilla Presuel, Juan Carlos; González Vidal, Alejandro; Ruiz-Gómez, Miguel José (Aseica, 2022)
There are many ways of immunotherapy for lung cancer, and that includes the use of drugs, molecular treatment, and even the combination with radiotherapy. But also, it’s important to investigate in the future the adverse ... -
Analysis of Immunotherapy in ovarian cancer
Burgos-Molina, Antonio Manuel; Alamilla Presuel, Juan Carlos; González Vidal, Alejandro; Ruiz-Gómez, Miguel José (Aseica, 2022)
There are many Immunotherapy methods in ovarian cancer. Even the immune cells themselves can be part of the immunotherapy. But also at molecular level, the immunotherapy can be applied, like maintaining damage in DNA or ... -
Analysis of Immunotherapy in Triple negative breast cancer
Burgos-Molina, Antonio Manuel; Alamilla Presuel, Juan Carlos; González Vidal, Alejandro; Ruiz-Gómez, Miguel José (Aseica, 2022)
TNBC cancer is complicated, most is about PD-L1 mechanism. Too many kinds of immunotherapy have been developed to treat TNCB. Nowadays, is complicated a fast and 100% accurate treatment for TNBC, because of cancer complications ... -
Beneficial interactions between the microbiota and the host increase immunity for a better response to treatment of cancer patients
Burgos-Molina, Antonio Manuel; González Vidal, Alejandro; Mercado-Sáenz, Silvia; Alamilla Presuel, Juan Carlos; Ruiz-Gómez, Miguel José (2022)
Numerous beneficial interactions between microbiota and host contribute to produce nutrients, metabolites, immunoglobulins and an increase in lymphocytes. The correct colonization of the intestine by microbiota induces a ... -
Cellular microenvironment can be modulated by factors influenced by microbiota to improve cancer treatment
Burgos-Molina, Antonio Manuel; González Vidal, Alejandro; Mercado-Sáenz, Silvia; Alamilla Presuel, Juan Carlos; Ruiz-Gómez, Miguel José (2022)
Numerous environmental factors affect the ecosystem of the microbiota, so its composition and diversity can be modified by changes produced in these factors. These alterations can facilitate the appearance of pathological ... -
Identificación de nuevas proteínas relacionadas con la resistencia a radiación ionizante y el envejecimiento celular en S. cerevisiae
(UMA Editorial, 2023-03-03)Introducción: La aparición de resistencia a radiación en células tumorales expuestas constituye un problema en el abordaje terapéutico de algunos tumores. La radiorresistencia es una preocupación grave, pues provoca un ... -
Metabolism is altered in the process of drug resistance acquisition
Burgos-Molina, Antonio Manuel; Alamilla Presuel, Juan Carlos; González Vidal, Alejandro; Ruiz-Gómez, Miguel José (Aseica, 2022)
Cells need energy to survive, therefore, they increase the different pathways available to obtain it. This suggests that the cell, due to the cytotoxicity of bleomycin, increases the routes to obtain energy. For this reason, ... -
Methods to study the intestinal microbiota to address the disease in a more precise and personalized way
Burgos-Molina, Antonio Manuel; González Vidal, Alejandro; Mercado-Sáenz, Silvia; Alamilla Presuel, Juan Carlos; Ruiz-Gómez, Miguel José (2022)
FISH, clone collection, DGGE, PCR and metagenomics techniques contribute to the study of the human microbiota in a precise and effective way, constituting very useful diagnostic tools in precision medicine to address patient ... -
Microbiota and body axes as a new therapeutic approach in precision medicine
Burgos-Molina, Antonio Manuel; González Vidal, Alejandro; Alamilla Presuel, Juan Carlos; Mercado-Sáenz, Silvia; Ruiz-Gómez, Miguel José (2022)
There is a marked relationship between the composition and diversity of the microbiota and various diseases distant from the intestine. This relationship occurs through different body axes between the intestine and the ... -
Molecular Mechanisms of Resistance to Ionizing Radiation in S. cerevisiae and Its Relationship with Aging, Oxidative Stress, and Antioxidant Activity.
González Vidal, Alejandro; Mercado-Sáenz, Silvia; Burgos-Molina, Antonio Manuel; Alamilla Presuel, Juan Carlos; Alcaraz, Miguel; Sendra-Portero, Francisco; Ruiz-Gómez, Miguel José[et al.] (MDPI, 2023-08-30)
The repair of the damage produced to the genome and proteome by the action of ionizing radiation, oxidizing agents, and during aging is important to maintain cellular homeostasis. Many of the metabolic pathways influence ... -
Proteins involved in carbon metabolism induce bleomycin resistance
Burgos-Molina, Antonio Manuel; Alamilla Presuel, Juan Carlos; Mercado-Sáenz, Silvia; González Vidal, Alejandro; Ruiz González, Óscar M.; Ruiz-Gómez, Miguel José[et al.] (Aseica, 2022)
S. cerevisiae acquires bleomycin resistance after a long-term exposure to this drug which causes overexpression of TPIS protein. It could be involved in the resistance process. For this reason, it could be good candidates ... -
Role of SODC protein in antineoplastic drug resistance
Alamilla Presuel, Juan Carlos; González Vidal, Alejandro; Ruiz González, Óscar M.; Burgos-Molina, Antonio Manuel; Ruiz-Gómez, Miguel José (Aseica, 2022)
Cells need homeostasis to survive, therefore, they use the different pathways available to obtain it. The SODC protein overexpression, which is implicated in this process, suggests that could be implicated in the process ... -
The absence of microbiota dysbiosis is essential to maintain a healthy immune system in cancer patients
Burgos-Molina, Antonio Manuel; González Vidal, Alejandro; Alamilla Presuel, Juan Carlos; Mercado-Sáenz, Silvia; Ruiz-Gómez, Miguel José (2022)
Gut microbiota is required for mucosal immunity. The intestinal mucosa is the main location for microbiome-host interactions. The dynamic interaction between microbiome and environmental factors modulate mucosal and systemic ... -
The relationship between SARS-Cov2 infection and microbiota is of special interest in cancer patients
Burgos-Molina, Antonio Manuel; González Vidal, Alejandro; Alamilla Presuel, Juan Carlos; Mercado-Sáenz, Silvia; Ruiz-Gómez, Miguel José (2022)
SARS-Cov2 can produce an imbalance in the diversity of microbiota leading to different symptoms and affecting the health and response of cancer patients to treatment. Therefore, it is important to further investigate in ...