Listar por autor "Matas-Rico, Elisa"
Mostrando ítems 1-18 de 18
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Absence of LPA1 signaling results in defective cortical development
Estivill-Torrús, Guillermo; Llebrez Zayas, Pedro; Matas-Rico, Elisa; Rodríguez de Fonseca, Fernando; Chun, Jerold; Santín-Núñez, Luis Javier
; Pedraza-Benítez, María del Carmen; De-Diego-Barbado, Isabel; Del Arco-Herrera, Ignacio; Fernández-Llebrez, Pedro[et al.] (Oxford academy, 2008-04)
Lysophosphatidic acid (LPA) is a simple phospholipid with extracellular signaling properties mediated by specific G protein-coupled receptors. At least 2 LPA receptors, LPA(1) and LPA(2), are expressed in the developing ... -
Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8+ T cells
(2022)To improve the efficacy of immunotherapy, it is essential to better understand how cytotoxic CD8+ T cells infiltrate into tumors. Here, we examine a role for autotaxin (ATX) in this process. ATX (encoded by ENPP2) is a ... -
Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8+ T cells
(CELLPRESS, 2021)Autotaxin (ATX; ENPP2) produces lysophosphatidic acid (LPA) that regulates multiple biological functions via cognate G protein-coupled receptors LPAR1-6. ATX/LPA promotes tumor cell migration and metastasis via LPAR1 and ... -
Behavioral phenotype of maLPA1-null mice: increased anxiety-like behavior and spatial memory deficits
Santín-Núñez, Luis Javier; Bilbao, Ainhoa; Pedraza-Benítez, María del Carmen; Matas-Rico, Elisa; López-Barroso, Diana; Castilla-Ortega, María Estela; Sánchez-López, Jorge; Riquelme, Raquel; Varela Nieto, Isabel; de la Villa, P.; Surdiaz, Margarita; Chun, Jerold; Rodríguez de Fonseca, Fernando; Estivill-Torrús, Guillermo[et al.] (Wiley, 2009-11)
Lysophosphatidic acid (LPA) has emerged as a new regulatory molecule in the brain. Recently, some studies have shown a role for this molecule and its LPA1 receptor in the regulation of plasticity and neurogenesis in the ... -
Deletion of lysophosphatidic acid receptor LPA1 reduces neurogenesis in the mouse dentate gyrus
Matas-Rico, Elisa; Garcia Diaz, Beatriz; Llebrez Zayas, Pedro; López-Barroso, Diana; Santín-Núñez, Luis Javier; Pedraza-Benítez, María del Carmen; Smith-Fernández, José Aníbal; Téllez-Santana, Teresa; Redondo-Bautista, Maximino; Chun, Jerold; Rodriguez-de-Fonseca, Fernando; Estivill-Torrús, Guillermo[et al.] (Elsevier, 2008)
Neurogenesis persists in certain regions of the adult brain including the subgranular zone of the hippocampal dentate gyrus wherein its regulation is essential, particularly in relation to learning, stress and modulation ... -
Exploratory, anxiety and spatial memory impairments are dissociated in mice lacking the LPA1 receptor
Castilla-Ortega, María Estela; Sánchez-López, Jorge; Hoyo-Becerra, Carolina; Matas-Rico, Elisa; Zambrana-Infantes, Emma; Chun, Jerold; Rodríguez de Fonseca, Fernando; Pedraza-Benítez, María del Carmen; Estivill-Torrús, Guillermo; Santín-Núñez, Luis Javier[et al.] (Elsevier, 2010-07)
Lysophosphatidic acid (LPA) is a new, intercellular signalling molecule in the brain that has an important role in adult hippocampal plasticity. Mice lacking the LPA1 receptor exhibit motor, emotional and cognitive ... -
GABAergic deficits in absence of LPA1 receptor, associated anxiety-like and coping behaviors, and amelioration by interneuron precursor transplants into the dorsal hippocampus
Rosell-Valle, Cristina; Martínez-Losa, Magdalena; Matas-Rico, Elisa; Castilla-Ortega, María Estela; Zambrana-Infantes, Emma; Gómez-Conde, Ana Isabel; Sánchez-Salido, Lourdes; Ladrón de Guevara-Miranda, David; Pedraza-Benítez, María del Carmen; Serrano-Castro, Pedro Jesús; Chun, Jerold; Rodríguez de Fonseca, Fernando; Álvarez Dolado, Manuel; Santín-Núñez, Luis Javier; Estivill-Torrús, Guillermo[et al.] (Springer Link, 2021-04-01)
Defects in GABAergic function can cause anxiety- and depression-like behaviors among other neuropsychiatric disorders. Therapeutic strategies using the transplantation of GABAergic interneuron progenitors derived from the ... -
GDE2-RECK controls ADAM10 α-secretase-mediated cleavage of amyloid precursor protein
(American Association for the Advancement of Science, 2021-03)A disintegrin and metalloprotease 10 (ADAM10) is the α-secretase for amyloid precursor protein (APP). ADAM10 cleaves APP to generate neuroprotective soluble APPα (sAPPα), which precludes the generation of Aβ, a defining ... -
Glycerophosphodiesterase GDE2 Promotes Neuroblastoma Differentiation through Glypican Release and Is a Marker of Clinical Outcome
(Elsevier, 2016-10)Neuroblastoma is a pediatric embryonal malignancy characterized by impaired neuronal differentiation. A better understanding of neuroblastoma differentiation is essential for developing new therapeutic approaches. GDE2 ... -
Glycerophosphodiesterase GDE2/GDPD5 affects pancreas differentiation in zebrafish
(Elsevier, 2018-01)Notch signaling plays an essential role in the proliferation, differentiation and cell fate determination of various tissues, including the developing pancreas. One regulator of the Notch pathway is GDE2 (or GDPD5), a ... -
Loss of lysophosphatidic acid receptor LPA1 alters oligodendrocyte differentiation and myelination in the mouse cerebral cortex
Garcia Diaz, Beatriz; Riquelme, Raquel; Varela Nieto, Isabel; Jiménez-Lara, Antonio Jesús; De-Diego-Barbado, Isabel; Gómez-Conde, Ana Isabel; Matas-Rico, Elisa; Aguirre-Gómez, José Ángel; Chun, Jerold; Pedraza-Benítez, María del Carmen; Santín-Núñez, Luis Javier; Fernández Fernández, Óscar; Rodriguez-de-Fonseca, Fernando; Estivill-Torrús, Guillermo[et al.] (Springer Link, 2014)
Lysophosphatidic acid (LPA) is an intercellular signaling lipid that regulates multiple cellular functions, acting through specific G-protein coupled receptors (LPA1–6). Our previous studies using viable Malaga variant ... -
LPA is a chemorepellent for B16 melanoma cells: action through the cAMP-elevating LPA5 receptor
(PLOS One, 2011-12)Lysophosphatidic acid (LPA), a lipid mediator enriched in serum, stimulates cell migration, proliferation and other functions in many cell types. LPA acts on six known G protein-coupled receptors, termed LPA1–6, showing ... -
Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells
(Elife, 2017-08-29)The urokinase receptor (uPAR) is a glycosylphosphatidylinositol (GPI)-anchored protein that promotes tissue remodeling, tumor cell adhesion, migration and invasion. uPAR mediates degradation of the extracellular matrix ... -
New Perspectives on the Role of Liquid Biopsy in Bladder Cancer: Applicability to Precision Medicine.
Alberca-Del Arco, Fernardo; Prieto-Cuadra, Daniel; Santos-Perez de la Blanca, Rocio; Sáez-Barranquero, Felipe; Matas-Rico, Elisa; Herrera-Imbroda, Bernardo[et al.] (MDPI, 2024-02-16)
Bladder cancer (BC) is one of the most common tumors in the world. Cystoscopy and tissue biopsy are the standard methods in screening and early diagnosis of suspicious bladder lesions. However, they are invasive procedures ... -
Sequence-dependent trafficking and activity of GDE2, a GPI-specific phospholipase promoting neuronal differentiation.
(The Company of Biologist, 2020-02-10)GDE2 (also known as GDPD5) is a multispanning membrane phosphodiesterase with phospholipase D-like activity that cleaves select glycosylphosphatidylinositol (GPI)-anchored proteins and thereby promotes neuronal differentiation ... -
Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling
(Springer Nature, 2016-04)Autotaxin (ATX) generates the lipid mediator lysophosphatidic acid (LPA). ATX-LPA signalling is involved in multiple biological and pathophysiological processes, including vasculogenesis, fibrosis, cholestatic pruritus and ... -
Tumor immune escape by autotaxin: keeping eosinophils at bay
(Elsevier, 2024-04)Secreted autotaxin (ATX) promotes tumor progression by producing the pleiotropic lipid mediator lysophosphatidic acid (LPA). In a recent Nature Cancer paper, Bhattacharyya et al. show that ATX/LPA signaling ...