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Listar por autor "Alonso, Ana"
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Antiviral, Immunomodulatory and Antiproliferative Activities of Recombinant Soluble IFNAR2 without IFN-ß Mediation
Hurtado-Guerrero, Isaac; Hernáez, Bruno; Pinto-Medel, Maria Jesús; Calonge, Esther; Rodriguez-Bada, José L; Urbaneja, Patricia; Alonso, Ana; Mena-Vázquez, Natalia; Aliaga, Pablo; Issazadeh-Navikas, Shohreh; Pavía-Molina, José; Leyva-Fernández, Laura; Alcamí, José; Alcamí, Antonio; Fernández-Fernández, Óscar; Oliver-Martos, Begoña[et al.] (MDPI, 2020)Soluble receptors of cytokines are able to modify cytokine activities and therefore the immune system, and some have intrinsic biological activities without mediation from their cytokines. The soluble interferon beta (IFN-ß) ... -
Generación y caracterización de modelos murinos transgénicos para el análisis de glutaminasas cerebrales
Peñalver Alonso, Ana (UMA Editorial, 2016)El estudio de modelos murinos transgénicos deficientes para un determinado gen (knockout, KO) es una de las principales herramientas que permite elucidar la función génica. Con el objetivo de modificar secuencias endógenas, ... -
Glutaminase and MMP-9 Downregulation in Cortex and Hippocampus of LPA1 Receptor Null Mice Correlate with Altered Dendritic Spine Plasticity
Peñalver Alonso, Ana; Campos-Sandoval, José Ángel; Blanco-Calvo, Eduardo; Cardona Ramírez, Carolina; Castilla, Laura; Martín-Rufián, Mercedes; Estivill-Torrús, Guillermo; Sánchez-Varo, Raquel María; Alonso-Carrión, Francisco José; Pérez-Hernández, Mercedes; Colado, María Isabel; Gutiérrez-Pérez, Antonia; Rodriguez-de-Fonseca, Fernando; Márquez-Gómez, Javier[et al.] (Frontiers, 2017-09-05)Lysophosphatidic acid (LPA) is an extracellular lipid mediator that regulates nervous system development and functions acting through G protein-coupled receptors (GPCRs). Here we explore the crosstalk between LPA1 receptor ... -
Glutaminase isoforms expression switches microRNA levels and oxidative status in glioblastoma cells.
De los Santos-Jiménez, Juan; Campos-Sandoval, José Ángel; Márquez-Torres, Clara; Urbano-Polo, Nieves; Brøndegaard, David; Martín-Rufián, Mercedes; Lobo, Carolina; Peñalver Alonso, Ana; Gómez García, María del Carmen; Martín-Campos, Janet; Cardona Ramírez, Carolina; Castilla, Laura; Da-Costa-Souza, Felipe; Cheng, Tzuling; Segura-Checa, Juan Antonio; Alonso-Carrión, Francisco José; Curi, Rui; Colquhoun, Alison; DeBerardinis, Ralph J; Márquez-Gómez, Javier; Mates-Sánchez, José Manuel[et al.] (BMC, 2021-02-20)Glutaminase isoenzymes GLS and GLS2 play apparently opposing roles in cancer: GLS acts as an oncoprotein, while GLS2 (GAB isoform) has context specific tumour suppressive activity. Some microRNAs (miRNAs) have been implicated ... -
Interferon receptor expression in multiple sclerosis patients
Oliver-Martos, Begoña; Mayorga Mayorga, Cristobalina; Leyva-Fernández, Laura; León, Antonio; Luque, Gloria; C Lopez, Juan; Tamayo, Jose A; Pinto-Medel, Maria Jesús; De Ramón, Enrique; Blanco, Eva; Alonso, Ana; Fernández Fernández, Óscar[et al.] (Elsevier, 2006)To determine the gene expression of IFNAR1, IFNAR2 and MxA protein and the association with IFNbeta treatment response in MS patients. MS patients treated with IFNbeta had a significant decrease in IFNAR1 and IFNAR2 ... -
Lysophosphatidic Acid and Glutamatergic Transmission.
Roza, Carolina; Campos-Sandoval, José Ángel; Gómez García, María del Carmen; Peñalver Alonso, Ana; Márquez-Gómez, Javier (Frontiers, 2019-05-28)Signaling through bioactive lipids regulates nervous system development and functions. Lysophosphatidic acid (LPA), a membrane-derived lipid mediator particularly enriched in brain, is able to induce many responses in ... -
Soluble Receptor Isoform of IFN-Beta (sIFNAR2) in Multiple Sclerosis Patients and Their Association With the Clinical Response to IFN-Beta Treatment
Aliaga-Gaspar, Pablo; Hurtado-Guerrero, Isaac; Ciano-Petersen, Nicolas Lundahl; Urbaneja, Patricia; Brichette Mieg, Isabel; Virginia Reyes, Virginia; Rodriguez-Bada, Jose Luis; Alvarez-Lafuente, Roberto; Arroyo, Rafael; Quintana, Ester; Ramió-Torrentà, Lluis; Alonso, Ana; Leyva-Fernández, Laura; Fernández-Fernández, Óscar; Oliver-Martos, Begoña; arroyo, rafael[et al.] (2021-12)Protein and mRNA levels of sIFNAR2 increased after IFN-b treatment. According to the clinical response, only non-responders increased sIFNAR2 significantly at both protein and mRNA levels. sIFNAR2 gene expression correlated ... -
The efficacy of natalizumab in patients with multiple sclerosis according to level of disability: results of an observational study.
Fernández Fernández, Óscar; Papais Alvarenga, Marcos; Guerrero, Miguel; León, Antonio; Alonso, Ana; López-Madrona, Jose Carlos; Leyva-Fernández, Laura; Oliver-Martos, Begoña; De Ramón, Enrique; Luque, Gloria; Fernández, Victoria[et al.] (Sage Publications, 2010-11-18)Background: Little is known about how the level of disability at the start of treatment with natalizumab affects its efficacy. Objectives: The aim of this study was to investigate the effect of natalizumab on relapses in ...