Listar por autor "Sánchez-Ruiz, Antonio"
Mostrando ítems 1-6 de 6
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An array of bengamide E analogues modified at the terminal olefinic position: Synthesis and antimor properties.
Martín-Gálvez, Francisca; García-Ruiz, Cristina; Sánchez-Ruiz, Antonio; Valeriote, Frederick A.; Sarabia-García, Francisco Ramón
(Chemistry Europe · European Chemical Societies Publishing, 2013-03-19)
Based on our previously described synthetic strategy for bengamide E, a natural product of marine origin with antitumor activity, a small library of analogues modified at the terminal olefinic position was generated with ... -
Epi-, epoxy- and C2-modified bengamides: Synthesis and biological Evaluation
Sarabia-García, Francisco Ramón; Martín-Gálvez, Francisca; García-Ruiz, Cristina; Sánchez-Ruiz, Antonio; Vivar García, Carlos (ACS, 2013)
With the objective of investigating the influence of structural modifications of the polyketide chain of the bengamides upon their antitumoral activities, we targeted the preparation of bengamide E analogues with modification ... -
Exploring the reactivity of chiral glycidic amides for their applications in synthesis of bioactive compounds.
Sarabia-García, Francisco Ramón; Vivar García, Carlos; García-Ruiz, Cristina; Sánchez-Ruiz, Antonio; Pino-González, María Soledad; García-Castro, Miguel; Chammaa, Samy[et al.] (Wiley, 2014-05)
A new class of chiral sulfonium salts, derived from L- and D-methionine, has been designed and successfully employed in our laboratories for the diastereoselective synthesis of glycidic amides. The epoxy amides obtained ... -
Exploring the ring-closing metathesis for the construction of the solomonamide macrocyclic core: identification of bioactive precursors
Cheng-Sánchez, Iván; Sánchez-Ruiz, Antonio; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel; Carrillo Fernández, Paloma; Rodríguez-Quesada, Ana María; López-Romero, Juan Manuel; Sarabia-García, Francisco Ramón[et al.] (2018-10-19)
New synthetic strategies directed toward the novel cyclopeptides solomonamides have been explored utilizing an olefin metathesis as the key reaction. In the various strategies investigated, we worked on minimally oxidized ... -
Magnetic graphene molecularly imprinted polypyrrole polymer (MGO@MIPy) for electrochemical sensing of malondialdehyde in serum samples
Montoro-Leal, Pablo; Zougagh, Mohammed; Sánchez-Ruiz, Antonio; Rios, Angel; Vereda-Alonso, Elisa Isabel (Elsevier, 2022-03-12)
A modified screen-printed carbon electrode (SPCE) has been designed and fabricated for the determination of malondialdehyde (MDA), an important biomarker of oxidative stress. Magnetic graphene oxide (MGO) was synthesized ... -
The Development of the Bengamides as New Antibiotics against Drug-Resistant Bacteria
Porras Alcalá, Cristina; Moya-Utrera, Federico; García-Castro, Miguel; Sánchez-Ruiz, Antonio; López-Romero, Juan Manuel; Pino-González, María Soledad; Díaz-Morilla, Amelia; Kitamura, Seiya; W. Wolan, Dennis; Prados, Jose; Melguizo, Consolación; Cheng-Sánchez, Iván; Sarabia-García, Francisco Ramón[et al.] (IOAP-MPDI, 2022-05-31)
The bengamides comprise an interesting family of natural products isolated from sponges belonging to the prolific Jaspidae family. Their outstanding antitumor properties, coupled with their unique mechanism of action and ...