Listar por autor "Nualart, Francisco"
Mostrando ítems 1-11 de 11
-
Ascorbic acid and its transporter SVCT2, affect radial glia cells differentiation in postnatal stages
Saldivia, Natalia; Salazar, Katterine; Cifuentes-Rueda, Manuel
; Espinoza, Francisca; Harrison, Fiona E.; Nualart, Francisco[et al.] (Wiley, 2024-01-05)
Radial glia (RG) cells generate neurons and glial cells that make up the cerebral cortex. Both in rodents and humans, these stem cells remain for a specific time after birth, named late radial glia (lRG). The knowledge of ... -
Ascorbic acid and its transporter SVCT2, affect radial glia cells differentiation in postnatal stages
Saldivia, Natalia; Salazar, Katterine; Cifuentes-Rueda, Manuel; Espinoza, F; Harrison, FE; Nualart, Francisco[et al.] (Wiley, 2024-04)
Radial glia (RG) cells generate neurons and glial cells that make up the cerebral cortex. Both in rodents and humans, these stem cells remain for a specific time after birth, named late radial glia (lRG). The knowledge of ... -
Basal Sodium-Dependent Vitamin C Transporter 2 polarization in choroid plexus explant cells in normal or scorbutic conditions
Ulloa, Viviana; Saldivia, Natalia; Ferrada, Luciano; Salazar, Katherine; Martínez, Fernando; Silva-Álvarez, Carmen; Magdalena, Rocío; Oviedo, María José; Montecinos, Hernán; Torres-Vergara, Pablo; Cifuentes-Rueda, Manuel; Nualart, Francisco[et al.] (Springer Nature, 2019-10)
Vitamin C is incorporated into the cerebrospinal fluid (CSF) through choroid plexus cells. While the transfer of vitamin C from the blood to the brain has been studied functionally, the vitamin C transporter, SVCT2, has ... -
Brain Glucose-Sensing Mechanism and Energy Homeostasis.
López-Gambero, Antonio Jesús; Martínez, Fernando; Salazar, Katty; Cifuentes-Rueda, Manuel; Nualart, Francisco (Springer Nature, 2019)
The metabolic and energy state of the organism depends largely on the availability of substrates, such as glucose for ATP production, necessary for maintaining physiological functions. Deregulation in glucose levels leads ... -
Dehydroascorbic acid, the oxidized form of vitamin C, improves renal histology and function in old mice
Forman, Katherine; Martínez, Fernando; Cifuentes-Rueda, Manuel; Fernández, Marcos; Bertinar, Romina; Torres, Pablo; Salazar, Katherine; Godoy, Alejandro; Nualart, Francisco[et al.] (Wiley, 2020-12)
Oxidative stress and inflammation are crucial factors that increase with age. In the progression of multiple age-related diseases, antioxidants and bioactive compounds have been recognized as useful antiaging agents. ... -
Hyperglycemia increases SCO-spondin and Wnt5a secretion into the cerebrospinal fluid to regulate ependymal cell beating and glucose sensing
Nualart, Francisco; Cifuentes-Rueda, Manuel; Ramírez, Eder; Martínez, Fernando; Barahona, M José; Ferrada, Luciano; Saldivia, N; Borgonzone, Ernesto R; Thorens, B; Salazar, Katterine[et al.] (Public Library of Science, 2023-09)
Hyperglycemia increases glucose concentrations in the cerebrospinal fluid (CSF), activating glucose-sensing mechanisms and feeding behavior in the hypothalamus. Here, we discuss how hyperglycemia temporarily modifies ... -
IIIG9 inhibition in adult ependymal cells changes adherens junctions structure and induces cellular detachment.
Baeza, Víctor; Cifuentes-Rueda, Manuel; Martínez, Fernando; Ramírez, Eder; Nualart, Francisco; Ferrada, Luciano; Oviedo, María José; De Lima, Isabelle; Troncoso, Ninoschka; Saldivia, Natalia; Salazar, Katty[et al.] (Springer Nature, 2021)
Ependymal cells have multiple apical cilia that line the ventricular surfaces and the central canal of spinal cord. In cancer, the loss of ependymal cell polarity promotes the formation of different types of tumors, such ... -
Is IIIG9 a New Protein with Exclusive Ciliary Function? Analysis of Its Potential Role in Cancer and Other Pathologies
Oviedo, MJ; Ramírez, E; Cifuentes-Rueda, Manuel; Farkas, Carlos; Mella, Andy; Bertinat, Romina; Gajardo, Roberto; Ferrada, Luciano; Jara, Nery; De lima, Isabelle; Martínez, Fernando; Nualart, Francisco; Salazar, Katerine[et al.] (MDPI, 2022-10)
The identification of new proteins that regulate the function of one of the main cellular phosphatases, protein phosphatase 1 (PP1), is essential to find possible pharmacological targets to alter phosphatase function in ... -
The median eminence as the hypothalamic area involved in rapid transfer of glucose to the brain: functional and cellular mechanisms.
Martínez, Fernando; Cifuentes-Rueda, Manuel; Tapia, Juan Carlos; Nualart, Francisco (Springer Nature, 2019-08)
Our data proposes that glucose is transferred directly to the cerebrospinal fluid (CSF) of the hypothalamic ventricular cavity through a rapid "fast-track-type mechanism" that would efficiently stimulate the glucosensing ... -
Vitamin C Deficiency Reduces Neurogenesis and Proliferation in the SVZ and Lateral Ventricle Extensions of the Young Guinea Pig Brain
Jara, Nery; Cifuentes-Rueda, Manuel; Martínez, Fernando; González-Chavarría, Iván; Salazar, Katterine; Ferrada, Lucas; Nualart, Francisco[et al.] (IOAP-MPDI, 2022-10-14)
Although scurvy, the severe form of vitamin C deficiency, has been almost eradicated, the prevalence of subclinical vitamin C deficiency is much higher than previously estimated and its impact on human health might not be ... -
Vitamin C Deficiency Reduces Neurogenesis and Proliferation in the SVZ and Lateral Ventricle Extensions of the Young Guinea Pig Brain
Jara, Nery; Cifuentes-Rueda, Manuel; Martínez, Fernando; González-Chavarría, Ivan; Salazar, Katerine; Ferrada, Lucas; Nualart, Francisco[et al.] (MDPI, 2022-09)
Although scurvy, the severe form of vitamin C deficiency, has been almost eradicated, the prevalence of subclinical vitamin C deficiency is much higher than previously estimated and its impact on human health might not be ...