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Development of a Novel NGS Methodology for Ultrasensitive Circulating Tumor DNA Detection as a Tool for Early-Stage Breast Cancer Diagnosis
Jiménez-Rodríguez, Begoña; Alba-Bernal, Alfonso; López-López, Esperanza; Quirós-Ortega, María Elena; Carbajosa, Guillermo; Garrido-Aranda, Alicia; Álvarez-Pérez, Martína; Godoy-Ortiz, Ana; Queipo-Ortuño, María Isabel; Vicioso-Recio, Luis Prudencio; Díaz-Córdoba, Gema; Roldán-Díaz, María Dunia; Velasco-Suelto, Jesús; Hernando Melia, Cristina; Bermejo, Begoña; Julve-Parreño, Ana; Lluch, Ana; Pascual, Javier; Comino-Méndez, Iñaki; Alba-Conejo, Emilio[et al.] (IOAP-MDPI, 2022-12-21)Breast cancer (BC) is the most prevalent cancer in women. While usually detected when localized, invasive procedures are still required for diagnosis. Herein, we developed a novel ultrasensitive pipeline to detect circulating ... -
High IGKC-Expressing Intratumoral Plasma Cells Predict Response to Immune Checkpoint Blockade.
Onieva Zafra, Juan Luis; Xiao, Qingyang; Berciano-Guerrero, Miguel Ángel; Laborda-Illanes, Aurora; de Andrea, Carlos; Chaves, Patricia; Piñeiro Pereda, María del Pilar; Garrido-Aranda, Alicia; Gallego-Domínguez, Elena María; Sojo, Belén; Gálvez Carvajal, Laura; Chica Parrado, María del Rosario; Prieto Cuadra, Juan Daniel; Pérez-Ruiz, Elisabeth; Farngren, Angela; Lozano, María José; Álvarez-Pérez, Martína; Jiménez, Pedro; Sánchez-Muñoz, Alfonso; Oliver, Javier; Cobo Dols, Manuel Ángel; Alba-Conejo, Emilio; Barragán, Isabel[et al.] (MDPI, 2022)Resistance to Immune Checkpoint Blockade (ICB) constitutes the current limiting factor for the optimal implementation of this novel therapy, which otherwise demonstrates durable responses with acceptable toxicity scores. ... -
Posibles funciones de la familia génica de la glutamato descarboxilasa en Populus
Garrido-Aranda, Alicia (Servicio de Publicaciones y Divulgación Científica, 2015)Aunque hace más de 50 años que se describió que la glutamato descarboxilasa (GAD) lleva a cabo la descarboxilación del glutamato para producir GABA, y en animales ha sido muy estudiada debido al papel del GABA como ... -
Transcript profiling of wood transcriptional regulators, wood chemistry and phenotyping in poplar and eucalyptus genotypes growgin under drought, salinity and limiting nitrogen conditions
Molina-Rueda, Juan Jesús; Garrido-Aranda, Alicia; Sixto, Hortensia; Sánchez, Mario; Cañellas, Isabel; López, Gustavo; Simoes, Rita; Mounet, Fabien; Alia, Ricardo; Leple, Jean-Charles; Grima-Pettenati, Jacqueline; Rodrígues, José; Gallardo-Alba, Fernando; Cantón, Francisco R.[et al.] (2014-06-11)The possibilities for using lignocellulosic biomass produced from forest crops in order to obtain second generation biofuels is a key issue in the current context of climate change and the promotion of renewable energy ...